[tatai]

What does "negative for" on a FISH test mean?

by tatai on Thu Jun 28, 2018 1:22 pm

What does it meant on the results of a FISH test when it says "negative for"? For example, "Negative for deletion of the 20q12 locus".

[Multibilly]

Re: What does "negative for" on a FISH test mean?

by Multibilly on Thu Jun 28, 2018 2:26 pm

iFISH tesing of myeloma patients involves a series of "probes" that are each custom tailored to look for specific genetic mutations that are relevant to a myeloma prognosis. In general, a probe not finding a mutation (i.e. being "negative") such as a deletion in the 20q12 region of the chromosomes in the cells they are testing is a good thing. But you should really discuss all of the iFISH results (as well as the rest of your bone marrow biopsy results) page-by-page with your doctor to get the entire picture of what is going on with your disease.

[shebert]

Re: What does "negative for" on a FISH test mean?

by shebert on Fri Jun 29, 2018 9:09 am

My husband's FISH and cytogenetics were normal as well. If these results are fluid, meaning they can change through the course of the disease, we're happy to take the "normal" for now.