Hi,
New here. Had a battery of blood work and procedures completed in January and February. New blood work just completed. What do the numbers say?
Serum calcium: 9.6 mg/dL 8.8-10.2
Serum creatnine: 1.3 mg/dL 0.60-1.50
IgA: 72.7 mg/dL 60.0-350.0
IgG: 589.0 mg/dL L 700.0-1600.0
IgM: <16.0 mg/dL L 40.0-280.0
Serum HGB: 13.2 g/dL 13.0-17.0
Kappa FLC-Serum: 0.13 mg/dL L 0.33-1.94
Lambda FLC-Serum: 60.10 mg/dL H 0.57-2.63
UIE: Lambda Bence Jones protein identified
Complete Bone X-Ray Survey: Negative
SPEP: All normal except Gamma: 0.46 g/dL L 0.70-1.50
(Note: With hypogammaglobinemia, although not seen in this study, a free light chain paraprotein cannot be excluded.)
UPE 24-hr: 65 mg/24 0-165.0
SIE: Suspicious for a small lambda free light chain paraprotein
Bone Marrow Biopsy: 14% plasma cells - Result was not conclusive when considering all other data.
In the past week I have had severe back and chest/rib pains. And at times have been retaining fluid in the ankles.
Any insight?? Greatly appreciated!
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Not diagnosed - what do my numbers mean?
Last edited by Ben on Sun Jun 14, 2015 10:22 pm, edited 7 times in total.
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Ben - Name: Ben
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: 2015
- Age at diagnosis: 53
Re: Not diagnosed - what do my numbers mean?
Hi Ben,
Welcome to the forum.
Are you going to be seeing the doctor that ordered these tests soon to get his/her take on these results?
In the meantime, we can try and help you, but we need a bit more information first:
What are the units of measure for all the numbers you posted (mg/dL, etc)? The lab results should also include the normal reference ranges for most of the values you posted. Please also include those ranges.
Did the kappa and lambda numbers come from a blood serum free light chain test or from a 24-hour urine test where you collected your urine over the span of a day?
When you say "Bone Scan", did you really mean a "Bone Scan", or did you have a whole body skeletal survey (xray), MRI or PET/CT and you are simply calling that test a "Bone Scan"? Bone Scans are not used to look for problems associated with multiple myeloma, but Xray surveys, MRIs and PET/CT scans are.
If they did a bone marrow biopsy to measure your plasma cell %, the biopsy report almost certainly would have commented on whether the appearance of the plasma cells were suggestive of multiple myeloma or some other related disease. Are you looking at that report? While a lot of that report will look like Greek to the average person, it should provide a understandable interpretation of the findings somewhere in the report.
Lastly, did they also run a serum Immunoxifxation (IFE) and a Serum Protein Electrophoresis (SPEP) test? Do you have those results?
Welcome to the forum.
Are you going to be seeing the doctor that ordered these tests soon to get his/her take on these results?
In the meantime, we can try and help you, but we need a bit more information first:
What are the units of measure for all the numbers you posted (mg/dL, etc)? The lab results should also include the normal reference ranges for most of the values you posted. Please also include those ranges.
Did the kappa and lambda numbers come from a blood serum free light chain test or from a 24-hour urine test where you collected your urine over the span of a day?
When you say "Bone Scan", did you really mean a "Bone Scan", or did you have a whole body skeletal survey (xray), MRI or PET/CT and you are simply calling that test a "Bone Scan"? Bone Scans are not used to look for problems associated with multiple myeloma, but Xray surveys, MRIs and PET/CT scans are.
If they did a bone marrow biopsy to measure your plasma cell %, the biopsy report almost certainly would have commented on whether the appearance of the plasma cells were suggestive of multiple myeloma or some other related disease. Are you looking at that report? While a lot of that report will look like Greek to the average person, it should provide a understandable interpretation of the findings somewhere in the report.
