Advances in the development of multiple myeloma drugs have had a profound impact on the way the disease is treated. Given the efficacy and relative safety of these novel agents, studies are being conducted to determine whether they may be as effective, or possibly even more effective, than an autologous stem cell transplant (ASCT). Two such studies were presented June 6 at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago.

Results from the two studies suggest that ASCT (in which a patient’s own stem cells are transplanted after …

The third day of the American Society of Clinical Oncology (ASCO) 2010 annual meeting in Chicago was tailor-made for morn­ing people interested in mul­ti­ple myeloma.  The key myeloma-related activity on Sunday, June 6 was a morn­ing abstract session start­ing at 9:30 a.m.  Nine abstracts were pre­sented and discussed over the course of three hours.

The first two pre­sen­ta­tions dealt with Velcade (bor­tez­o­mib)-related re­search.

Dr. Antonio Palumbo of the Uni­ver­sity of Turin pre­sented the re­­sults of the first study.  It com­pared two regi­mens for the treat­ment of newly diag­nosed elderly myeloma patients.  The first regi­men in­volved …

Yesterday -- Saturday, June 5 -- was the sec­ond day of the American Society of Clinical Oncology (ASCO) 2010 annual meeting in Chicago.  It was a busy day in terms of re­search posters and pre­sen­ta­tions re­lated to mul­ti­ple myeloma.  As a re­­sult, there is a lot of ground to cover in this up­date.

Almost 40 myeloma-related posters were up for meeting attendees to view during the daytime poster session on "lymphoma and plasma cell disorders."  Among those 40-or-so posters, six con­cerned re­search done by the myeloma team at the Uni­ver­sity of Arkansas for Medical Sciences (UAMS), …

A recent study conducted in Scandinavia shows that the combination treatment of melphalan (Alkeran), prednisone and thalidomide (Thalomid), referred to as MPT, has significant anti-myeloma effects when compared to melphalan and prednisone treatment, referred to as MP, in elderly patients.  However, MPT treatment did not increase progression-free and overall survival or improve quality of life compared to MP treatment.

Studies examining the effect of adding thalidomide to MP treatment have previously been conducted in several European countries.  All studies found that the addition of thalidomide increased anti-myeloma effects. However, …

The combination therapy of Velcade (bortezomib), melphalan (Alkeran), and prednisone, commonly referred to as VMP, extends overall survival in newly diagnosed multiple myeloma patients, compared to melphalan-prednisone (MP) therapy, even after prolonged follow-up and extensive subsequent therapy. Researchers also found that VMP did not increase resistance to subsequent therapy.

The Phase 3 clinical trial, known as VISTA, had shown that VMP therapy improved outcomes in newly diagnosed multiple myeloma patients compared to MP therapy. In particular, patients on VMP showed better response and longer overall survival than patients on …

The combination regimen of Revlimid (lenalidomide), melphalan (Alkeran), prednisone, and thalidomide (Thalomid), abbreviated RMPT, is an active and safe therapy for multiple myeloma patients who have relapsed or who are resistant (refractory) to previous myeloma treatment. The findings were published recently in the journal Leukemia.

Although melphalan-prednisone (MP) combination has been a standard therapy in multiple myeloma for the last thirty years, the introduction of novel agents, such as Revlimid, thalidomide and Velcade, has significantly improved response rates and extended remission in patients with refractory and relapsed …

An expert panel of European hematologists has published guidelines for treating newly diagnosed multiple myeloma patients with thalidomide (Thalomid) in addition to melphalan (Alkeran) and prednisone. The guidelines are intended to help physicians and patients manage the side effects commonly associated with thalidomide treatment.

For the last four decades, the standard front-line therapy for newly diagnosed myeloma patients who are ineligible for stem cell transplantation has been a combination regimen of melphalan and prednisone (MP). However, the results from five Phase 3 clinical trials have indicated that the addition …