Myeloma Patients May Be At Higher Risk For Restless Legs Syndrome – Results from a recent Turkish study show that restless legs syndrome occurs more frequently in multiple myeloma patients than in healthy adults. Restless legs syndrome is a condition characterized by uncomfortable sensations in the legs and an uncontrollable urge to move them, often leading to sleep deprivation. In this study, 18 percent of myeloma patients had restless legs syndrome, compared to 3 percent in the healthy population. Multiple myeloma patients with restless legs syndrome had higher levels of depression and anxiety and a poorer quality of life compared to those without the condition. The researchers conclude that targeting restless legs syndrome may improve overall health outcomes in myeloma patients. For more information, please see the study in the Journal of Clinical Medicine Research (abstract).

Ibrutinib Enhances Anti-Myeloma Activity Of Velcade And Revlimid – Results from a recent preclinical study show that ibrutinib (PCI-32765) may enhance the activity of Velcade (bortezomib) plus Revlimid (lenalidomide). Ibrutinib, which is being developed by biotech company Pharmacyclics in cooperation with Johnson & Johnson, blocks a protein called Bruton’s tyrosine kinase (Btk). Btk is found in antibody-producing cells and in cells that break down bone tissue. Ibrutinib is currently being investigated as a potential treatment for a number of different blood cancers, including multiple myeloma. The study researchers believe their data warrants further investigation of ibrutinib as part of a combination drug therapy for multiple myeloma. For more information, please see the study in Cellular Signalling (abstract).

Phase 1/2 Clinical Trial To Study PRLX 93936 In Relapsed And Refractory Multiple Myeloma Patients – Prolexys Pharmaceuticals is starting a Phase 1/2 clinical trial of PRLX 93936 in relapsed and refractory myeloma patients.  PRLX 93936 is a small-molecule anti-cancer treatment that targets the RAS protein. Specifically, researchers are seeking to determine patient response to and the maximum tolerated dose of PRLX 93936. Patients must have received two or more prior treatment regimens, including a proteasome inhibitor (such as Velcade) and/or an immunomodulatory agent (such as Revlimid) to be eligible for the study. For more information, please see the clinical trial description.