Articles tagged with: Panobinostat

News»

[ by | Jun 8, 2011 6:13 pm | Comments Off ]
ASCO 2011 Multiple Myeloma Update – Day Four

Monday was the fourth day of the American Society of Clinical Oncology (ASCO 2011) annual meeting in Chicago.  Although the meeting concluded yes­ter­day, Monday was the last day of the meeting that con­tained any myeloma-relevant ma­teri­al.

The morn­ing started with a session recapping highlights of the meeting from Sunday.  Dr. Ivan Borello from the Johns Hopkins Uni­ver­sity School of Medicine was invited to give a 15-minute pre­sen­ta­tion recapping the myeloma highlights (see Part 1 and Part 2 of The Beacon’s Day Three up­date for more in­­for­ma­tion).

The rest of the …

Read the full story »

News»

[ by and | May 25, 2011 6:26 pm | One Comment ]
Myeloma Research To Be Presented At The American Society of Clinical Oncology’s 47th Annual Meeting (ASCO 2011)

The 47th annual meeting of the American Society of Clinical Oncology (ASCO) will take place Friday, June 3, through Tuesday, June 7, in Chicago.

More than 30,000 clin­i­cal spe­cialists from all over the world are ex­pected to attend the five-day meeting to discuss the cur­rent re­search in cancer treat­ment and care. This year’s meeting will primarily focus on the theme of “Patients, Pathways, Progress.”

The meeting will in­clude many pre­sen­ta­tions and seminars focused spe­cif­i­cally on mul­ti­ple myeloma. The ASCO website cur­rently lists over 40 myeloma-based abstracts.

The Myeloma Beacon will be …

Read the full story »

News»

[ by | May 9, 2011 4:18 pm | One Comment ]
IMW 2011 Multiple Myeloma Update – Day Three Part 1

Thursday was the third day of the Inter­na­tional Myeloma Workshop (IMW) in Paris.  There were pre­sen­ta­tions from early morn­ing through the evening.

Some of the highlights from the first part of Day 3 of the conference are summarized in this article.  Highlights from the sec­ond part of the day are summarized in a separate article (see re­lated Beacon news).

Treating Older, Newly Diagnosed Myeloma Patients

The first session of the morn­ing was about treating newly diag­nosed mul­ti­ple myeloma patients over the age of 65 years, spe­cif­i­cally those who are in­eli­gible for …

Read the full story »

News, Opinion»

[ by | Apr 15, 2011 10:04 am | 17 Comments ]
Promising New Drugs For Myeloma: Will The Future Come Soon Enough?

Each year at the Annual Meeting of the American Society of He­ma­tol­ogy we hear about dozens of new drugs that are able to annihilate mul­ti­ple myeloma cells in the test tube and in animal models. Unfortunately, at the same meeting, we also sit through pre­sen­ta­tions and walk by posters of drugs that looked hot in the laboratory but then fail to work when given to real patients with myeloma.

This is not new. It has been the story with myeloma for ages. The myeloma cells are smart and are seemingly able to …

Read the full story »

News»

[ by | Feb 28, 2011 11:40 am | 10 Comments ]
Thought Leader Perspective: Dr. Kenneth Anderson On The Future Of Myeloma Treatment

Dr. Kenneth Anderson, a world-renowned myeloma spe­cialist, physician and re­searcher at Dana-Farber Cancer In­sti­tute, and Kraft Family Pro­fessor at Harvard Medical School, spoke with The Myeloma Beacon about his ap­proach to treating mul­ti­ple myeloma patients.

This article is the sec­ond part of a two-part series based on The Myeloma Beacon’s interview with Dr. Anderson.  It will cover Dr. Anderson’s thoughts on where myeloma treat­ment is headed in the com­ing years.  For more in­­for­ma­tion on Dr. Anderson’s cur­rent ap­proach to treating mul­ti­ple myeloma, please see part one of this series.

