Forums
Re: Medical Cannabis Treatments?
I have seen the oil get rid of moles I have on my leg. Four or five doses, then they just dissolve to nothing. So that is why I take it for myeloma.
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corrina69 - Name: corrina
- Who do you know with myeloma?: me
- When were you/they diagnosed?: october 2013
- Age at diagnosis: 51
Re: Medical Cannabis Treatments?
Truthseeker,
Can you tell me more about Oxis? I'm researching for a friend who was recently diagnosed with myeloma.
Thanks - glad to find this forum - very helpful.
Can you tell me more about Oxis? I'm researching for a friend who was recently diagnosed with myeloma.
Thanks - glad to find this forum - very helpful.
Re: Medical Cannabis Treatments?
Found this interesting study.
MV Barbado et al, "Cannabinoids As Antimyeloma Agents: a New Approach for the Treatment of Multiple Myeloma," ASH 2014 annual meeting abstract #4724 (link to original text)
Abstract:
Introduction:
Cannabinoids are the active components of Cannabis sativa. The interest in cannabinoid research has triggered only two decades ago following the discovery of the endocannabinoid system, mainly from the molecular characterization of endogenous receptors: CB1 (mostly expressed in the central nervous system) and CB2 (in immune cells). In the last few years, several groups have described their use as potential therapeutic agents in the treatment of pain, multiple sclerosis or Alzheimer. Moreover, increasing evidences have suggested their potential role as antitumor drugs.
Despite the abundant expression of CB2 in immune cells, very few studies have examined its use in hematological malignancies. Considering the high expression levels of CB2 in B-cells, we hypothesized that plasma cells (PCs) could also express high levels of CB2 and therefore might be an excellent target for cannabinoids.
Development:
Our objective was to evaluate the anti-tumor effect of cannabinoids in multiple myeloma and identify the mechanisms involved. We use the synthetic cannabinoids WIN-55 (CB1 and CB2 mixed agonist) and JWH-133 (CB2 selective agonist). We used multiple myeloma cell lines U266, MM1R, MM1S and RPMI8226 and primary PCs from patients and CD34+ cells from patients and healthy donors. Viability studies were carried out by MTT and cytometric analyses and the expression of receptors and the study of signaling pathways by Western blot (WB). Further, we tested the cannabinoid effects in vivo in murine models (NSG xenograft mice). We observed a high expression of CBs in CPs and a remarkable proapoptotic effect of cannabinoids on myelomatous cells. By contrast, the viability of the CD34 + hematopoietic progenitor cells remained unaffected irrespective of the dose used. In this regard, in multiple myeloma cells lines and primary cells from patients we observed cleavage of PARP as well as activation of caspases 8, 9, 3 and 2, the latter related to endoplasmic reticulum stress induced by the cannabinoids. This cannabinoid-induced apoptotic effect was also mediated by AKT and MAPKs signaling pathways, as assessed by WB. In addition, Fluorometric analyses confirmed that cannabinoids induce an early mitochondrial damage. Next we confirmed that cannabinoids increase the expression of SPT, the limiting enzyme for the synthesis of ceramides (membrane sphingolipids). The upregulation of SPT following cannabinoid incubation induced accumulation of ceramide, as assessed by immunohistochemistry. Furthermore, the incubation with myoricine, an SPT inhibitor, partially inhibited caspase 3 activation. Finally, we checked the antimyeloma effect of the cannabinoids in vivo, using a model of human multiple myeloma xenografted in immunodeficient mice NOD/SCID. Our results demonstrate a significant reduction in tumor growth, even tumor regression, as well as a significant increase of survival of cannabinoid-treated as compared to mice receiving vehicle.
Conclusion:
Cannabinoids have a very selective antitumor effect against multiple myeloma cells. This effect involves activation of apoptosis processes and alterations in the composition of membrane sphingolipids (ceramides). In vivo studies confirmed the efficacy of these agents in the treatment of multiple myeloma. This study lays the groundwork for the design of new anti-myeloma therapies.
MV Barbado et al, "Cannabinoids As Antimyeloma Agents: a New Approach for the Treatment of Multiple Myeloma," ASH 2014 annual meeting abstract #4724 (link to original text)
Abstract:
Introduction:
Cannabinoids are the active components of Cannabis sativa. The interest in cannabinoid research has triggered only two decades ago following the discovery of the endocannabinoid system, mainly from the molecular characterization of endogenous receptors: CB1 (mostly expressed in the central nervous system) and CB2 (in immune cells). In the last few years, several groups have described their use as potential therapeutic agents in the treatment of pain, multiple sclerosis or Alzheimer. Moreover, increasing evidences have suggested their potential role as antitumor drugs.
