I have a family member with multiple myeloma. I have been actively researching cannabinoids and hemp oil for about 5 months. There is a ton of research out there on it effective use as an anti cancer medicine, and many testimonials claiming full cures. I have not found any information or testimonials regarding its effectiveness specifically on multiple myeloma, though there is a lot buzz out there regarding its effective use against leukemia.
The first thing to realize is cannabinoids are the real deal. it is not a scam designed by a bunch of pot heads, though the federal government and Big Pharma hope you continue to think so.. The federal government has known cannabinoids cured cancer since 1974 when it funded program at university of Virginia to prove pot had a negative effect on the immune system.Their final report showed pot had no negative effect on immune system and killed cancer cells in a petri dish and in mice. our wonderful federal government immediately defunded the program...and now now hold a patent on cannabinoids.
if you want to read peer reviewed medical science on cannabinoids, just go to "pub med" online and do a search on cancer and cannabinoids. Our scientist and doctors are WAY behind the hemp movement on cannabinoids, but are starting to catch up. research is greatly hampered by the federal government who still lists pot as a schedule 1 drug worse than coke and meth with "no known medicalnL value" even though there is 6000 years of history of it medicinal use.... plus we are brainwashed to not believe pot can cure cancer . I did tons of research.no one to this date, has proven that cannabinoids don't cure cancer. Big Pharma won't even try, because they know they do. Your doctors training is greatly influenced by big pharma. ask you doctor if they know about the endocannabinoid system. if they do not, you should find one that does.
I made the hemp oil for my family member. she will not take it. I can not make her, but i work daily to undue her government/big pharma/and oncologist brainwashing. I put the oil in her fridge in hopes she will take it before the chemo and cancer take her. In the meantime, I am treating a cancer stricken dog with the oil and will continue to research and hope to eventually find a patient in the rather small multiple myeloma community who is also in the rather small (but rapidly growing) group of people treating their cancer with hemp oil. Oddly, my family member is to chicken to go first at treating her multiple myeloma with non toxic cannabinoids, but gladly takes toxic chemo poison in trials run by big pharma with 5 pages of harmful side affects. My wife and I are not sick, but both took the oil for two months without any problems just to see any side effects...I got a litle high 3 times out of about 70 doses of oil, and only when I took too much). Hemp oil has already cured thousands of cancer...I just pray it works for multiple myeloma....And I pray we find that out soon.
Forums
Re: Medical Cannabis Treatments?
before my diagnosis I had irregular blood counts, electrolyte imbalances, and just didn't feel well. At the time I was going doctor to doctor but wasn't getting anywhere. I accidently ingested a family members weed oil, which was mixed with juice. (I drank it not knowing it was spiked!) I started having a lot of unpleasant symptoms, weakness, dizziness, trouble breathing, which lead to an irregular heart beat, shaking. After an ambulance ride to the hospital they admitted me overnight because my potassium had dropped to 2.4 so I needed to be hooked up to an IV to get potasium and fluids. they were worried I was going to have heart attack. Not sure what happened, but it was not fun. I will likely never touch weed again! It may seem safe, but myeloma can cause alot of other issues and as someone mentioned weed has never been tested in a clinical trials with multiple myeloma patients so buyer beware!
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Anonymous
Re: Medical Cannabis Treatments?
From what I can tell, no one has any real idea of whether cannabis would help or hinder treatment for myeloma. Pub Med has virtually nothing on the subject. The closest I could get involved some work that's been done on cannabis and a couple of kinds of leukemia in which there's some (very) preliminary evidence that cannabinoids may help to make cancer cells more susceptible to anti-cancer drugs. That's not much to go on. It therefore seems to me that if someone wants to use marijuana to relieve stress, increase appetite, or help with sleep problems then they ought to do so. (That's bearing in mind that you probably shouldn't smoke anything if you're immune system is heavily compromised.) Taking it with the idea that it will cure the disease is not something backed by the scientific evidence right now.
