To submit a sample for second review, it is variable from center to center.

For example, to submit to MD Anderson, the way to do it is to have you or your oncologist call the "askMDAnderson" number for general information at the center (1-877-632-6789), and they can coordinate.

An allo transplant is a major decision, unlike choices for induction therapy or auto transplant. There must be a clear reason to do an allo, or something unique about your myeloma – such as high risk disease – to warrant a discussion of an allo transplant. I would strongly recommend talking to sever...

It is common to see low blood counts with Pomalyst, especially after measuring the day after completion of Pomalyst. This is expected and I fully anticipate it will improve after a 7-day rest.

There is nothing to worry about and it should not affect subsequent therapy.

All the best.

The blood work and urine work look reassuring. The actual blood levels of the free kappa and lambda light chains would be important. It's also important to find out why you are so anemic and have low iron levels. Young females may be iron deficient from monthly menses, and I agree with iron replacem...

That is uncommon, but we do see concurrent diagnosis. How­ever, I would absolutely recom­mend a second opinion in these type of situations, to have the biopsy slides reviewed at a tertiary care center, and to have them seen by a lymphoma / myeloma specialist. You should ask your physician if there a...

This is an interesting article. However, these findings have not been further validated, and we have other good tools to predict progression. In addition, the article does not apply to your situation, as it only looked at B2M at the time of diagnosis. It did not look at serial changes in patients' B...

It is im­por­tant to under­stand why you are ex­peri­encing short­ness of breath (dyspnea). Is this due to pul­mo­nary infiltrate, or heart volume overload? I would suggest a chest xray and potentially an echo­cardiogram of the heart. We can treat with diuretics or antibiotics based on the reason fo...

This is certainly a highly challenging situation. I agree with the suggestion to get a second opinion and it appears you are seeing a myeloma specialist. There is no clear standard approach in a situation like this and there are high risks associated with allo transplantation, so it is important tha...

Sorry for the confusion.

I would suggest an amyloidosis workup if there is a significant amount of proteinuria that is not otherwise explained. A small amount of proteinuria, which is common, does not require an amyloidosis workup.

CRP is a protein that can be elevated in many different states, including inflammation. It is also correlated with IL-6 levels. IL6 is a protein that promotes survival / growth of myeloma cells. Ultimately, as the disease responds to therapy, CRP levels may fall. However, there is no significant uti...