Despite the abundant expression of CB2 in immune cells, very few studies have examined its use in hematological malignancies. Considering the high expression levels of CB2 in B-cells, we hypothesized that plasma cells (PCs) could also express high levels of CB2 and therefore might be an excellent target for cannabinoids.
Development:
Our objective was to evaluate the anti-tumor effect of cannabinoids in multiple myeloma and identify the mechanisms involved. We use the synthetic cannabinoids WIN-55 (CB1 and CB2 mixed agonist) and JWH-133 (CB2 selective agonist). We used multiple myeloma cell lines U266, MM1R, MM1S and RPMI8226 and primary PCs from patients and CD34+ cells from patients and healthy donors. Viability studies were carried out by MTT and cytometric analyses and the expression of receptors and the study of signaling pathways by Western blot (WB). Further, we tested the cannabinoid effects in vivo in murine models (NSG xenograft mice). We observed a high expression of CBs in CPs and a remarkable proapoptotic effect of cannabinoids on myelomatous cells. By contrast, the viability of the CD34 + hematopoietic progenitor cells remained unaffected irrespective of the dose used. In this regard, in multiple myeloma cells lines and primary cells from patients we observed cleavage of PARP as well as activation of caspases 8, 9, 3 and 2, the latter related to endoplasmic reticulum stress induced by the cannabinoids. This cannabinoid-induced apoptotic effect was also mediated by AKT and MAPKs signaling pathways, as assessed by WB. In addition, Fluorometric analyses confirmed that cannabinoids induce an early mitochondrial damage. Next we confirmed that cannabinoids increase the expression of SPT, the limiting enzyme for the synthesis of ceramides (membrane sphingolipids). The upregulation of SPT following cannabinoid incubation induced accumulation of ceramide, as assessed by immunohistochemistry. Furthermore, the incubation with myoricine, an SPT inhibitor, partially inhibited caspase 3 activation. Finally, we checked the antimyeloma effect of the cannabinoids in vivo, using a model of human multiple myeloma xenografted in immunodeficient mice NOD/SCID. Our results demonstrate a significant reduction in tumor growth, even tumor regression, as well as a significant increase of survival of cannabinoid-treated as compared to mice receiving vehicle.
Conclusion:
Cannabinoids have a very selective antitumor effect against multiple myeloma cells. This effect involves activation of apoptosis processes and alterations in the composition of membrane sphingolipids (ceramides). In vivo studies confirmed the efficacy of these agents in the treatment of multiple myeloma. This study lays the groundwork for the design of new anti-myeloma therapies.
Re: Medical Cannabis Treatments?
I first knew that I would have a problem with myeloma in 1991. I was 35 and the advice I was given was to live a healthy progressive life until I would fall down. I managed a very active life until the end of 2008. In 2009, I was treated for multiple myeloma to remission and the completion of stem cell transfer.
I cannot say that in 2010 I was unwell, but I was not strong enough to contemplate much activity or travel until 2011. Throughout 2011 and 20112 I was under maintenance treatments for multiple myeloma but in full remission until late 2012. For 2013, I was given Revlimid for the first time. The treatment cocktail at the beginning of 2013 delivered rather nasty nausea, similar to the first cycles of chemotherapy I had taken. In addition, there were blood clots, gout, steroid-induced diabetes, along with general discomforts with digestion.
All this was corrected and in 2014 I completed chemo to being in remission but was unable to gain enough stem cell recovery to afford a transplant. Essentially, this was the end of the line for treatments under our NHS in the UK.
My life has been very international and upon long occasions in East Africa. My business partner last year began to make cannabis resin "cold" extract for me to eat. My partner is a civil engineer and we have unlimited access to completely organic wild seed Sativa variety. I began eating about one gram a day at the beginning of February this year. My first oncology report was not impressive and there is indication that the myeloma is returning.
However; I can say without any ambiguity, I have no clue if the resin is a cure for any form of cancer, while I am aware of extensive research, I have linked our supply to some research at the local university that is investigating Crohn's disease and multiple sclerosis along with gut, bowl, and other cancers, with particular emphasis on breast cancer.
On an exceptionally positive note, following a couple of days of fuzziness, the direct impact is an overall feeling of wellness. If you're a long term multiple myeloma sufferer or anyone who has suffered peripheral nerve damage from the chemotherapy I would recommend the taking of cannabis resin as a food supplement. In addition to an improved feeling of wellness, I am reasonably fit at 58, but curtailed by all the myeloma impacts, I have been taking more exercise, I hardly need to take any insulin, I have not taken any acyclovir to fend of shingles, this winter to spring (I do try to not have much exposure to public places, but I am not a hermit) I have not caught any colds or flu, real energy sapping cold weather impacts avoided. I would point to the cannabis resin as the culprit for many good health and wellness impacts.
