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Re: Fenofibrate (Tricor) and multiple myeloma
It's been a while since I last posted my lab results. I continue on a regimen of curcumin and fenofibrate (Tricor). As always, I have no idea if this regimen has helped keep my numbers in check, but I am thankful that my disease doesn't seem to be advancing.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Fenofibrate (Tricor) and multiple myeloma
Multibilly,
I think your graph that tracks your myeloma markers is fantastic. May I ask what program you are using to generate the curves. The blue lines aren't nearly as impressive as the black lines. I am ashamed as an engineer I don't know how to generate one with my data. Was it with Excel or another readily available software package? (It wouldn't surprise me if my smartphone has the capabilities to generate such a graph, urgh). I am only slightly familiar with the sum of least square linear calculations in Excel.
There is no better way to analyze data than with an appropriate graph.
Thanks
I think your graph that tracks your myeloma markers is fantastic. May I ask what program you are using to generate the curves. The blue lines aren't nearly as impressive as the black lines. I am ashamed as an engineer I don't know how to generate one with my data. Was it with Excel or another readily available software package? (It wouldn't surprise me if my smartphone has the capabilities to generate such a graph, urgh). I am only slightly familiar with the sum of least square linear calculations in Excel.
There is no better way to analyze data than with an appropriate graph.
Thanks
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blueblood - Name: Craig
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: March 2014
- Age at diagnosis: 54
Re: Fenofibrate (Tricor) and multiple myeloma
Hi Craig,
The graphs are done in Excel.
The black lines are just trendlines. Just right click on any line graph in Excel and select "Add Trendline". I then select the polynomial trendline option and simply adjust the polynomial order until I get what my eye considers to be a best curve fit for that particular line graph.
The vertical lines are error bars that you can add under the Layout section of Excel. I use error bars with 1 standard deviation to let me know if any of my lab values drift by more than 1 standard deviation in order to give me a heads up that something statistically out of the ordinary might be occurring.
The graphs are done in Excel.
The black lines are just trendlines. Just right click on any line graph in Excel and select "Add Trendline". I then select the polynomial trendline option and simply adjust the polynomial order until I get what my eye considers to be a best curve fit for that particular line graph.
The vertical lines are error bars that you can add under the Layout section of Excel. I use error bars with 1 standard deviation to let me know if any of my lab values drift by more than 1 standard deviation in order to give me a heads up that something statistically out of the ordinary might be occurring.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Fenofibrate (Tricor) and multiple myeloma
Multibilly,
Thank you. You are one intriguing individual.
I've written Excel functions to take a weighted average to track recent sales data. I'm sure Excel can do that too.
Craig
Thank you. You are one intriguing individual.
I've written Excel functions to take a weighted average to track recent sales data. I'm sure Excel can do that too.
Craig
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blueblood - Name: Craig
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: March 2014
- Age at diagnosis: 54
Re: Fenofibrate (Tricor) and multiple myeloma
Multibilly,
I have read every single comment in this thread and you certainly may be on to something using Tricor (fenofibrate) in your regimen. I'm off to my internal medicine doctor tomorrow armed with all of this information, and I certainly plan to start Tricor. What have I got to lose? I'll keep everyone posted on my labs as I join this experiment.
Thanks so much for sharing all of your graphs too. I find them rather comforting since my labs have started bouncing around as well. Keep up the great work in keeping us informed, Multibilly!
I have read every single comment in this thread and you certainly may be on to something using Tricor (fenofibrate) in your regimen. I'm off to my internal medicine doctor tomorrow armed with all of this information, and I certainly plan to start Tricor. What have I got to lose? I'll keep everyone posted on my labs as I join this experiment.
Thanks so much for sharing all of your graphs too. I find them rather comforting since my labs have started bouncing around as well. Keep up the great work in keeping us informed, Multibilly!
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Mellym
Re: Fenofibrate (Tricor) and multiple myeloma
Remember, I'm not just on Tricor. I have also been taking high-dose curcumin (1.8 gram theracurmin twice a day with a 10 mg bioperine pill thrown in with each dose) for nearly 5 years now. And remember to be careful taking Tricor if you are already on a statin such as Lipitor. Rhabdomyolysis is serious business.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Fenofibrate (Tricor) and multiple myeloma
Hi Multibilly, We have the theracurmin also. Each pill is 30 mg. Can I ask how many pills you take at one time?
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Mark T - Name: Mark T
- Who do you know with myeloma?: wife
- When were you/they diagnosed?: 4/2016
- Age at diagnosis: 60
Re: Fenofibrate (Tricor) and multiple myeloma
I use 600 mg capsules. So, I take 3 x 600 mg with 10 mg bioperine twice a day.
Most thearcurmin is labeled with the amount of "theracurumin" it contains and then a secondary listing of the turmeric rhizome that this represents. The ratio of theracurmin to the amount of the tumeric rhizome it yields is always 10x since it all comes from the same manufacturer in Japan (Theravalues). Therefore, a typical 600 mg theracurmin pill will contain 60 mg of the tumeric rhizome (Curcuma longa). But the labeling on the bottles isn't always consistent.
I'm really not sure that theracurmin is really any better than any another curcumin formulation, but I tend to believe that it "might" potentially be more bioavailable than regular curcumin since it certainly is a more miscible formulation than standard curcumin (try dissolving regular curcumin into water...they just don't mix. That's why you sometimes hear of folks taking curcumin with things like yogurt and other fat-containing foods). I used to take about 8g of Doctor's Best curcumin daily. I hedge my bet by including a bioperine (black pepper extract) pill with my dose.
