Hello everyone,
I’m very confused about all these tests, so I would like to ask a question.
Urine Protein Electrophoresis results in three different occasions with months in between shows.
ABNORMAL PROTEIN BAND 1 mg/dl see note
No M-spike detected
The protein fractions are too small to quantitate.
Serum Protein Electrophoresis shows a faint band in the beta region twice and in the 3rd round of tests in another lab two faint bands in the gamma region. High kappa and high lambda with normal ratio (1.8).
BETA 2 MICROGLOBULIN SERUM 2.30 mg/L and ALBUMIN 3.5 g/dL.
(I gave more details in my other posts).
What is ABNORMAL PROTEIN BAND 1?
Thank you so much for your help and all the best for you all.
Moderator's Note: We have added a link to Betsy50's earlier postings in the posting above. The link was not initially present when the posting was first made, which is the reason for some of the discussion below about making it easy to locate those postings.
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Re: What is "Abnormal Protein Band 1"?
Hello Betsy,
I think the lab results may be saying ABNORMAL PROTEIN BAND, 1mg/dL
Have you asked your doctor?
I think the lab results may be saying ABNORMAL PROTEIN BAND, 1mg/dL
Have you asked your doctor?
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dnalex - Name: Alex N.
- Who do you know with myeloma?: mother
- When were you/they diagnosed?: 2007
- Age at diagnosis: 56
Re: What is "Abnormal Protein Band 1"?
Actually, I think Betsy got it right. But , it beats me what the difference is between the three Abnormal Protein Bands in a UPEP report. See:
http://www.questdiagnostics.com/testcenter/BUOrderInfo.action?tc=10263&labCode=TMP
50060000 ABNORMAL PROTEIN BAND 1 42482-0 Protein.monoclonal
50060001 ABNORMAL PROTEIN BAND 2 42482-0 Protein.monoclonal
50060002 ABNORMAL PROTEIN BAND 3 42482-0 Protein.monoclona
http://www.questdiagnostics.com/testcenter/BUOrderInfo.action?tc=10263&labCode=TMP
50060000 ABNORMAL PROTEIN BAND 1 42482-0 Protein.monoclonal
50060001 ABNORMAL PROTEIN BAND 2 42482-0 Protein.monoclonal
50060002 ABNORMAL PROTEIN BAND 3 42482-0 Protein.monoclona
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: What is "Abnormal Protein Band 1"?
Thanks Alex and Multibilly for your reply,
No I did not ask my doctor that question, because I didn’t have the chance to do it. The doctor was talking in general terms and just said that I have a lot going on with my health so I don’t need any thing else to worry about, that when multiple myeloma is active generally one of the immunoglobulin goes very high and the other goes down and that is not my case because
IgA - 447 mg/dl,
IgG - 1224 mg/dl,
IgM -81 mg/dl,
IgE 212 kU/L (High)
and my hemoglobin was 12.2 and calcium 9.9 mg/dl still OK doctor said.
So I’m very frustrated because I still don’t have a stray diagnosis and I feel that I was treated like a little child. I was stunned, I left the office and I did not ask any of the questions that I needed to ask. Could you believe it?
I don’t know if somebody else experienced something like that before and can understand what happen to me? Because I still don’t know why that is happening to me lately because it is not the first time (I am so mad at myself!!!).
Then the question remain: Do I have a monoclonal immunoglobulin?
No I did not ask my doctor that question, because I didn’t have the chance to do it. The doctor was talking in general terms and just said that I have a lot going on with my health so I don’t need any thing else to worry about, that when multiple myeloma is active generally one of the immunoglobulin goes very high and the other goes down and that is not my case because
IgA - 447 mg/dl,
IgG - 1224 mg/dl,
IgM -81 mg/dl,
IgE 212 kU/L (High)
and my hemoglobin was 12.2 and calcium 9.9 mg/dl still OK doctor said.
So I’m very frustrated because I still don’t have a stray diagnosis and I feel that I was treated like a little child. I was stunned, I left the office and I did not ask any of the questions that I needed to ask. Could you believe it?
I don’t know if somebody else experienced something like that before and can understand what happen to me? Because I still don’t know why that is happening to me lately because it is not the first time (I am so mad at myself!!!).
Then the question remain: Do I have a monoclonal immunoglobulin?
Re: What is "Abnormal Protein Band 1"?
Are you seeing a multiple myeloma specialist? It would be good to have another person come with you when you see your doctor. They can help remember questions (write them down beforehand in a notebook just for this purpose), even ask questions that you forget or aren't clear about.
My husband was diagnosed with multiple myeloma in June, 2014. We are seeing an oncologist at a cancer facility and the doctors deal with multiple myeloma along with other cancers. If you are not getting satisfaction from the doctor, get another opinion. It's your body and your life! It is very overwhelming to deal with any kind of cancer.
My husband was diagnosed with multiple myeloma in June, 2014. We are seeing an oncologist at a cancer facility and the doctors deal with multiple myeloma along with other cancers. If you are not getting satisfaction from the doctor, get another opinion. It's your body and your life! It is very overwhelming to deal with any kind of cancer.
