Results from three clinical trials involving the inves­ti­ga­tional drug filanesib were presented at the American Society of Hematology (ASH) annual meeting earlier this month.

The trials evaluated the efficacy of filanesib (ARRY-520) alone and in com­bi­na­tion with other agents as potential treat­ments for re­lapsed and refractory multiple myeloma patients.

Overall, the trial results presented at ASH con­firm existing impressions of filanesib as a promising potential myeloma ther­apy.

Results of a Phase 2 trial of filanesib with or without low-dose dex­a­meth­a­sone (Decadron) show that 16 per­cent of patients who …

ARRY-520 is one of several potential new anti-myeloma agents that was highlighted at the American Society of Hematology (ASH) annual meeting earlier this week.

Initial results from two clinical trials show promise for ARRY-520 (filanesib), alone or in com­bi­na­tion with other myeloma drugs, as a thera­peutic option for heavily pretreated multiple myeloma patients.

“ARRY-520 shows promising activity in com­bi­na­tion with dexa­meth­a­sone in heavily pretreated myeloma patients,” said Dr. Jatin Shah, from the MD Anderson Cancer Center in Houston and lead investigator of both studies.

Based on their findings, the study investigators …