The American Society of He­ma­tol­ogy meeting swung into full gear yesterday. The day was full of invited talks and a poster session.

The morn­ing kicked off with an education session in which attendees could learn about sev­er­al myeloma-related topics.

The first pre­sen­ta­tion was by Dr. Ola Landgren from the National Cancer In­sti­tute and National In­sti­tutes of Health in Bethesda, Maryland. Dr. Landgren spoke about mono­clonal gam­mop­athy of undetermined sig­nif­i­cance (MGUS) and smol­der­ing myeloma, precursor dis­eases of mul­ti­ple myeloma.

A study pub­lished by Dr. Landgren last year showed that all mul­ti­ple myeloma patients have …

Onyx Pharmaceuticals announced today that it is delaying for at least six months its application to market carfilzomib, a new treat­ment for multiple myeloma, in the United States.

Prior to today’s announcement, Onyx had expected to submit car­filz­o­mib’s new drug application to the U.S. Food and Drug Administration (FDA) by the end of this year.

Now the com­pany says its application will be submitted “as early as mid-year 2011.”

In its announcement today, Onyx explained that the delay in car­filz­o­mib’s U.S. marketing timeline is due to an FDA request …

Onyx Pharmaceuticals announced yesterday the results of an ongoing Phase 2b trial of single-agent carfilzomib (Kyprolis) for heavily pre-treated re­lapsed and refractory multiple myeloma patients. The over­all response rate after 12 cycles of single-agent car­filz­o­mib treat­ment in this trial was 24 per­cent, and the median duration of response was 7.4 months.

According to Dr. Michael Kauffman, Chief Medical Officer of Onyx Pharmaceuticals, the com­pany’s newly released results dem­onstrate the potential for car­filz­o­mib to significantly improve the outlook for re­lapsed and refractory multiple myeloma patients.

He cited a recent study conducted by …

An ongoing Phase 2 trial of carfilzomib has dem­onstrated that car­filz­o­mib may be effective in treating re­lapsed/refractory multiple myeloma patients, including patients who are resistant to or re­lapsed after Velcade (bor­tez­o­mib) treat­ment. The results were presented by Dr. Ravi Vij of Washington University in St. Louis at the annual American Society of Clinical Oncology (ASCO) meeting in Chicago on June 5.

“Single agent car­filz­o­mib has dem­onstrated significant activity in re­lapsed/refractory myeloma,” said Dr. Vij during his presentation.

Carfilzomib, developed by Onyx Pharmaceuticals, is a new drug cur­rently being in­ves­ti­gated …

Yesterday -- Saturday, June 5 -- was the sec­ond day of the American Society of Clinical Oncology (ASCO) 2010 annual meeting in Chicago.  It was a busy day in terms of re­search posters and pre­sen­ta­tions re­lated to mul­ti­ple myeloma.  As a re­­sult, there is a lot of ground to cover in this up­date.

Almost 40 myeloma-related posters were up for meeting attendees to view during the daytime poster session on "lymphoma and plasma cell disorders."  Among those 40-or-so posters, six con­cerned re­search done by the myeloma team at the Uni­ver­sity of Arkansas for Medical Sciences (UAMS), …

Friday, June 4, was the first day of this year's American Society of Clinical Oncology (ASCO) annual meeting in Chicago. Most of the big multiple myeloma news of the day came out of a poster session in the afternoon.

At "poster sessions," researchers present a poster-sized summary of their research in a small, 2 meter by 1 meter cubicle. Researchers and physicians mill about, taking pictures of the posters with their cell phone cameras or taking notes. Sometimes one or more of the contributing researchers are present to answer questions. More often than …