I have continued the dose each day and I am hoping that the oncologist blood analysis in early June will show improvements. However, I have already decided that I will not engage with chemotherapy again. I would like to pass from this world feeling well.
If able, I certainly recommend learning to produce your own resin according o the simple Rick Simpson recipes on the internet. Our understanding is that patience and sticking exactly to the temperatures and methods illustrated syncs with the scientific studies that suggest strongly that one gains the most active benefit for triggering the cannabinoid system by eating and digesting cold temp prepared resin. That is resin that is a natural ration of unadulterated cannabinoids, in particular not changed by heat. Smoking may be fine for a hit, but it's no the same as eating consistently. The overall feeling of wellbeing cannot be denied.
I cannot say that in 2010 I was unwell, but I was not strong enough to contemplate much activity or travel until 2011. Throughout 2011 and 20112 I was under maintenance treatments for multiple myeloma but in full remission until late 2012. For 2013, I was given Revlimid for the first time. The treatment cocktail at the beginning of 2013 delivered rather nasty nausea, similar to the first cycles of chemotherapy I had taken. In addition, there were blood clots, gout, steroid-induced diabetes, along with general discomforts with digestion.
All this was corrected and in 2014 I completed chemo to being in remission but was unable to gain enough stem cell recovery to afford a transplant. Essentially, this was the end of the line for treatments under our NHS in the UK.
My life has been very international and upon long occasions in East Africa. My business partner last year began to make cannabis resin "cold" extract for me to eat. My partner is a civil engineer and we have unlimited access to completely organic wild seed Sativa variety. I began eating about one gram a day at the beginning of February this year. My first oncology report was not impressive and there is indication that the myeloma is returning.
However; I can say without any ambiguity, I have no clue if the resin is a cure for any form of cancer, while I am aware of extensive research, I have linked our supply to some research at the local university that is investigating Crohn's disease and multiple sclerosis along with gut, bowl, and other cancers, with particular emphasis on breast cancer.
On an exceptionally positive note, following a couple of days of fuzziness, the direct impact is an overall feeling of wellness. If you're a long term multiple myeloma sufferer or anyone who has suffered peripheral nerve damage from the chemotherapy I would recommend the taking of cannabis resin as a food supplement. In addition to an improved feeling of wellness, I am reasonably fit at 58, but curtailed by all the myeloma impacts, I have been taking more exercise, I hardly need to take any insulin, I have not taken any acyclovir to fend of shingles, this winter to spring (I do try to not have much exposure to public places, but I am not a hermit) I have not caught any colds or flu, real energy sapping cold weather impacts avoided. I would point to the cannabis resin as the culprit for many good health and wellness impacts.
I have continued the dose each day and I am hoping that the oncologist blood analysis in early June will show improvements. However, I have already decided that I will not engage with chemotherapy again. I would like to pass from this world feeling well.
If able, I certainly recommend learning to produce your own resin according o the simple Rick Simpson recipes on the internet. Our understanding is that patience and sticking exactly to the temperatures and methods illustrated syncs with the scientific studies that suggest strongly that one gains the most active benefit for triggering the cannabinoid system by eating and digesting cold temp prepared resin. That is resin that is a natural ration of unadulterated cannabinoids, in particular not changed by heat. Smoking may be fine for a hit, but it's no the same as eating consistently. The overall feeling of wellbeing cannot be denied.
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ckwr
Re: Medical Cannabis Treatments?
Yet another scientific study confirms THC/CBD effectively and safely kills multiple myeloma cells..
"The OWC multiple myeloma study was done by three repetitive tests on the effect of cannabis extract with various combination ratios of THC/CBD and pure THC and CBD (50% concentration). The results present more than 60% malignant cell death. More results of pure THC and CBD are under further analysis.
Multiple myeloma cells were cultured for 48 hours with CBD and THC (all cannabis extracts) as compare to their combinations - CBD: THC 1:1; CBD: THC 5:1 and CBD: THC 1:5. Combination Index (CI) value <1, =1, >1 indicates synergism, additive effect, and antagonism, respectively. Each treatment was performed in triplicate in four independent experiments and presented as mean. The treatment of CBD in combination with THC had synergistic effect, being their cytotoxic effect is higher with each of the three combinations tested.
CBD and THC decreased survival of multiple myeloma cells in a concentration-dependent manner."
Full story here:
http://www.prnewswire.com/news-releases/owc-pharmaceutical-research-announces-the-promising-results-of-phase-lab-testing-for-multiple-myeloma-507849711.html
"The OWC multiple myeloma study was done by three repetitive tests on the effect of cannabis extract with various combination ratios of THC/CBD and pure THC and CBD (50% concentration). The results present more than 60% malignant cell death. More results of pure THC and CBD are under further analysis.