Lastly, did they also run a serum Immunoxifxation (IFE) and a Serum Protein Electrophoresis (SPEP) test? Do you have those results?
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Not diagnosed - what do my numbers mean?
Hi Multibilly,
I believe I have added the information you thought would be more helpful.
Ben
I believe I have added the information you thought would be more helpful.
Ben
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Ben - Name: Ben
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: 2015
- Age at diagnosis: 53
Re: Not diagnosed - what do my numbers mean?
On your SPEP test, was there an entry that talked about an "abnormal protein band", paraprotein, M-spike, monoclonal protein, M-protein, etc?
You have a pretty high lambda free light chain value. There is also a number known as the free light chain ratio, which is lambda/kappa in your situation. Your ratio is ~ 460, which is also pretty high.
Your elevated lambda value and elevated free light chain ratio, coupled with your 14% plasma cell reading and your SIE (aka IFE) detecting lambda paraprotein would suggest to me that you ought to seek out a multiple myeloma specialist to get his/her take on your lab results. If you let us know what city you live in, folks on this forum can make recommendations on where to find such a specialist.
Xrays are no longer considered the standard for initial diagnosis of multiple myeloma. MRIs and PET/CTs are now the standard. If you are experiencing bone pain, I might suggest that you ask your doctor to run a full body MRI or PET/CT.
You have a pretty high lambda free light chain value. There is also a number known as the free light chain ratio, which is lambda/kappa in your situation. Your ratio is ~ 460, which is also pretty high.
Your elevated lambda value and elevated free light chain ratio, coupled with your 14% plasma cell reading and your SIE (aka IFE) detecting lambda paraprotein would suggest to me that you ought to seek out a multiple myeloma specialist to get his/her take on your lab results. If you let us know what city you live in, folks on this forum can make recommendations on where to find such a specialist.
Xrays are no longer considered the standard for initial diagnosis of multiple myeloma. MRIs and PET/CTs are now the standard. If you are experiencing bone pain, I might suggest that you ask your doctor to run a full body MRI or PET/CT.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Not diagnosed - what do my numbers mean?
I added the note on the SPEP on the original message. As for where I live - l live between Flint and Lansing, Michigan.
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Ben - Name: Ben
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: 2015
- Age at diagnosis: 53
Re: Not diagnosed - what do my numbers mean?
Yeah, I saw the SPEP results you posted, but the SPEP often calls out a separate entry (sometimes with comments) that talks about what I inquired about.
IF you do have multiple myeloma, it seems like you may have a version that is limited to expressing only light chains in your blood since the immunofixation test didn't mention anything about monoclonal heavy chains (immunoglobulins) and all your immunoglobulin levels are within the normal range. This happens with something like 20% of multiple myeloma patients.
But a multiple myeloma specialist really needs to make the determination if multiple myeloma is even in play here.
The advanced search feature of this forum is your friend for finding info, including specialists in multiple myeloma. Here is one thread from a search
https://myelomabeacon.org/forum/physician-in-michigan-for-father-with-mgus-t2515.html
You can also see a listing here:
https://myelomabeacon.org/resources/treatment-centers/#Michigan
Good luck with this.
IF you do have multiple myeloma, it seems like you may have a version that is limited to expressing only light chains in your blood since the immunofixation test didn't mention anything about monoclonal heavy chains (immunoglobulins) and all your immunoglobulin levels are within the normal range. This happens with something like 20% of multiple myeloma patients.
But a multiple myeloma specialist really needs to make the determination if multiple myeloma is even in play here.
The advanced search feature of this forum is your friend for finding info, including specialists in multiple myeloma. Here is one thread from a search
https://myelomabeacon.org/forum/physician-in-michigan-for-father-with-mgus-t2515.html
You can also see a listing here:
https://myelomabeacon.org/resources/treatment-centers/#Michigan
Good luck with this.
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
6 posts
• Page 1 of 1