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Mike F - Name: Mike F
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: May 18, 2012
- Age at diagnosis: 53
Re: Medical Cannabis Treatments?
Mike F. wrote:
> From what I can tell, no one has any real idea of whether cannabis would
> help or hinder treatment for myeloma. Pub Med has virtually nothing on the
> subject. The closest I could get involved some work that's been done on
> cannabis and a couple of kinds of leukemia in which there's some (very)
> preliminary evidence that cannabinoids may help to make cancer cells more
> susceptible to anti-cancer drugs. That's not much to go on. It therefore
> seems to me that if someone wants to use marijuana to relieve stress,
> increase appetite, or help with sleep problems then they ought to do so.
> (That's bearing in mind that you probably shouldn't smoke anything if
> you're immune system is heavily compromised.) Taking it with the idea that
> it will cure the disease is not something backed by the scientific evidence
> right now.
I agree. If it helps with relieving stress, and side effects of chemo, I'm all for it.
> From what I can tell, no one has any real idea of whether cannabis would
> help or hinder treatment for myeloma. Pub Med has virtually nothing on the
> subject. The closest I could get involved some work that's been done on
> cannabis and a couple of kinds of leukemia in which there's some (very)
> preliminary evidence that cannabinoids may help to make cancer cells more
> susceptible to anti-cancer drugs. That's not much to go on. It therefore
> seems to me that if someone wants to use marijuana to relieve stress,
> increase appetite, or help with sleep problems then they ought to do so.
> (That's bearing in mind that you probably shouldn't smoke anything if
> you're immune system is heavily compromised.) Taking it with the idea that
> it will cure the disease is not something backed by the scientific evidence
> right now.
I agree. If it helps with relieving stress, and side effects of chemo, I'm all for it.
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Stan W. - Name: Stan
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: SMM-April 2012
- Age at diagnosis: 58
Re: Medical Cannabis Treatments?
Some pretty impressive people at the University of Pittsburg's Drug Discovery Institute believe that cannabinoids may be effective in treating multiple myeloma. (see excerpt and link at bottom of post)
Consider the Drug Discovery Institutes interest in cannabinoids and meyloma, along with the 929 peer reviewed documents on pub med regarding cannabinoids and cancer http://www.ncbi.nlm.nih.gov/pubmed?term=cannabinoid%20cancer
and the success the Dr. Melamede out of Cannabis Science in Colorado curing skin cancer with cannabinoids
http://www.4-traders.com/CANNABIS-SCIENCE-INC-5293768/news/Cannabis-Science-Inc-FDA-Fast-Tracks-New-Cancer-Drug-for-Skin-Cancer-While-Cannabis-Science-Offe-13998861/
and the plethora of testimonials on the WWW from people who have cured their cancer with hemp oil...
http://www.youtube.com/watch?v=uM51FBFZ9oU
http://cannabisnationradio.com/dennis-hill
and the 800+ pages of reference material supporting cannabinoid treatment in a host of cancers and other conditions gathered by Hemp Activist Granny Storm Crow
http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&ved=0CD0QFjAC&url=http%3A%2F%2Fwww.letfreedomgrow.com%2Fcmu%2FGrannysListJan2012.pdf&ei=ejDmUN2KM8KB0AGk2oGYCw&usg=AFQjCNG3Mxay0nOPaIIWBbmdleG-d4a9og&bvm=bv.1355534169,d.dmQ
and the wonderfully written "The Cannabis Papers, a citizen's guide to cannabinoids"
http://thecannabispapers.weebly.com/
ITS SURE IS GETTING INCREASINGLY DIFFICULT TO DENY THAT CANNABINOIDS ARE EFFECTIVE IN TREATING MANY AILMENTS, INCLUDING MANY CANCERS.
I pray we find out real soon that its effective against multiple meyloma.
