Articles tagged with: TRAIL
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Every-Other-Day G-CSF Is Just As Effective As Daily G-CSF – Results from a recent Turkish study indicate that every-other-day administration of granulocyte colony-stimulating factor (G-CSF) is just as effective as daily administration following stem cell transplantation. Additionally, every-other-day administration was found to be safe and resulted in a significant reduction in drug costs, according to the investigators. The study included 47 patients with lymphoma or myeloma who underwent a stem cell transplant. Half of the patients received G-CSF every day, while the other half received G-CSF every other day, after stem cell transplantation until their white blood cell counts recovered. The researchers found that the frequency of G-CSF administration did not affect the amount of time until white blood cell counts recovered. There also were no significant differences in hospitalization time, rates of infection, and transfusion requirements in patients who received daily G-CSF compared to every other day G-CSF. For more information, please see the study in Transfusion and Apheresis Science (abstract).
Partial Deletion Of Chromosome 8 May Be Common In Multiple Myeloma – Results from a small French study indicate that it is common for multiple myeloma patients to have myeloma cells that are missing part of chromosome 8. Specifically, the study investigators found that among 37 myeloma patients, 22 percent had myeloma cells that were missing a region of the short arm of chromosome 8 (technically called 8p21.3 deletion). This chromosomal region contains the DNA that is used to make proteins called TRAIL receptors. These receptors play an important role in cell death. When their corresponding chromosomal region is missing, the cell cannot make TRAIL receptors, and abnormal growth of the cells occurs. The researchers found that most of the patients who had the chromosome 8 deletion also had other chromosomal abnormalities commonly associated with myeloma. For more information, please see the study in Medical Oncology (abstract).
Hepatitis B Infection May Impact Survival Of Myeloma Patients Who Receive Stem Cell Transplants – Results of a retrospective Chinese study found that myeloma patients who also have hepatitis B typically have shorter survival following stem cell transplantation, compared to myeloma patients who do not have hepatitis B. Hepatitis B is a viral infection of the liver that can cause damage and scarring to the liver, liver cancer, and liver failure. The study included 70 myeloma patients, 34 of whom also had hepatitis B. After stem cell transplantation using their own stem cells, the three-year overall survival rates were 35 percent for those who also had hepatitis B and 85 percent for those who did not have hepatitis B. The researchers suggest that hepatitis B antiviral treatment may reduce the negative impact hepatitis appears to have on survival. For more information, see the study in Tumor Biology (abstract).
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Results from three Chinese clinical trials indicate that the investigational drug circularly permuted TRAIL may be effective alone or in combination with thalidomide in relapsed and refractory multiple myeloma patients.
However, further testing of the drug is necessary to determine its optimal dose.
Dr. Wenming Chen from the Chaoyang Hospital of Capital Medical University in Beijing presented the findings from the three studies last week at the American Society of Hematology (ASH) annual meeting in Atlanta.
Circularly Permuted TRAIL (CPT) is being developed by Beijing Sunbio Biotech as a treatment for multiple …
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This year’s American Society of Hematology (ASH) annual meeting, which is being held in Atlanta, began yesterday and goes through Tuesday.
Today’s myeloma-related presentations began this afternoon with three sessions of oral presentations. Two of the sessions focused on results from clinical trials, most of which studied drugs that are still under development as potential treatments for multiple myeloma. The third session, which focused on the biology of myeloma, ran simultaneously with one of the sessions about clinical trial results.
This article will summarize the first oral session about multiple myeloma treatments, …
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During the upcoming annual meeting of the American Society of Hematology (ASH), which will be held December 8 through 11 in Atlanta, results will be presented from clinical trials involving a number of potential new drugs under development for the treatment of multiple myeloma.
In particular, results for newer, lesser known agents that are in the early stages of clinical development will take center stage. These agents include ARRY-520 (filanesib), BHQ880, circularly permuted TRAIL, daratumumab, dinaciclib, lorvotuzumab mertansine, oprozomib, and tabalumab.
According to the recently …
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INNO-206 Shows Activity Against Myeloma - Results of a preclinical study show that the investigational drug INNO-206 inhibits blood vessel formation and reduces cell growth in myeloma cell lines. The drug showed these effects when tested alone; additionally it enhanced the efficacy of Velcade (bortezomib) when tested in combination. INNO-206 is a derivative of the chemotherapy agent doxorubicin (Adriamycin). This study also showed that INNO-206 was safer in mice than doxorubicin and therefore could be administered at higher doses. For information, please see the study in Clinical Cancer Research (abstract).
TRAIL-Doxorubicin Combination May Eradicate Myeloma Cells – Results of a preclinical study show that a combination of doxorubicin and TRAIL, a protein that induces cell death, was able to eradicate myeloma cell lines. In particular, the TRAIL-doxorubicin combination successfully eliminated cells that are implicated in tumor initiation as well as tumor growth. According to the study investigators, these findings offer a promising new approach to finding a cure for multiple myeloma. For more information, please see the study in PloS One.
Relatives Of Multiple Myeloma Patients Have Increased Risk Of MGUS – Results of a study conducted at the Mayo Clinic indicate that first-degree relatives of multiple myeloma patients are 3.4 times as likely to develop light-chain monoclonal gammopathy of undetermined significance (MGUS) compared to the general population. A previous study also showed that these relatives are at an increased risk of developing heavy-chain MGUS. For more information, please see the study in the British Journal of Hematology (abstract).
IMF Myeloma Workshop For Patients And Families – The International Myeloma Foundation (IMF) will be hosting a workshop for multiple myeloma patients and their families on June 23 in Milwaukee, WI. Dr. Ayman Saad from the Medical College of Wisconsin, Dr. Natalie Callander from the University of Wisconsin School of Medicine, and nurse Tiffany Richards from the MD Anderson Cancer Center in Houston will speak about topics including treatment options, managing side effects, and local clinical trials. For more information or to register, please visit the IMF website.
For a more detailed listing of myeloma-related events, please check the Myeloma Beacon Events Calendar.
