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Discussion about multiple myeloma treatments, stem cell transplants, clinical trials, alternative medicines, supplements, and their benefits and side effects.

Re: PostiveChris's RVD / VRD induction therapy

by rick on Sun Jan 01, 2017 12:20 am

Congrats.

Sorry you have had so many recent hiccups, but I believe that you will look back on 2016-17 as we do 2015-16 – a trial by fire, a marathon (with the occasional sprint), a time to redefine yourself.

There are so many (partial) metaphors for this journey.

I called 2016 my year of sadness – and i won't miss it – but it was not without learning or insight or growth.

Wishing you health in 2017.

Wishing you and your wife rest and support.

We are on a break from treatment until January 7th.

It does get better. Happy new year.

rick

rick
Name: rick
Who do you know with myeloma?: husband
When were you/they diagnosed?: nov 2015
Age at diagnosis: 50

Re: PostiveChris's RVD / VRD induction therapy

by Benny on Sun Jan 01, 2017 1:08 pm

Thinking of you and your surgery on Wednesday.

I have labs Tuesday to see if the induction is working. My IgG was so high to start (14000), it has to come down ... I hope.

Here's to a better 2017!

Benny
Name: BM1971
Who do you know with myeloma?: Me
When were you/they diagnosed?: 12/2/16
Age at diagnosis: 45

Re: PostiveChris's RVD / VRD induction therapy

by PositiveChris on Tue Jan 03, 2017 10:56 pm

I'm recovering well from the leg surgery. Still painful, but I'm not taking any pain meds. I report tomorrow morning bright and early for the back surgery. I should be in the hospital for 3-4 days after, and hopefully can get back on my induction during that time.

Benny, I hope your numbers come back great!

PositiveChris
Name: Chris
Who do you know with myeloma?: Myself
When were you/they diagnosed?: 11/28/2016
Age at diagnosis: 42

Re: PostiveChris's RVD / VRD induction therapy

by Benny on Wed Jan 04, 2017 7:58 pm

Chris.

You are a tough guy. I am sure as a patient being in such good shape going into a treatment you will do very well.

My numbers were really good (for me). I don't have my M-spike back, but my IgG dropped from 10342 (so high) to 2580 mg/dL after 1 cycle. My doctor was really happy and it was a nice shot in the arm for me too.

Good luck with the "big" surgery. Keep us posted!

Benny
Name: BM1971
Who do you know with myeloma?: Me
When were you/they diagnosed?: 12/2/16
Age at diagnosis: 45

Re: PostiveChris's RVD / VRD induction therapy

by PositiveChris on Thu Jan 05, 2017 12:21 am

Benny, awesome news! Looks like you're having a great response!

PositiveChris
Name: Chris
Who do you know with myeloma?: Myself
When were you/they diagnosed?: 11/28/2016
Age at diagnosis: 42

Re: PostiveChris's RVD / VRD induction therapy

by PositiveChris on Thu Jan 05, 2017 9:23 pm

It's looking like I'm starting back on my induction next Tuesday. They want to give me more time to recover from surgery and raise my blood counts. Makes sense.

I think they're going to move me over to Kyprolis, Revlimid, and dexamethasone (KRD), and I will provide more detail on that later.

I'm looking forward to getting back on the wagon.

PositiveChris
Name: Chris
Who do you know with myeloma?: Myself
When were you/they diagnosed?: 11/28/2016
Age at diagnosis: 42

Re: PostiveChris's RVD / VRD induction therapy

by rick on Fri Jan 06, 2017 1:54 am

Glad the surgery went well ... and I guess welcome to the KRD team?

My husband starts maintenance on Saturday with Kyprolis and dexamethasone and days 1, 2, 15, and 16, and Revlimid on days 1-21, of a 28 day cycle..

Continued speedy recovery.

rick

rick
Name: rick
Who do you know with myeloma?: husband
When were you/they diagnosed?: nov 2015
Age at diagnosis: 50

Re: PostiveChris's RVD / VRD induction therapy

by Colin on Sat Jan 07, 2017 8:08 am

Hi Chris.

I am having similar problems with constipation.

I was given the following link from the BC Cancer Agency in Canada

http://www.bccancer.bc.ca/family-oncology-network-site/Documents/SuggestionsforDealingwithConstipation.pdf

Increasing the sennoseides helped and I resorted to lactulose to really get to the bottom of it (so to speak).

Colin
Name: Colin Rice
Who do you know with myeloma?: Myself
When were you/they diagnosed?: November 2016
Age at diagnosis: 60

Re: PostiveChris's RVD / VRD induction therapy

by Nancy Shamanna on Sat Jan 07, 2017 10:48 am

Another laxative to try is Lax a Day (polyethylene glycol). I needed to use that when taking Revlimid, but did use Senokot when on induction chemo with Velcade. I found that the Laxaday worked the best, and it was recommended to me by the oncology nurses. Hope that helps!

Nancy Shamanna
Name: Nancy Shamanna
Who do you know with myeloma?: Self and others too
When were you/they diagnosed?: July 2009

Re: PostiveChris's RVD / VRD induction therapy

by Kebo on Wed Jan 11, 2017 1:13 pm

Best of luck with the induction therapy. My induction was RVD – 15 mg Revlimid, 2.6 Velcade twice a week (which they reduced to 2.1 after 3rd week), and 20 mg dexa­metha­sone when I had the Velcade injection. My initial cycles were 2 weeks on, one week off. This was changed after cycle 3 to 3 weeks on and 1 week off, but my Revlimid dosage was reduced to 10 mg. The oncologist had suggested Zometa in addition to RVD, but I didn't want to take it because my bone scan was fine and a friend of mine had a bad experience on it.

On the RVD - First week, I got the hiccups, which lasted on and off for 3 days (ugh!). Also, I ran a slight fever after the first treatment. However, all that cleared up. I started taking the Revlimid in the evening, but I found that in the morning my eyes were really puffy, so I changed to taking it in the morning and that cleared up the puffy eyes.

Also, as with most of you, I do get the Velcade burns from the injections, and it really didn't matter if they did it slow, fast, or somewhere in between. There was always a burn mark. I did experience some constipation; prune juice really helped.

But my results were good. After 2 cycles, no M-spike and all my numbers were in normal range. I kept with the treatment for 5 cycles. I started to get some painful foot neuropathy (now dealing with some planter fasciitis, which I'm sure is somehow related to the treatment), and the oncologist decided to end the treatments. I will be seeing the myeloma specialist in March. Hoping you have a positive reaction to the treatment.

By the way – my myeloma specialist wanted me to do a stem cell transplant, but I declined because I responded so positively to the drug treatment.

Kebo
Name: Kebo
Who do you know with myeloma?: self
When were you/they diagnosed?: 2008
Age at diagnosis: 51

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