Articles tagged with: SAR650984
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This year’s American Society of Clinical Oncology (ASCO) annual meeting began yesterday morning in Chicago and will run through Tuesday.
Myeloma-related presentations were made during two sessions yesterday.
One session was designed to better educate physicians about personalized therapy for elderly patients with lymphoid malignancies. During that session, Dr. Tanya Marya Wildes from the Washington University School of Medicine in St. Louis talked about how to navigate treatment options for older multiple myeloma patients.
The key myeloma-related research presented yesterday was made public during a poster session in the afternoon about studies …
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The American Society of Clinical Oncology will hold its 50th annual meeting May 30 through June 3 in Chicago.
Similar to previous years, more than 25,000 physicians and researchers from all over the world are expected to attend the five-day meeting to discuss the current research in cancer treatment and care.
During the meeting, there will be presentations about all areas of cancer, including many focused specifically on multiple myeloma. The ASCO website currently lists information about more than 60 myeloma-related studies (included under either the "multiple myeloma" or "plasma cell …
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The year 2013 is likely to be remembered as a very good year when it comes to research related to multiple myeloma.
Previous years have witnessed research shedding new light on existing myeloma therapies, as well as additional research about potential new therapies.
But, in the past, most of the important new therapies that were being researched were from existing classes of therapy, making them less likely to offer dramatic improvements in the treatment of the disease.
In 2013, not only was there more research about existing therapies, and more research about …
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Initial results from a Phase 1 clinical trial show promise for SAR650984 as a therapeutic option for heavily pretreated multiple myeloma patients.
SAR650984 is one of several potential new anti-myeloma agents for which clinical results were first presented at the American Society of Hematology (ASH) meeting last week.
The results were presented by Dr. Joseph Mikhael from the Mayo Clinic in Scottsdale, Arizona, who told The Beacon, “This drug was hands down the most promising new agent at ASH for myeloma.”
Dr. Mikhael further explained, “The response rates were impressive, especially in …
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This Monday was the third day of the 2013 American Society of Hematology (ASH) annual meeting, which was held in New Orleans.
More than any other day of the conference, Monday was packed with important myeloma presentations, from 7:00 in the morning until almost 8:00 in the evening.
This ASH update will summarize the oral presentation sessions about treatment-related myeloma studies that were held Monday morning. An ASH update that was published on Wednesday focused on the sessions that were held Monday afternoon and evening.
Monday morning started with three simultaneous …
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At this year’s American Society of Hematology (ASH) meeting, which will be held in early December, more than 100 oral presentations and about 400 poster presentations will summarize research focused on multiple myeloma.
Abstracts for these presentations are now available.
During the next several weeks, The Beacon will publish a series of articles previewing the myeloma-related studies from the ASH meeting that are of particular interest.
Each of the articles will cover abstracts related to a specific topic, such as new treatments under development, current treatments, stem cell transplantation, prognostic factors, and …
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HHV-6 Infection May Be Common After Stem Cell Transplantation – Results of a retrospective Israeli study indicate that human herpesvirus 6 (HHV-6) infection is common in multiple myeloma patients after own (autologous) stem cell transplantation. HHV-6 is a family of two viruses that are present, but inactive, in most adults. If the virus becomes active in an adult, the resulting infection can cause pneumonia, suppression of blood cell production, and inflammation of the brain. The Israeli researchers found that 16 percent of patients in their study developed an HHV-6 infection after stem cell transplantation. The rate of infection was higher in patients who had received initial therapy with Velcade (bortezomib) and dexamethasone (Decadron) (20 percent) compared to those who received thalidomide (Thalomid) and dexamethasone (10 percent). The researchers recommend further studies to determine if Velcade plays a role in the development infection due to the virus. For more information, please see the study in the journal Bone Marrow Research (full text).
Iron Supplementation May Increase Velcade’s Efficacy – Results of a small Italian preclinical study show that iron supplementation may increase the efficacy of Velcade. The Italian researchers found that iron supplementation promoted protein oxidation and increased myeloma cell death. They concluded that modification of the iron status in multiple myeloma patients may be worth considering to improve the efficacy of proteasome inhibitors such as Velcade. For more information, please see the study in Haematologica (full text).
Phase 1 Clinical Trial To Study SAR650984 Plus Revlimid In Previously-Treated Myeloma Patients – The pharmaceutical company Sanofi-Aventis is starting a Phase 1 trial of SAR650984 in combination with Revlimid (lenalidomide) and dexamethasone in relapsed and refractory multiple myeloma patients. Myeloma patients must have received at least two prior therapies to be able to participate in the trial. SAR650984 belongs to the same class of drugs as elotuzumab and daratumumab, called monoclonal antibodies. Monoclonal antibodies work by identifying proteins on the surface of myeloma cells and signaling for the immune system to destroy the cancer cells. For more information, including trial locations, please see the clinical trial description.