Articles tagged with: Panobinostat
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Monday was the fourth day of the American Society of Clinical Oncology (ASCO 2011) annual meeting in Chicago. Although the meeting concluded yesterday, Monday was the last day of the meeting that contained any myeloma-relevant material.
The morning started with a session recapping highlights of the meeting from Sunday. Dr. Ivan Borello from the Johns Hopkins University School of Medicine was invited to give a 15-minute presentation recapping the myeloma highlights (see Part 1 and Part 2 of The Beacon’s Day Three update for more information).
The rest of the …
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The 47th annual meeting of the American Society of Clinical Oncology (ASCO) will take place Friday, June 3, through Tuesday, June 7, in Chicago.
More than 30,000 clinical specialists from all over the world are expected to attend the five-day meeting to discuss the current research in cancer treatment and care. This year’s meeting will primarily focus on the theme of “Patients, Pathways, Progress.”
The meeting will include many presentations and seminars focused specifically on multiple myeloma. The ASCO website currently lists over 40 myeloma-based abstracts.
The Myeloma Beacon will be …
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Thursday was the third day of the International Myeloma Workshop (IMW) in Paris. There were presentations from early morning through the evening.
Some of the highlights from the first part of Day 3 of the conference are summarized in this article. Highlights from the second part of the day are summarized in a separate article (see related Beacon news).
Treating Older, Newly Diagnosed Myeloma Patients
The first session of the morning was about treating newly diagnosed multiple myeloma patients over the age of 65 years, specifically those who are ineligible for …
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Each year at the Annual Meeting of the American Society of Hematology we hear about dozens of new drugs that are able to annihilate multiple myeloma cells in the test tube and in animal models. Unfortunately, at the same meeting, we also sit through presentations and walk by posters of drugs that looked hot in the laboratory but then fail to work when given to real patients with myeloma.
This is not new. It has been the story with myeloma for ages. The myeloma cells are smart and are seemingly able to …
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Dr. Kenneth Anderson, a world-renowned myeloma specialist, physician and researcher at Dana-Farber Cancer Institute, and Kraft Family Professor at Harvard Medical School, spoke with The Myeloma Beacon about his approach to treating multiple myeloma patients.
This article is the second part of a two-part series based on The Myeloma Beacon’s interview with Dr. Anderson. It will cover Dr. Anderson’s thoughts on where myeloma treatment is headed in the coming years. For more information on Dr. Anderson’s current approach to treating multiple myeloma, please see part one of this series.
Emerging Therapies …
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Myeloma Expert Dr. Philip McCarthy To Field Questions At The Beacon Forums Next Week – During the week of December 13 through 17, multiple myeloma patients will have the opportunity to get expert answers to their myeloma-related questions: Myeloma expert Dr. Philip McCarthy from the Roswell Park Cancer Institute in Buffalo, NY, will answer medical questions posted to the Beacon’s multiple myeloma forums throughout the week. Readers are encouraged to start posting their questions in the forums.
BT-062 Is Safe In Relapsed/Refractory Multiple Myeloma (ASH 2010) – The investigational drug BT-062, which is being developed by the German company Biotest AG, is safe in relapsed/refractory multiple myeloma patients, according to the Phase 1 trial results presented at the 2010 Meeting of the American Society of Hematology (ASH). Researchers tested seven different dose levels (10 mg/m² to 200 mg/m²). Researchers observed severe skin- and mucous membrane-related side effects at the highest dose level. They therefore determined the maximum tolerated dose to be 160 mg/m². A sufficient amount of anti-myeloma activity was observed for this drug to continue to Phase 1/2 testing, which puts more emphasis on the efficacy of the drug. For more information, please see abstract 3060 on the ASH annual meeting website.
ARRY-520 Shows Single-Agent Activity in Relapsed/Refractory Myeloma (ASH 2010) – Phase 1 clinical trial results presented at ASH earlier this week showed that the experimental drug ARRY-520 (filanesib) from Array BioPharma has anti-myeloma effects as a single agent. Four of 30 relapsed/refractory myeloma patients enrolled in the study responded to treatment. ARRY-520 was administered intravenously at different doses (1 mg/m2 to 2.25 mg/m2) on days 1 and 2 of a 14-day cycle with or without growth factors. The maximum tolerated dose was 1.25 mg/m2 ARRY-520, but the dose could be increased with the addition of growth factors. The most commonly reported side effect was low white blood cell counts. Inflammation of the digestive tract mucus membrane was observed at higher dose levels. The maximum tolerated dose in combination with growth factors, which is still being investigated, will be used in the Phase 2 trials that Array BioPharma plans to initiate soon. For more information, please see abstract 1959 on the ASH meeting website and the Array BioPharma press release.
Panobinostat Combination Shows Potential For Relapsed/Refractory Multiple Myeloma (ASH 2010) – According to Phase 1 trial results presented at ASH, the oral experimental cancer drug panobinostat (Farydak, LBH589) from Novartis showed promising results in combination with melphalan (Alkeran), prednisone, and thalidomide (Thalomid). Of the 24 relapsed/refractory myeloma patients enrolled in the study, 50 percent responded to the treatment, with 17 percent achieving a very good partial response. However, the initial dose of 15 mg of panobinostat was associated with severe side effects (low white blood cell counts in 69 percent of patients and low platelet counts in 46 percent). Therefore, researchers decided to lower the dose to 10 mg. The rate of low platelet counts decreased, but the rate of low white blood cell counts remained high. The researchers concluded that different dosing schedules need to be investigated to further decrease the rate of blood-related side effects. For more information, please see abstract 3019 on the ASH meeting website.
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Results of two Phase 1b clinical trials suggest that panobinostat (Farydak) in combination with Velcade (bortezomib) or Revlimid (lenalidomide) and dexamethasone (Decadron) is effective and well-tolerated in patients who are resistant (refractory) to previous multiple myeloma treatment. The findings were presented at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago in early June.
“There are novel therapies that have improved the outcome, literally doubled the survival, of patients with myeloma. Despite these incredible advances, inevitably most patients relapse, and so …