The following was extracted from University of Pittsburg's Drug Discovery institute regarding their study of cannabinoids efficacy in treating multiple meyloma.
http://www.upddi.pitt.edu/index.php?page=discoveries-and-opportunities
CB2 Chemical Agents for Multiple Meyloma (multiple myeloma) Intervention
Project collaborators: Xiang-Qun (Sean) Xie (PI, Dept. Pharmaceutical Sciences), D. Roodman (UPMC), Julie Roodman (UPMC), and Jurg Gertsch (University of Bern, Switzerland).
Innovation. We have for the first time discovered that CB2 receptor is highly expressed in (multiple myeloma) cell lines, and also first to discover novel CB2 ligands with therapeutic potential for multiple myeloma treatment (see patents 1,2). A series of selective CB2 inverse agonists with novel chemical scaffolds were synthesized and top 3 compounds showed excellent CB2 binding affinity (< 100 nM) and effective anti-MM activity. All these compounds exhibit good drug-like properties with no or minor toxicity to normal cells.
Significance and current market. Multiple myeloma (multiple myeloma) remains an incurable malignancy with systematic morbidity and a median survival of 3-5 years. It accounts for 10% of all hematological malignancies, characterized by aberrant proliferation of terminally differentiated plasma cells and impairment in apoptosis capacity. Due to the interactions between myeloma cells and cells of the bone marrow microenvironment, the osteolytic bone disease associated with myeloma is inextricably linked with tumor progression. High incidence of bone metastasis in multiple myeloma patients (95-100%) is associated with severe bone pain and pathological fracture (60%), which has been defined as the result of activated osteoclast and suppressed osteoblast. While a diverse spectrum of novel agents has shown therapeutic potential in myeloma clinic, including bortezomib, lenalidomide and arsenic trioxide, however high relapse rates and drug resistance continue to plague these therapies due to blurred multiple myeloma pathogenesis. Thus, novel targets and treatment in multiple myeloma pathogenesis are of critical importance to improve the patient outcomes.
Expertise and know-how. We have identified the new multiple myeloma drug target and also discovered novel drug leads by our established expertise and how-how technologies. Our innovation was based on our recent discovery and the therapeutic hypothesis that cannabinoid receptor-2 (CB2) pathway plays important role in multiple myeloma cell growth and related bone disorder (see patent below). Distinct from cannabinoid receptor-1 (CB1) that expresses in brain neuron system, CB2 has been identified to be expressed exclusively in the immune system, especially on plasma B cells. However, the significance of CB2 signaling pathway in multiple myeloma, or the cancer of plasma B cells, had never been explored as a potential therapeutic target. With many years of research investigations and how-know technologies, we have found that high levels of expression of active CB2 was observed in human multiple myeloma cell lines and primary CD138+ myeloma cells. Our discovered CB2 ligand, phenylacetylamide (PAM, or XIE95), inhibits multiple myeloma growth through cell cycle modulation, mitotic death and cytoskeleton disruption. In particular, our studies show that CB2 gene silencing rescues PAM-induced inhibition of multiple myeloma cell proliferation. In summary, our data demonstrated that targeting CB2 pathway may represent a novel promising strategy for multiple myeloma treatment. Furthermore, it’s been reported that CB2 is expressed in osteoclast and osteoblast as well as their precursor cells. CB2-/- mice showed accelerated age-related trabecular bone loss and cortical expansion. CB2-/- osteoclast number and trabecular osteoblast activity were increased. The role of CB2 pathway in MM-induced bone remodeling, however, is poorly defined. We found that our compound PAM favorably suppressed osteoclast formation in both murine and human osteoclastogenesis. Overall, with our discovery of the abundance of CB2 in multiple myeloma cells and its regulation on immune cell function (e.g. pre-B cell retention, antibody production, etc.), the role of CB2 gene regulation in multiple myeloma pathogenesis and its promising therapeutic target in treatment have tempted us to investigate CB2 and multiple myeloma. Currently, the top hit compounds are under way for animal efficacy and toxicity studies. We are open for collaborations with academics and pharma industries
References:
Xie, X-Q., Feng, RT, and Peng Yang “Novel CB2 Inverse Agonists and Therapeutic Potential for Multiple Myeloma and Osteoporosis Bone Diseases”. (2012) Patent USSN: 61/576,041
Xie, X-Q*., J.Z. Chen and Y.X. Zhang. “Ligands Specific for Cannabinoid Receptor Subtype 2” (2009), WO 2009058377, 2008-US12395, 2007USSN 60/984,461.