Like most supplements, most of the claims for curcumin potency are pretty unscientific, full of hype and the products are endorsed by what I think are questionable holistic doctors that seem to be paid by the product's manufacturers. So, my choice of taking theracurmin with a bioperine pill was largely just a crapshoot. The dose I chose was equally unscientific.
Most thearcurmin is labeled with the amount of "theracurumin" it contains and then a secondary listing of the turmeric rhizome that this represents. The ratio of theracurmin to the amount of the tumeric rhizome it yields is always 10x since it all comes from the same manufacturer in Japan (Theravalues). Therefore, a typical 600 mg theracurmin pill will contain 60 mg of the tumeric rhizome (Curcuma longa). But the labeling on the bottles isn't always consistent.
I'm really not sure that theracurmin is really any better than any another curcumin formulation, but I tend to believe that it "might" potentially be more bioavailable than regular curcumin since it certainly is a more miscible formulation than standard curcumin (try dissolving regular curcumin into water...they just don't mix. That's why you sometimes hear of folks taking curcumin with things like yogurt and other fat-containing foods). I used to take about 8g of Doctor's Best curcumin daily. I hedge my bet by including a bioperine (black pepper extract) pill with my dose.
Like most supplements, most of the claims for curcumin potency are pretty unscientific, full of hype and the products are endorsed by what I think are questionable holistic doctors that seem to be paid by the product's manufacturers. So, my choice of taking theracurmin with a bioperine pill was largely just a crapshoot. The dose I chose was equally unscientific.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Fenofibrate (Tricor) and multiple myeloma
Thank you for the reply and explanation Multibilly. I had visions of you taking curcumin pills by the handful 
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Mark T - Name: Mark T
- Who do you know with myeloma?: wife
- When were you/they diagnosed?: 4/2016
- Age at diagnosis: 60
Re: Fenofibrate (Tricor) and multiple myeloma
There's a new paper out titled "In Vitro Apoptosis Induction by Fenofibrate in Lymphoma and Multiple Myeloma." It's from the July issue of a journal called Anticancer Research. The abstract follows:
Background / Aim:
Recent innovations in the treatment of multiple myeloma have enriched our therapeutic repertoire regarding the treatment of multiple myeloma during the last decades. However, despite today's therapies many multiple myeloma patients experience relapse of disease and eventually remain incurable. Wnt/β-catenin signaling has been demonstrated in lymphoma and multiple myeloma, rendering related signaling molecules promising therapeutic targets. Fenofibrate, an extensively scrutinized and widely used drug for primary hypercholesterolemia or mixed dyslipidemia, has proven anticarcinogenic properties mediated by peroxisome proliferator-activated receptor-alpha (PPARα) agonism, thereby also influencing WNT-associated signaling molecules.
Materials and Methods:
The antitumor apoptotic effect of fenofibrate at doses ranging from 0.1-200 μM was investigated on a total of seven human, two murine myeloma / lymphoma cell lines and two healthy control cell lines, as determined by 3'3-Dihexyloxacarbocyanine iodide (DiOC6) and propidium iodide (PI) staining in flow cytometry.
Results:
Fenofibrate significantly reduced viability due to apoptosis induction in all investigated myeloma and lymphoma cell lines in a dose-dependent manner, whereas healthy control cells were less sensitive.
Conclusion:
Our results provide a rationale for future in vitro and in vivo studies with fenofibrate as a safe and well-tolerated agent in multiple myeloma and lymphoma treatment.
More evidence that you may well be ahead of the crowd on this one, Multibilly!
Reference:
Schmeel, LC, et al, "In Vitro Apoptosis Induction by Fenofibrate in Lymphoma and Multiple Myeloma," Anticancer Research, July 2016 (abstract)
Background / Aim:
Recent innovations in the treatment of multiple myeloma have enriched our therapeutic repertoire regarding the treatment of multiple myeloma during the last decades. However, despite today's therapies many multiple myeloma patients experience relapse of disease and eventually remain incurable. Wnt/β-catenin signaling has been demonstrated in lymphoma and multiple myeloma, rendering related signaling molecules promising therapeutic targets. Fenofibrate, an extensively scrutinized and widely used drug for primary hypercholesterolemia or mixed dyslipidemia, has proven anticarcinogenic properties mediated by peroxisome proliferator-activated receptor-alpha (PPARα) agonism, thereby also influencing WNT-associated signaling molecules.
Materials and Methods:
The antitumor apoptotic effect of fenofibrate at doses ranging from 0.1-200 μM was investigated on a total of seven human, two murine myeloma / lymphoma cell lines and two healthy control cell lines, as determined by 3'3-Dihexyloxacarbocyanine iodide (DiOC6) and propidium iodide (PI) staining in flow cytometry.
Results:
Fenofibrate significantly reduced viability due to apoptosis induction in all investigated myeloma and lymphoma cell lines in a dose-dependent manner, whereas healthy control cells were less sensitive.
Conclusion:
Our results provide a rationale for future in vitro and in vivo studies with fenofibrate as a safe and well-tolerated agent in multiple myeloma and lymphoma treatment.
More evidence that you may well be ahead of the crowd on this one, Multibilly!
Reference:
Schmeel, LC, et al, "In Vitro Apoptosis Induction by Fenofibrate in Lymphoma and Multiple Myeloma," Anticancer Research, July 2016 (abstract)
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Mike F - Name: Mike F
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: May 18, 2012
- Age at diagnosis: 53
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