Can someone tell me what this means:
"Albumin and traces of all serum globulin fractions are present in the urine consistent with a predominantly non-selective proteinuria pattern. Polyclonal immunostaining is present with no definitive evidence of monoclonal immunoglobulin or free light chains."
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Re: Urine immunofixation results - making sense of them
Hey Andrew,
As always, I'm not a doc, so please check with yours.
Proteinuria simply means you are spilling excess protein into your urine, which "might" suggest a kidney issue. Are all your kidney serum markers normal (creatinine, albumin, etc)?
"Non-selective" proteinuria means that you have a range of different sized proteins in your urine (including big ones like immunoglobulins), so your kidneys aren't being selective about the size of the protein they are passing to your urine.
But note that I've had both minor amounts of proteinuria (protein in the urine) and hematuria (blood in the urine) come and go over the years (well before I had SMM). After many tests (CT, kidney biopsy, cystoscopy, serum tests, etc), my docs just wrote those findings off as being both idiopathic and transient.
Again, your doc is really the one that should comment on this.
As always, I'm not a doc, so please check with yours.
Proteinuria simply means you are spilling excess protein into your urine, which "might" suggest a kidney issue. Are all your kidney serum markers normal (creatinine, albumin, etc)?
"Non-selective" proteinuria means that you have a range of different sized proteins in your urine (including big ones like immunoglobulins), so your kidneys aren't being selective about the size of the protein they are passing to your urine.
But note that I've had both minor amounts of proteinuria (protein in the urine) and hematuria (blood in the urine) come and go over the years (well before I had SMM). After many tests (CT, kidney biopsy, cystoscopy, serum tests, etc), my docs just wrote those findings off as being both idiopathic and transient.
Again, your doc is really the one that should comment on this.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Urine immunofixation results - making sense of them
Your body makes many different types of protein. The language as your quoted describes when various different types of proteins are seen and not just the myeloma protein. This can be seen in patients with, for example, hypertension or diabetes, and it is reassuring that there is no myeloma- related protein.
We also worry about amyloidosis when we have significant proteinuria and, based on the proteinuria, should be part of the potential list of causative factors.
We also worry about amyloidosis when we have significant proteinuria and, based on the proteinuria, should be part of the potential list of causative factors.
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Dr. Jatin Shah - Name: Jatin Shah, M.D.
Beacon Medical Advisor
Re: Urine immunofixation results - making sense of them
Thank you for the reply, doctor, but I am confused about the amyloidosis comment. Do you feel that these results require further follow-up on that point?
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goldmine848 - Name: Andrew
- When were you/they diagnosed?: June 2013
- Age at diagnosis: 60
Re: Urine immunofixation results - making sense of them
Sorry for the confusion.
I would suggest an amyloidosis workup if there is a significant amount of proteinuria that is not otherwise explained. A small amount of proteinuria, which is common, does not require an amyloidosis workup.
I would suggest an amyloidosis workup if there is a significant amount of proteinuria that is not otherwise explained. A small amount of proteinuria, which is common, does not require an amyloidosis workup.
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Dr. Jatin Shah - Name: Jatin Shah, M.D.
Beacon Medical Advisor
5 posts
• Page 1 of 1