Zhang YX, Xie, ZJ, Wang, LR, Lazo, JS, Gertsch, J, Schribeit B, Xie X-Q*: Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor. International Immunopharmacology. 2011;11:1303-10.
Chen, J.; Wang, J.; and Xie, X.-Q.* “GPCR structure-based virtual screening approach for CB2 antagonist search.” J. Chemical Information and Modeling. 2007;47:1626-1637. (100%)
Consider the Drug Discovery Institutes interest in cannabinoids and meyloma, along with the 929 peer reviewed documents on pub med regarding cannabinoids and cancer http://www.ncbi.nlm.nih.gov/pubmed?term=cannabinoid%20cancer
and the success the Dr. Melamede out of Cannabis Science in Colorado curing skin cancer with cannabinoids
http://www.4-traders.com/CANNABIS-SCIENCE-INC-5293768/news/Cannabis-Science-Inc-FDA-Fast-Tracks-New-Cancer-Drug-for-Skin-Cancer-While-Cannabis-Science-Offe-13998861/
and the plethora of testimonials on the WWW from people who have cured their cancer with hemp oil...
http://www.youtube.com/watch?v=uM51FBFZ9oU
http://cannabisnationradio.com/dennis-hill
and the 800+ pages of reference material supporting cannabinoid treatment in a host of cancers and other conditions gathered by Hemp Activist Granny Storm Crow
http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&ved=0CD0QFjAC&url=http%3A%2F%2Fwww.letfreedomgrow.com%2Fcmu%2FGrannysListJan2012.pdf&ei=ejDmUN2KM8KB0AGk2oGYCw&usg=AFQjCNG3Mxay0nOPaIIWBbmdleG-d4a9og&bvm=bv.1355534169,d.dmQ
and the wonderfully written "The Cannabis Papers, a citizen's guide to cannabinoids"
http://thecannabispapers.weebly.com/
ITS SURE IS GETTING INCREASINGLY DIFFICULT TO DENY THAT CANNABINOIDS ARE EFFECTIVE IN TREATING MANY AILMENTS, INCLUDING MANY CANCERS.
I pray we find out real soon that its effective against multiple meyloma.
The following was extracted from University of Pittsburg's Drug Discovery institute regarding their study of cannabinoids efficacy in treating multiple meyloma.
http://www.upddi.pitt.edu/index.php?page=discoveries-and-opportunities
CB2 Chemical Agents for Multiple Meyloma (multiple myeloma) Intervention
Project collaborators: Xiang-Qun (Sean) Xie (PI, Dept. Pharmaceutical Sciences), D. Roodman (UPMC), Julie Roodman (UPMC), and Jurg Gertsch (University of Bern, Switzerland).
Innovation. We have for the first time discovered that CB2 receptor is highly expressed in (multiple myeloma) cell lines, and also first to discover novel CB2 ligands with therapeutic potential for multiple myeloma treatment (see patents 1,2). A series of selective CB2 inverse agonists with novel chemical scaffolds were synthesized and top 3 compounds showed excellent CB2 binding affinity (< 100 nM) and effective anti-MM activity. All these compounds exhibit good drug-like properties with no or minor toxicity to normal cells.
