A new retrospective study by Emory University researchers may stir de­bate about the best way to treat high-risk myeloma patients.

The researchers investigated treating high-risk myeloma patients for up to three years with a combination of Revlimid, Velcade, and dex­a­meth­a­sone.

The extended three-drug ther­a­py, which the authors describe as a com­bined con­sol­i­da­tion/​main­te­nance regimen, was initiated after the pa­tients had re­ceived a stem cell transplant.  The patients' transplants were car­ried out soon after completion of the first (induction) treat­ment reg­i­men fol­low­ing diagnosis.

Some, but not all, of the patients also received the Revlimid-Velcade-dexamethasone …

Results from a recent retrospective study conducted in France indicate that long-term treat­ment with Revlimid plus dex­a­meth­a­sone is effective in delaying dis­ease progression in relapsed multiple myeloma patients.

Among patients treated with Revlimid (lenalidomide) plus dex­a­meth­a­sone (Dec­a­dron) for at least two years, almost all (96 percent) responded to treat­ment, with 74 percent achieving at least a very good partial re­sponse.

Patients who received treat­ment for at least three years were significantly more likely to have not yet progressed 37 months after beginning treat­ment (91 percent), compared to patients who …

Researchers from the Moffitt Cancer Center recently published results from a Phase 2 clinical trial that investigated the combination of Revlimid plus Doxil and low-dose dexa­metha­sone as initial therapy for patients with newly diag­nosed multiple myeloma.

Although the results show an overall re­sponse rate of 77 per­cent, a medi­an progression-free survival time of 28 months, and a one-year overall survival rate of 98 per­cent for the Revlimid (lenalidomide), Doxil (doxo­ru­bi­cin liposomal), and dexa­metha­sone (Decadron) combination, the re­search­ers indicate that this combination is not an improvement on …

Results from a recent Phase 2 trial indicate that the com­bi­na­tion of Kyprolis, Revlimid, and dexa­meth­a­sone is effective in re­lapsed multi­ple myeloma patients.

Specifically, the results show that 77 per­cent of patients responded to the treat­ment. The investigators point out the responses seen in the trial were rapid (median time to response was one month) and robust (medi­an duration of response was 22 months).

According to the investigators, the results are particularly encouraging because one-quarter of the patients were refractory (resistant) to Velcade (bor­tez­o­mib) and almost half were refractory to …

Final results from a Phase 3 study show that Pomalyst in combination with low-dose dexamethasone is effective for relapsed and refractory multiple myeloma patients not responding to treatment with Revlimid and Velcade.

Specifically, the results show that patients receiving Pomalyst (pomalidomide, Imnovid) in combination with low-dose dexamethasone (Decadron) had higher response rates and longer progression-free and overall survival than patients who received high-dose dexamethasone alone.

High-dose dexamethasone was chosen as the comparator in this study because, according to the study investigators, it was a common rescue treatment for …

Final results from a recent Phase 2 clinical trial continue to indicate that panobinostat in combination with Velcade and dexamethasone is effective for heavily pretreated multiple myeloma.

In the study, known as “PANORAMA 2,” patients who had previously relapsed and were no longer responsive to Velcade (bortezomib)-based treatment received panobinostat in combination with Velcade and dexamethasone (Decadron).

The results show that one-third (35 percent) of the patients responded to the treatment, and the median progression-free survival was 5.4 months.

In comparison, myeloma experts found during a prior review of the …