Emerging Therapies …

Read the full story »

NewsFlash »

[ by | Dec 10, 2010 3:53 pm | Comments Off ]

Myeloma Expert Dr. Philip McCarthy To Field Questions At The Beacon Forums Next Week – During the week of December 13 through 17, multiple myeloma patients will have the opportunity to get expert answers to their myeloma-related questions: Myeloma expert Dr. Philip McCarthy from the Roswell Park Cancer Institute in Buffalo, NY, will answer medical questions posted to the Beacon’s multiple myeloma forums throughout the week. Readers are encouraged to start posting their questions in the forums.

BT-062 Is Safe In Relapsed/Refractory Multiple Myeloma (ASH 2010) – The investigational drug BT-062, which is being developed by the German company Biotest AG, is safe in relapsed/refractory multiple myeloma patients, according to the Phase 1 trial results presented at the 2010 Meeting of the American Society of Hematology (ASH). Researchers tested seven different dose levels (10 mg/m² to 200 mg/m²). Researchers observed severe skin- and mucous membrane-related side effects at the highest dose level. They therefore determined the maximum tolerated dose to be 160 mg/m². A sufficient amount of anti-myeloma activity was observed for this drug to continue to Phase 1/2 testing, which puts more emphasis on the efficacy of the drug. For more information, please see abstract 3060 on the ASH annual meeting website.

ARRY-520 Shows Single-Agent Activity in Relapsed/Refractory Myeloma (ASH 2010) – Phase 1 clinical trial results presented at ASH earlier this week showed that the experimental drug ARRY-520 (filanesib) from Array BioPharma has anti-myeloma effects as a single agent. Four of 30 relapsed/refractory myeloma patients enrolled in the study responded to treatment. ARRY-520 was administered intravenously at different doses (1 mg/m2 to 2.25 mg/m2) on days 1 and 2 of a 14-day cycle with or without growth factors.  The maximum tolerated dose was 1.25 mg/m2 ARRY-520, but the dose could be increased with the addition of growth factors. The most commonly reported side effect was low white blood cell counts. Inflammation of the digestive tract mucus membrane was observed at higher dose levels.  The maximum tolerated dose in combination with growth factors, which is still being investigated, will be used in the Phase 2 trials that Array BioPharma plans to initiate soon. For more information, please see abstract 1959 on the ASH meeting website and the Array BioPharma press release.

Panobinostat Combination Shows Potential For Relapsed/Refractory Multiple Myeloma (ASH 2010) – According to Phase 1 trial results presented at ASH, the oral experimental cancer drug panobinostat (Farydak, LBH589) from Novartis showed promising results in combination with melphalan (Alkeran), prednisone, and thalidomide (Thalomid). Of the 24 relapsed/refractory myeloma patients enrolled in the study, 50 percent responded to the treatment, with 17 percent achieving a very good partial response. However, the initial dose of 15 mg of panobinostat was associated with severe side effects (low white blood cell counts in 69 percent of patients and low platelet counts in 46 percent).  Therefore, researchers decided to lower the dose to 10 mg. The rate of low platelet counts decreased, but the rate of low white blood cell counts remained high. The researchers concluded that different dosing schedules need to be investigated to further decrease the rate of blood-related side effects. For more information, please see abstract 3019 on the ASH meeting website.

News»

[ by | Jun 23, 2010 5:57 pm | Comments Off ]
Panobinostat Combinations Show Therapeutic Benefit In Advanced Multiple Myeloma (ASCO 2010)

Results of two Phase 1b clinical trials suggest that panobinostat (Farydak) in combination with Velcade (bortezomib) or Revlimid (lenalidomide) and dexamethasone (Decadron) is effective and well-tolerated in patients who are resistant (refractory) to previous multiple myeloma treatment. The findings were presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago in early June.

“There are novel therapies that have improved the outcome, literally doubled the survival, of patients with myeloma. Despite these incredible advances, inevitably most patients relapse, and so …

Read the full story »