Significance and current market. Multiple myeloma (multiple myeloma) remains an incurable malignancy with systematic morbidity and a median survival of 3-5 years. It accounts for 10% of all hematological malignancies, characterized by aberrant proliferation of terminally differentiated plasma cells and impairment in apoptosis capacity. Due to the interactions between myeloma cells and cells of the bone marrow microenvironment, the osteolytic bone disease associated with myeloma is inextricably linked with tumor progression. High incidence of bone metastasis in multiple myeloma patients (95-100%) is associated with severe bone pain and pathological fracture (60%), which has been defined as the result of activated osteoclast and suppressed osteoblast. While a diverse spectrum of novel agents has shown therapeutic potential in myeloma clinic, including bortezomib, lenalidomide and arsenic trioxide, however high relapse rates and drug resistance continue to plague these therapies due to blurred multiple myeloma pathogenesis. Thus, novel targets and treatment in multiple myeloma pathogenesis are of critical importance to improve the patient outcomes.
Expertise and know-how. We have identified the new multiple myeloma drug target and also discovered novel drug leads by our established expertise and how-how technologies. Our innovation was based on our recent discovery and the therapeutic hypothesis that cannabinoid receptor-2 (CB2) pathway plays important role in multiple myeloma cell growth and related bone disorder (see patent below). Distinct from cannabinoid receptor-1 (CB1) that expresses in brain neuron system, CB2 has been identified to be expressed exclusively in the immune system, especially on plasma B cells. However, the significance of CB2 signaling pathway in multiple myeloma, or the cancer of plasma B cells, had never been explored as a potential therapeutic target. With many years of research investigations and how-know technologies, we have found that high levels of expression of active CB2 was observed in human multiple myeloma cell lines and primary CD138+ myeloma cells. Our discovered CB2 ligand, phenylacetylamide (PAM, or XIE95), inhibits multiple myeloma growth through cell cycle modulation, mitotic death and cytoskeleton disruption. In particular, our studies show that CB2 gene silencing rescues PAM-induced inhibition of multiple myeloma cell proliferation. In summary, our data demonstrated that targeting CB2 pathway may represent a novel promising strategy for multiple myeloma treatment. Furthermore, it’s been reported that CB2 is expressed in osteoclast and osteoblast as well as their precursor cells. CB2-/- mice showed accelerated age-related trabecular bone loss and cortical expansion. CB2-/- osteoclast number and trabecular osteoblast activity were increased. The role of CB2 pathway in MM-induced bone remodeling, however, is poorly defined. We found that our compound PAM favorably suppressed osteoclast formation in both murine and human osteoclastogenesis. Overall, with our discovery of the abundance of CB2 in multiple myeloma cells and its regulation on immune cell function (e.g. pre-B cell retention, antibody production, etc.), the role of CB2 gene regulation in multiple myeloma pathogenesis and its promising therapeutic target in treatment have tempted us to investigate CB2 and multiple myeloma. Currently, the top hit compounds are under way for animal efficacy and toxicity studies. We are open for collaborations with academics and pharma industries
References:
Xie, X-Q., Feng, RT, and Peng Yang “Novel CB2 Inverse Agonists and Therapeutic Potential for Multiple Myeloma and Osteoporosis Bone Diseases”. (2012) Patent USSN: 61/576,041
Xie, X-Q*., J.Z. Chen and Y.X. Zhang. “Ligands Specific for Cannabinoid Receptor Subtype 2” (2009), WO 2009058377, 2008-US12395, 2007USSN 60/984,461.
Zhang YX, Xie, ZJ, Wang, LR, Lazo, JS, Gertsch, J, Schribeit B, Xie X-Q*: Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor. International Immunopharmacology. 2011;11:1303-10.
Chen, J.; Wang, J.; and Xie, X.-Q.* “GPCR structure-based virtual screening approach for CB2 antagonist search.” J. Chemical Information and Modeling. 2007;47:1626-1637. (100%)
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truthSeeker
Re: Medical Cannabis Treatments?
any luck w/the hemp oil? i've been reading on it quite a bit and it looks hopeful. just seems that there are not a lot of studies on multiple myeloma as multiple myeloma is a popular variety. would love to hear more.
