Articles tagged with: SAR650984

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[ by | May 31, 2014 9:17 pm | 3 Comments ]
ASCO 2014 Multiple Myeloma Update – Day One

This year’s American Society of Clinical Oncology (ASCO) annual meeting began yester­day morning in Chicago and will run through Tuesday.

Myeloma-related pre­sen­ta­tions were made during two sessions yes­ter­day.

One session was designed to better educate physicians about per­son­al­ized ther­apy for elderly patients with lymphoid malig­nan­cies. During that session, Dr. Tanya Marya Wildes from the Washington University School of Medicine in St. Louis talked about how to navigate treat­ment options for older multiple myeloma patients.

The key myeloma-related re­search pre­sented yesterday was made public during a poster session in the afternoon about studies …

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[ by | May 15, 2014 1:01 pm | 5 Comments ]
Latest Myeloma Research To Be Presented At The American Society Of Clinical Oncology Annual Meeting (ASCO 2014)

The American Society of Clinical Oncology will hold its 50th annual meet­ing May 30 through June 3 in Chicago.

Similar to pre­vi­ous years, more than 25,000 physicians and re­searchers from all over the world are ex­pec­ted to attend the five-day meeting to dis­cuss the current re­search in cancer treat­ment and care.

During the meeting, there will be pre­sen­ta­tions about all areas of cancer, in­clud­ing many focused specifically on multiple myeloma. The ASCO website cur­rently lists in­for­ma­tion about more than 60 myeloma-related studies (included under either the "multiple myeloma" or "plasma cell …

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[ by | Mar 1, 2014 5:56 pm | 2 Comments ]
The Top Myeloma Research Of 2013

The year 2013 is likely to be remembered as a very good year when it comes to re­search related to multiple myeloma.

Previous years have witnessed re­search shedding new light on existing my­e­lo­ma ther­a­pies, as well as addi­tional re­search about poten­tial new ther­a­pies.

But, in the past, most of the im­por­tant new ther­a­pies that were being re­searched were from existing classes of ther­apy, making them less likely to offer dramatic im­prove­ments in the treat­ment of the dis­ease.

In 2013, not only was there more re­search about existing ther­a­pies, and more re­search about …

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[ by | Dec 17, 2013 5:18 pm | 2 Comments ]
SAR650984 Shows Encouraging Early Results For Heavily Pretreated Multiple Myeloma (ASH 2013)

Initial results from a Phase 1 clin­i­cal trial show prom­ise for SAR650984 as a thera­peutic option for heavily pre­treated multiple myeloma patients.

SAR650984 is one of several poten­tial new anti-myeloma agents for which clin­i­cal results were first pre­sented at the American Society of Hematology (ASH) meeting last week.

The results were pre­sented by Dr. Joseph Mikhael from the Mayo Clinic in Scottsdale, Arizona, who told The Beacon, “This drug was hands down the most promising new agent at ASH for myeloma.”

Dr. Mikhael further ex­plained, “The re­sponse­ rates were impressive, especially in …

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[ by | Dec 13, 2013 9:16 pm | 3 Comments ]
ASH 2013 Multiple Myeloma Update - Day Three: Morning Oral Sessions

This Monday was the third day of the 2013 American Society of Hema­tol­o­gy (ASH) annual meeting, which was held in New Orleans.

More than any other day of the conference, Monday was packed with im­por­tant myeloma pre­sen­ta­tions, from 7:00 in the morning until almost 8:00 in the eve­ning.

This ASH update will summarize the oral pre­sen­ta­tion sessions about treat­ment-related myeloma studies that were held Monday morning. An ASH update that was pub­lished on Wednesday focused on the sessions that were held Monday afternoon and evening.

Monday morning started with three simultaneous …

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[ by | Nov 15, 2013 10:52 pm | 3 Comments ]
ASH 2013 Preview: The Newest Multiple Myeloma Treatments On The Horizon

At this year’s American Society of Hematology (ASH) meeting, which will be held in early De­cem­ber, more than 100 oral pre­sen­ta­tions and about 400 poster pre­sen­ta­tions will summarize re­search focused on multiple myeloma.

Abstracts for these pre­sen­ta­tions are now avail­able.

During the next several weeks, The Beacon will pub­lish a series of arti­cles pre­viewing the myeloma-related studies from the ASH meeting that are of par­tic­u­lar interest.

Each of the articles will cover abstracts related to a specific topic, such as new treat­ments under de­vel­op­ment, current treat­ments, stem cell trans­plan­ta­tion, prog­nos­tic factors, and …

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[ by | Jan 14, 2013 11:25 am | 6 Comments ]

HHV-6 Infection May Be Common After Stem Cell Transplantation – Results of a retro­spec­tive­ Israeli study in­di­cate that human herpesvirus 6 (HHV-6) in­fec­tion is common in multiple myeloma patients after own (autologous) stem cell trans­plantation. HHV-6 is a family of two viruses that are present, but inactive, in most adults. If the virus be­comes active in an adult, the resulting in­fec­tion can cause pneu­monia, sup­pres­sion of blood cell pro­duc­tion, and inflammation of the brain. The Israeli re­searchers found that 16 per­cent of patients in their study devel­oped an HHV-6 in­fec­tion after stem cell trans­plantation. The rate of infec­tion was higher in patients who had re­ceived initial ther­apy with Velcade (bor­tezomib) and dexamethasone (Decadron) (20 per­cent) com­pared to those who re­ceived thalidomide (Thalomid) and dexa­meth­a­sone (10 per­cent). The re­searchers rec­om­mend further studies to de­ter­mine if Velcade plays a role in the devel­op­ment in­fec­tion due to the virus. For more infor­ma­tion, please see the study in the journal Bone Marrow Research (full text).

Iron Supplementation May Increase Velcade’s Efficacy – Results of a small Italian pre­clin­i­cal study show that iron supple­mentation may in­crease the efficacy of Velcade. The Italian re­searchers found that iron supple­mentation promoted protein oxidation and in­creased myeloma cell death. They concluded that modi­fi­cation of the iron status in multiple myeloma patients may be worth con­sidering to im­prove the efficacy of pro­te­a­some in­hib­i­tors such as Velcade. For more in­for­ma­tion, please see the study in Haemato­logica (full text).

Phase 1 Clinical Trial To Study SAR650984 Plus Revlimid In Previously-Treated Myeloma Patients – The pharma­ceu­tical com­pany Sanofi-Aventis is starting a Phase 1 trial of SAR650984 in com­bi­na­tion with Rev­limid (lena­lido­mide) and dexa­meth­a­sone in re­lapsed and re­frac­tory multiple myeloma patients. Myeloma patients must have re­ceived at least two prior ther­a­pies to be able to par­tic­i­pate in the trial. SAR650984 belongs to the same class of drugs as elotuzumab and daratumumab, called mono­clonal anti­bodies. Monoclonal anti­bodies work by identifying proteins on the surface of myeloma cells and signal­ing for the immune sys­tem to destroy the cancer cells. For more in­for­ma­tion, in­clud­ing trial locations, please see the clinical trial description.