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What is hypogammaglobulinemia?

by sull51 on Tue Feb 16, 2016 10:45 pm

I have been in complete remission for about 6 months. However, my most recent serum protein electrophoresis (SPEP) test shows a new condition:

Hypogammaglobulinemia is present. No abnormal restricted bands detected.

What is hypogammaglobulinemia?

Is it something I should be worried about?

sull51

Re: What is hypogammaglobulinemia?

by Multibilly on Wed Feb 17, 2016 10:00 am

Hi Sull51,

First off, I'm not a doc, so please check with yours.

Hypo­gamma­globu­li­nemia is the suppression of one or more of one's normal immuno­globu­lin (IgG, IgA, IgM, etc) levels. It sometimes occurs in patients with multiple myeloma. Without normal, func­tioning levels of immunoglobulins, one tends to be more prone to infections.

Depending on the degree of hypo­gamma­globulinemia and how often you might be becoming ill of suffering side effects of having an impaired immune system, a doctor may or not decide to treat it. The most common treatment for hypo­gamma­globulinemia is to administer IVIG (intravenous gamma­globulin).

Multibilly
Name: Multibilly
Who do you know with myeloma?: Me
When were you/they diagnosed?: Smoldering, Nov, 2012

Re: What is hypogammaglobulinemia?

by Janet1520 on Thu Feb 18, 2016 12:03 am

Sull51,

I had that very same thing show up on my lab tests. Been that way over a year. Multibilly is correct, it's from suppressed immunoglobulins. My IgG is 335, IgA is 27, and IgM is 12. Oddly enough, I'm never sick. I suspect, if you started getting sick a lot, your doctor would consider IVIG therapy. But if you feel fine, no worries. Just practice good hygiene, try to avoid door knobs, and wear a mask on planes.

Janet1520


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