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guiney pig
Re: Medical Cannabis Treatments?
I use medical cannabis for upset stomach, lack of sleep from dex, headaches from dex, overall taking the edge off. I'm on RVD and have not had a stem cell. Cannabis just helps cope and take away the pain .... If your looking for scientific application I cannot help you out but from practical experience, that's my specialty. Hopefully whatever stigma people see you will look past if your just looking for no approval but some type of non-pill medicine that helps. BTW I was on heavy painkillers for 4 years and got off 2 years ago and the cannabis has been more helpful and nonaddictive the entire time. I'd recommend it highly for a cancer patient ... Stay away from pills.
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Barneasada - Name: Mark
- When were you/they diagnosed?: Jan 2007
- Age at diagnosis: 19
Re: Medical Cannabis Treatments?
I have now made RSO oil (Rick Simpson Oil or concentrated cannabinoid oil) for my mother in law who has multiple myeloma. She is in her early 50's and a very non-compliant patient in every possible way....but who we love dearly even though gets us so damn mad someitmes... She is NOT 100% on board with the whole RSO treatment (or any treatment) and only took the oil regularly for about 10 days before she started an extremely toxic chemo regime which knocked her on her ass. She was immediately deathly sick and could not leave bed, ended up in the hospital for a few days, is still recovering at home, and is currently taking a break from the RSO oil.(which is very sedative and can indeed get you a bit "high")
What I can tell you is that during the time she was taking the oil, is that her very severe peripheral neuropathy in her hands and feet, was all but completely eliminated by the RSO oil by about day 3. It was elimated about 20-22 hours a day, and woudl creep in a little just prior to her taking her next daily dose of the oil.. I had read that peripheral neuropathy relief is well known to be eliminated by cannabinoid oil, but I have now witnessed it first hand. Just as importantly to her peripheral neurapathy being eliminated, is that her spirits were extremely lifted and It was like having her old self back again. We had not see her that full of life in many, many months. She was engaged in life and it was very noticeable. Immediately following this latest toxic chemo disaster, all her blood work was taken (which otherwise wasn't suppose to be drawn for another 2 weeks) and to her Doctors surprise some of her cancer numbers had surprisingly went down. I'm not not sure exactly which numbers(though I did ask the patient, but she couldn;t say.,,,like I said, she's not exactly a model patient), but said they couldn't believe the chemo could have possibly worked that fast.......I certainly don't believe it was the chemo. I 100% believe it was the 10 days of RSO oil she had taken. We are regrouping after this last chemo disaster and and she may restart the oil, but again, she's not 100% on board and it s ultimately her decision. If we do go back on the RSO route, I'll come back and post.
What I can tell you is that during the time she was taking the oil, is that her very severe peripheral neuropathy in her hands and feet, was all but completely eliminated by the RSO oil by about day 3. It was elimated about 20-22 hours a day, and woudl creep in a little just prior to her taking her next daily dose of the oil.. I had read that peripheral neuropathy relief is well known to be eliminated by cannabinoid oil, but I have now witnessed it first hand. Just as importantly to her peripheral neurapathy being eliminated, is that her spirits were extremely lifted and It was like having her old self back again. We had not see her that full of life in many, many months. She was engaged in life and it was very noticeable. Immediately following this latest toxic chemo disaster, all her blood work was taken (which otherwise wasn't suppose to be drawn for another 2 weeks) and to her Doctors surprise some of her cancer numbers had surprisingly went down. I'm not not sure exactly which numbers(though I did ask the patient, but she couldn;t say.,,,like I said, she's not exactly a model patient), but said they couldn't believe the chemo could have possibly worked that fast.......I certainly don't believe it was the chemo. I 100% believe it was the 10 days of RSO oil she had taken. We are regrouping after this last chemo disaster and and she may restart the oil, but again, she's not 100% on board and it s ultimately her decision. If we do go back on the RSO route, I'll come back and post.
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truthSeeker
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