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JoGlo - Who do you know with myeloma?: husband
- When were you/they diagnosed?: June, 2014
- Age at diagnosis: 72
Re: What is "Abnormal Protein Band 1"?
Betsy,
Don't beat yourself up for not asking the basic questions or not recalling everything. I still forget to ask key questions, especially when a curve is thrown at me during an appointment. So I would take JoGlo's advice and write down all your questions beforehand and also record the meeting and/or bring a friend along to listen with a second pair of ears ... and seek out a specialist.
But what caused the doc to look for multiple myeloma in the first place?
While what the doctor describes as far as multiple myeloma being active if one of the immunoglobulins goes very high and another (or others) goes down can certainly happen (this is known as immunoparesis), I don't think I would call that a hallmark trait of multiple myeloma.
It's also interesting that both your kappa and lambda are high (how elevated are they?), and your IgA is slightly elevated (does it show as being out of range on your lab report?). It's useful if you also list the normal ranges for any lab values since they can vary from lab to lab (there's unfortunately not just one golden standard for what these values should be).
Also, while you say you listed your results in other posts, one can't find those posts given the way you have your profile set up on the Beacon (if you look at your posts, you will notice that you can't click on your name to see your other posts). You might want to just list all your results on one simple reply to this post.
Good luck to you and I hope this helps a little bit.
Don't beat yourself up for not asking the basic questions or not recalling everything. I still forget to ask key questions, especially when a curve is thrown at me during an appointment. So I would take JoGlo's advice and write down all your questions beforehand and also record the meeting and/or bring a friend along to listen with a second pair of ears ... and seek out a specialist.
But what caused the doc to look for multiple myeloma in the first place?
While what the doctor describes as far as multiple myeloma being active if one of the immunoglobulins goes very high and another (or others) goes down can certainly happen (this is known as immunoparesis), I don't think I would call that a hallmark trait of multiple myeloma.
It's also interesting that both your kappa and lambda are high (how elevated are they?), and your IgA is slightly elevated (does it show as being out of range on your lab report?). It's useful if you also list the normal ranges for any lab values since they can vary from lab to lab (there's unfortunately not just one golden standard for what these values should be).
Also, while you say you listed your results in other posts, one can't find those posts given the way you have your profile set up on the Beacon (if you look at your posts, you will notice that you can't click on your name to see your other posts). You might want to just list all your results on one simple reply to this post.
Good luck to you and I hope this helps a little bit.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: What is "Abnormal Protein Band 1"?
Thanks JoGlo and Multibilly for your advices, they are excellent suggestions so I will follow them.
JoGlo, I’m sorry for your husband diagnosis, but I’m glad that you are getting good care with a myeloma specialist in a cancer facility and wish all the best.
No, I’m not seeing a multiple myeloma specialist, I go to a clinic so it is a little big complicated to get refer out of the circle that they have, so I’m seeing an oncologist / hematologist that works there.
Once again, many thanks for your input Multibilly and all your help through out this journey with all your knowledge.
When you said “I don't think I would call that a hallmark trait of multiple myeloma” I agree with you one hundred percent. That is one of the reasons It was so shocking, and it helps a lot to see that you understand exactly what happened that day. For sure was a curve thrown at me during the appointment and I did not know how to react because I was in total disbelief.
If you would like to see my others posts you can go to page 16th at the end of the page. (It is the first time that I post in a forum so I’m lost).
JoGlo, I’m sorry for your husband diagnosis, but I’m glad that you are getting good care with a myeloma specialist in a cancer facility and wish all the best.
No, I’m not seeing a multiple myeloma specialist, I go to a clinic so it is a little big complicated to get refer out of the circle that they have, so I’m seeing an oncologist / hematologist that works there.
Once again, many thanks for your input Multibilly and all your help through out this journey with all your knowledge.
When you said “I don't think I would call that a hallmark trait of multiple myeloma” I agree with you one hundred percent. That is one of the reasons It was so shocking, and it helps a lot to see that you understand exactly what happened that day. For sure was a curve thrown at me during the appointment and I did not know how to react because I was in total disbelief.
If you would like to see my others posts you can go to page 16th at the end of the page. (It is the first time that I post in a forum so I’m lost).
Re: What is "Abnormal Protein Band 1"?
Betsy,
When you log in to the Beacon, look at the top of the forum page. There will be a blue link there called “User Control Panel”. Click it. There will be another blue link on the new page that pops up called Board Preferences. Click it. Then select “Yes” for “Allow users to send you private messages”. Then click SUBMIT at the bottom of this page. Folks can then see your other posts and send you private messages.
When you log in to the Beacon, look at the top of the forum page. There will be a blue link there called “User Control Panel”. Click it. There will be another blue link on the new page that pops up called Board Preferences. Click it. Then select “Yes” for “Allow users to send you private messages”. Then click SUBMIT at the bottom of this page. Folks can then see your other posts and send you private messages.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: What is "Abnormal Protein Band 1"?
Thanks Multibilly for your help,
I followed your instructions so It is done!!!
I followed your instructions so It is done!!!
Re: What is "Abnormal Protein Band 1"?
Great ... glad you figured it out.
Last edited by Multibilly on Sat Aug 02, 2014 7:17 pm, edited 1 time in total.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
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