A group of multiple myeloma experts from the International Myeloma Working Group recently published a review of management strategies for drug-induced peripheral neuropathy in patients with multiple myeloma.

This Beacon article, the first in a three-part series describes peripheral neuropathy and summarizes the symptoms of drug-induced neuropathy as well as the risk of developing neuropathy associated with myeloma therapies.

A second Beacon article will discuss the experts’ recommendations for the treatment of drug-induced peripheral neuropathy, and a third article will summarize their recommendations for prevention of peripheral …

The results of a recent Phase 2 clinical trial comparing four Velcade-based combination therapies in newly diagnosed multiple myeloma patients show that a four-drug combination containing Velcade, Revlimid, cyclophosphamide, and dexamethasone led to similarly high response rates as the three-drug regimens, but resulted in a higher rate of side effects.

“We were hoping to see more activity at the same level of toxicity as the three-drug combination, but the result was similar efficacy at higher toxicity,” said Dr. Shaji Kumar of the Mayo Clinic in Rochester, Minnesota, and lead investigator of the …

Results of a small Phase 2 study show that the four-drug combination therapy of Revlimid, Velcade, Doxil, and dexamethasone may be an effective and tolerable treatment option for relapsed and refractory multiple myeloma patients.

According to the study investigators, the four-drug regimen compares favorably to the three-drug combination without Revlimid in that it improves response rates without a significant increase in side effects.

The investigators recommend that future trials further investigate the number and specific types of previous treatments to identify those in which the Revlimid, Velcade, Doxil, and dexamethasone combination may …

Many new and promising re­search devel­op­ments oc­curred in the field of mul­ti­ple myeloma during 2011. Over the course of the year, The Myeloma Beacon pub­lished nearly 100 articles on im­por­tant myeloma-related stud­ies.

To identify the most im­por­tant of these stud­ies from 2011, The Myeloma Beacon surveyed lead­ing physicians and re­searchers in the field.  They were asked to name the three peer-reviewed journal articles pub­lished in 2011 and the three conference pre­sen­ta­tions from 2011 that have the most im­por­tant findings or implications relating to mul­ti­ple myeloma.

Their selections for the most im­por­tant journal …

The results of a small Phase 2 study indicate that sequential mainte­nance therapy involving six months of Velcade followed by six months of thalidomide is both effective and tolerable in multiple myeloma patients who have received a stem cell transplant.

The Phase 2 trial was carried out recently at the City of Hope National Medical Center in Duarte, California.

Many patients in the trial experienced peripheral neuropathy (nerve damage that causes pain and tingling in the extremities).

However, the City of Hope researchers believe a key result of their study is that …

Results from a recent German analysis suggest that Velcade-based treatment both before and after stem cell transplantation leads to better survival outcomes than treatment without Velcade in multiple myeloma patients with a deletion in chromosome 17.

The German analysis used data from a Phase 3 clinical trial in which some patients with chromosomal abnormalities were treated with Velcade (bortezo­mib)-based therapy, while others were not.

For all types of chromosomal abnormalities, survival was similar or better for patients in the trial who received Velcade-based therapy.

In particular, though, patients with a deletion …