Multiple myeloma cells were cultured for 48 hours with CBD and THC (all cannabis extracts) as compare to their combinations - CBD: THC 1:1; CBD: THC 5:1 and CBD: THC 1:5. Combination Index (CI) value <1, =1, >1 indicates synergism, additive effect, and antagonism, respectively. Each treatment was performed in triplicate in four independent experiments and presented as mean. The treatment of CBD in combination with THC had synergistic effect, being their cytotoxic effect is higher with each of the three combinations tested.
CBD and THC decreased survival of multiple myeloma cells in a concentration-dependent manner."
Full story here:
http://www.prnewswire.com/news-releases/owc-pharmaceutical-research-announces-the-promising-results-of-phase-lab-testing-for-multiple-myeloma-507849711.html
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Truthseeker
Re: Medical Cannabis Treatments?
Interesting. In any of the studies, do they estimate the equivalent amounts needed to kill myeloma cells in the body?
And not being one to understand the details of these studies, wouldn't gasoline also kill these myeloma cells?
And not being one to understand the details of these studies, wouldn't gasoline also kill these myeloma cells?
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Stann - Name: Stann
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: 9/11/09
- Age at diagnosis: 46
Re: Medical Cannabis Treatments?
I use a vaporizer for oil. I take a hit occasionally. It relaxes me and takes my mind off my myeloma and chemo. Was honest with my oncologist and told her. She said it was better than the leaf. She neither condoned it nor objected to it.
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coop223 - Name: derek cooper
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: November 2011
- Age at diagnosis: 57
Re: Medical Cannabis Treatments?
Stann wrote:
Gasoline may kill meyloma cells, but not safely. Cannabinoids exist naturally in all mamals, very effectively target cancer cells, and do no harm to normal cells.
As for dosing, anecdotally, the RSO (Rick Simpson Oil) community recommends 1 gram of oil, sublingual a day, for 60 days. From 1 pound of dry plant (455 grams, or about $3000 street value), will yield 55-60 grams of concentrated cannabinoid oil.
1 gram a day will get some high as a kite, others hardly feel any high. It depends on a lot of things, but generally all build up a tolerance rather quickly.
Interesting. In any of the studies, do they estimate the equivalent amounts needed to kill myeloma cells in the body?
And not being one to understand the details of these studies, wouldn't gasoline also kill these myeloma cells?
Gasoline may kill meyloma cells, but not safely. Cannabinoids exist naturally in all mamals, very effectively target cancer cells, and do no harm to normal cells.
As for dosing, anecdotally, the RSO (Rick Simpson Oil) community recommends 1 gram of oil, sublingual a day, for 60 days. From 1 pound of dry plant (455 grams, or about $3000 street value), will yield 55-60 grams of concentrated cannabinoid oil.
1 gram a day will get some high as a kite, others hardly feel any high. It depends on a lot of things, but generally all build up a tolerance rather quickly.
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truthseeker
Re: Medical Cannabis Treatments?
What about using THC or CBD edibles?
I can get edibles that come in the following concentrations: 5 mg THC and 10 mg CBD (they are 2 separate products). What would be an appropriate dose and frequency to take these for a multiple myeloma patient?
Thanks in advance --
I can get edibles that come in the following concentrations: 5 mg THC and 10 mg CBD (they are 2 separate products). What would be an appropriate dose and frequency to take these for a multiple myeloma patient?
Thanks in advance --
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AEB
Re: Medical Cannabis Treatments?
Hi,
I'm taking cannabis oil and eat a hand full of cannabis leafs a day. Also take 8 gm of curcumin as well as Velcade and dex once a week. I have only got minor side effects so far, been on treatment for almost three months. My paraprotein was 54 g/L (5.4 g/dL) when I started treatment, now down to 16. My haemoglobin went up first week, it's now in normal range. In fact, most bloods are now normal.
So not sure if the cannabis with Velcade and curcumin have worked better together or I may have responded well just on the Velcade anyway,
We will have to wait and see if the number stay down
Cheers Corrina
I'm taking cannabis oil and eat a hand full of cannabis leafs a day. Also take 8 gm of curcumin as well as Velcade and dex once a week. I have only got minor side effects so far, been on treatment for almost three months. My paraprotein was 54 g/L (5.4 g/dL) when I started treatment, now down to 16. My haemoglobin went up first week, it's now in normal range. In fact, most bloods are now normal.
So not sure if the cannabis with Velcade and curcumin have worked better together or I may have responded well just on the Velcade anyway,
We will have to wait and see if the number stay down
Cheers Corrina
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corrina01 - Name: corrina
- Who do you know with myeloma?: me
- When were you/they diagnosed?: October 2013
- Age at diagnosis: 51
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