Articles tagged with: Neupogen

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[ by | Mar 25, 2016 11:50 am | Comments Off ]
Myeloma Morning: Extramedullary Disease Case Reports, And Zarxio vs. Neupogen

Good morning, myeloma world.

We have got quite an eclectic mix of myeloma-related research to report on today, ranging from a couple of lengthy review articles to a short case report.

Speaking of case reports, there are several of them, and we'll start with an unusual one. It's from a group of physicians at a hospital in Milan, Italy. They report on a patient with light chain monoclonal gammopathy who tested positive – incorrectly – on a standard test used to determine if someone regularly drinks a lot of alcohol (abstract). …

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[ by | Aug 12, 2013 5:28 pm | 3 Comments ]

Velcade Receives Additional Approvals In Europe – The approved uses of Velcade (bor­tez­o­mib) for mul­ti­ple myeloma patients were recently ex­panded in the Euro­pean Union. These addi­tional approved uses in­clude treat­ment of newly diag­nosed trans­plant-eligible myeloma patients with Velcade plus dexa­meth­a­sone (Decadron) or Velcade plus thalidomide (Thalomid) and dexa­meth­a­sone, as well as retreatment of re­lapsed myeloma patients with Velcade for those who responded to prior Velcade ther­apy.  Previously, Velcade was approved in com­bi­na­tion with melphalan (Alkeran) and prednisone for the treat­ment of newly diag­nosed myeloma patients who are in­eli­gible for stem cell trans­plan­ta­tion, or as a single agent for the treat­ment of re­lapsed myeloma patients with one prior ther­apy who have had a trans­plant or are in­eli­gible for a trans­plant.   For more in­for­ma­tion, please see the August 8 and June 28 Johnson & Johnson press releases about the new ap­­prov­als for newly diag­nosed and re­lapsed myeloma patients.

Pilot Clinical Trial To Test Whether Anti-Depressant Desipramine Assists With Stem Cell Mobilization – Researchers from the Albert Einstein College of Medicine in New York City have launched a clin­i­cal trial that will de­ter­mine how well the antidepressant desipramine (Norpramin, Pertofrane) in com­bi­na­tion with Neupogen (filgrastim), which is a type of granulocyte colony-stimulating factor (G-CSF), works to mobilize stem cells in mul­ti­ple myeloma patients undergoing stem cell trans­plan­ta­tion. A pre­vi­ous study in mice showed that desipramine plus G-CSF mobilized more stem cells than G-CSF alone.  For more in­for­ma­tion about the study or how to en­roll, see the clinical trial description.

Clinical Trial To Study Modified Version Of Melphalan Plus Dexa­meth­a­sone For Re­lapsed / Re­frac­tory Myeloma – A new Phase 1/2 clin­i­cal trial is testing the ef­fi­cacy and safety of a modified version of mel­pha­lan in com­bi­na­tion with dexa­meth­a­sone for re­lapsed and re­frac­tory myeloma patients. The modified version of mel­phalan, known as mel­phalan-flufenamide or melflufen, is being devel­oped by the Swedish pharma­ceu­ti­cal com­pany Oncopeptides and consists of melphalan bound to flufenamide.  The drug only be­comes active once it enters a cell and mel­phalan is released from flufenamide.  Cancer cells more efficiently ac­ti­vate the drug, in­creas­ing the con­cen­tra­tion of mel­phalan in cancer cells com­pared to healthy cells. The study is sponsored by Oncopeptides and is being conducted in the United States and Europe. For more in­for­ma­tion about the study or how to en­roll, see the clinical trial description and related Oncopeptides press release.

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[ by | May 3, 2013 7:33 pm | One Comment ]
Study Questions Conventional Wisdom On Revlimid And Stem Cell Collection

A recent retrospective study finds that initial treatment with Revlimid may not prevent myeloma patients from collecting enough stem cells for transplantation.

Many of the study's results confirm the findings of previous research, which has shown that Revlimid (lenalidomide) reduces a patient's ability to mobilize stem cells for stem cell collection (see related Beacon news).

However, only 2 percent of the patients in the new study were unable to mobilize enough stem cells for at least a single transplant, and this low overall rate of mobilization failure was the same in patients who …

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[ by | Apr 20, 2012 11:55 am | 9 Comments ]
Mozobil May Help Revlimid-Treated Myeloma Patients Collect Enough Stem Cells For Transplantation

A recent study suggests that Mozobil helps multiple myeloma patients with prior exposure to Revlimid collect enough stem cells for transplantation.

The study investigators conclude that stem cell mobilization with the aid of a growth factor plus Mozobil (plerixafor) is an effective upfront approach for multiple myeloma patients who plan to undergo a transplant, regardless of previous Revlimid (lenalidomide) exposure.

“With growth factor and preemptive Mozobil, virtually all patients with multiple myeloma can have successful stem cell collection,” said Dr. Luciano Jose Costa of the Medical University of South Carolina, and …

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[ by | Oct 12, 2011 2:48 pm | 2 Comments ]
Neupogen And Neulasta Show Comparable Activity In Multiple Myeloma Patients After Stem Cell Transplantation

Results of a recent Italian study show that Neupogen and Neulasta are comparable in efficacy and safety for the prevention and treatment of low white blood cell counts in multiple myeloma patients receiving outpatient stem cell transplants.

However, patients who were treated with Neulasta only received one injection after the transplant, which according to the study authors may be more convenient for the patients.

“In our experience, the possibility of a single [injection] is more comfortable for patients, mainly in an outpatient regimen,” said Dr. Felicetto Ferrara of the Cardarelli Hospital in …

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[ by | Apr 8, 2011 1:24 pm | 3 Comments ]
Mozobil May Help Myeloma Patients Collect Enough Stem Cells For A Second Transplant

Results of a recent Polish study show that the drug Mozobil may help multiple myeloma patients who previously had a stem cell transplant collect enough stem cells for a second transplant.

However, the results also showed that previously transplanted patients collected fewer stem cells than patients who had not received a stem cell transplant before.

According to the study authors, these results showed for the first time that Mozobil (plerixafor) is highly effective for previously transplanted myeloma patients.

Autologous stem cell transplantation, a common treatment option for younger, newly diagnosed myeloma …

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[ by | Nov 9, 2010 2:36 pm | Comments Off ]
Growth Factor May Not Be Required Following Stem Cell Transplantation In Multiple Myeloma Patients

According to a recent study, omitting growth factor administration following stem cell transplantation results in fewer side effects and less and shorter hospitalization for multiple myeloma patients compared to those who do receive growth factors. In addition, the study authors found that there was little difference between the two groups in the repopulation of white blood cells following transplantation.

According to Dr. Morie Gertz, myeloma expert at the Mayo Clinic in Rochester, Minnesota and lead author of the study, the difference in the repopulation of white blood cells was not clinically significant. …

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