Forums
Venclexta (venetoclax) & multiple myeloma
Does this mean anything for multiple myeloma? Currently positive trials on lymphocytic leukemia.
-
vicstir - Name: Vic
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: October 2013
- Age at diagnosis: 39
Re: Venclexta (venetoclax) & multiple myeloma
Sorry, but what do you mean when you ask "Does this mean anything for multiple myeloma?". What "this" are you referring to?
-
JimNY
Re: Venclexta (venetoclax) & multiple myeloma
Jim
Thought it pretty obvious. What I meant was will this drug be any benefit to the treatment of multiple myeloma. Drug being venetoclax (Venclexta).
Thought it pretty obvious. What I meant was will this drug be any benefit to the treatment of multiple myeloma. Drug being venetoclax (Venclexta).
-
vicstir - Name: Vic
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: October 2013
- Age at diagnosis: 39
Re: Venclexta (venetoclax) & multiple myeloma
See the forum post here:
"ABT-199 (venetoclax) & multiple myeloma without t(11;14)" (started Sep 1, 2015)
all the best
"ABT-199 (venetoclax) & multiple myeloma without t(11;14)" (started Sep 1, 2015)
all the best
-
philatour - Who do you know with myeloma?: spouse
Re: Venclexta (venetoclax) & multiple myeloma
Hello!
I was the original poster of that link posted. My mother ended up not going on the ABT-199 (venetoclax) trial. The trial also consisted of Velcade (bortezomib) and dexamethasone. I will say that my mother's hematologist was very, very enthusiastic about ABT-199.
That said, the drug does seem to have a special affinity for the 11;14 translocation, and in the trial my mother was considering, whether or not you were refractory to Velcade was important. Results from phase 1 here:
http://meetinglibrary.asco.org/content/147784-156 (abstract)
https://myelomabeacon.org/docs/asco2015/8580.pdf (poster)
Here is a list of trials using this drug for myeloma. As you can see, it is also being used in other cancers.
I was the original poster of that link posted. My mother ended up not going on the ABT-199 (venetoclax) trial. The trial also consisted of Velcade (bortezomib) and dexamethasone. I will say that my mother's hematologist was very, very enthusiastic about ABT-199.
That said, the drug does seem to have a special affinity for the 11;14 translocation, and in the trial my mother was considering, whether or not you were refractory to Velcade was important. Results from phase 1 here:
http://meetinglibrary.asco.org/content/147784-156 (abstract)
https://myelomabeacon.org/docs/asco2015/8580.pdf (poster)
Here is a list of trials using this drug for myeloma. As you can see, it is also being used in other cancers.
-
BeatMyeloma - Name: BeatMyeloma
- Who do you know with myeloma?: My mother
- When were you/they diagnosed?: Jan. 2008
- Age at diagnosis: 54
Re: Venclexta (venetoclax) & multiple myeloma
I'm just wondering if anyone has any further information or experience with this new drug, Venclexta (venetoclax). I don't want a stem cell transplant and there are trials for Venclexta coming up in a few weeks here in Australia.
I believe this drug is getting pretty good results.
Any information would be greatly appreciated.
Cheers,
Greg
I believe this drug is getting pretty good results.
Any information would be greatly appreciated.
Cheers,
Greg
-
GregSydney - Name: Greg
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2016
- Age at diagnosis: 52
Re: Venclexta (venetoclax) & multiple myeloma
Hi Greg,
There are some promising results for Venclexta as a treatment for multiple myeloma. Although the drug is not approved as a myeloma therapy in any country, as far as I know, it has shown good results in a couple studies.
For example, there were results for Venclexta presented at this year's ASCO meeting. The Beacon has an article that includes information about the results:
"ASCO 2016 Multiple Myeloma Update – Days Four & Five – Potential New Myeloma Therapies," The Myeloma Beacon, June 9, 2016
The article includes this summary:
"The results for Venclexta are very promising. The drug is showing a high level of single-agent activity in patients with the t(11;14) chromosomal abnormality. More importantly, data for an admittedly small group of patients suggests the combination of Venclexta, Velcade, and dexamethasone may be as active in relapsed myeloma as any three-drug combination that includes Velcade – including Darzalex, Velcade, and dexamethasone."
I hope you are able to take part in the Venclexta trial and that the drug proves very effective for you. Maybe you could post here in the forum sometimes about how your treatment with the drug goes? There isn't much information about Venclexta when it's used for multiple myeloma. So what you post could be very helpful to other patients and their families.
Cheers!
There are some promising results for Venclexta as a treatment for multiple myeloma. Although the drug is not approved as a myeloma therapy in any country, as far as I know, it has shown good results in a couple studies.
For example, there were results for Venclexta presented at this year's ASCO meeting. The Beacon has an article that includes information about the results:
"ASCO 2016 Multiple Myeloma Update – Days Four & Five – Potential New Myeloma Therapies," The Myeloma Beacon, June 9, 2016
The article includes this summary:
"The results for Venclexta are very promising. The drug is showing a high level of single-agent activity in patients with the t(11;14) chromosomal abnormality. More importantly, data for an admittedly small group of patients suggests the combination of Venclexta, Velcade, and dexamethasone may be as active in relapsed myeloma as any three-drug combination that includes Velcade – including Darzalex, Velcade, and dexamethasone."
I hope you are able to take part in the Venclexta trial and that the drug proves very effective for you. Maybe you could post here in the forum sometimes about how your treatment with the drug goes? There isn't much information about Venclexta when it's used for multiple myeloma. So what you post could be very helpful to other patients and their families.
Cheers!
Re: Venclexta (venetoclax) & multiple myeloma
Just wondering if anyone has information about what to expect with this drug sequence.
My doctor is trying to get me on a trial for Venclexta (venetoclax). It would be a three-drug combination of Venclexta, Velcade, and dexamethasone. However says not until my m spike rises a bit more. Whatever that means. My M-spike is being deceitful at present. It has been rising for four tests. Then my last blood test it dropped slightly. My doctor was quite shocked by this. We will see what happens next bloods. Either way, she is putting my case or name forward for this trial.
It would be particularly helpful, of course, to hear about any direct experiences with Venclexta.
Thanks Vicki.
My doctor is trying to get me on a trial for Venclexta (venetoclax). It would be a three-drug combination of Venclexta, Velcade, and dexamethasone. However says not until my m spike rises a bit more. Whatever that means. My M-spike is being deceitful at present. It has been rising for four tests. Then my last blood test it dropped slightly. My doctor was quite shocked by this. We will see what happens next bloods. Either way, she is putting my case or name forward for this trial.
It would be particularly helpful, of course, to hear about any direct experiences with Venclexta.
Thanks Vicki.
-
vicstir - Name: Vic
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: October 2013
- Age at diagnosis: 39
Re: Venclexta (venetoclax) & multiple myeloma
Hi Vicki,
There was a presentation at the ASH meeting in December about Venclexta combined with Velcade and dexamethasone in relapsed multiple myeloma patients. You can review the abstract here:
Moreau, P, et al, "Venetoclax Combined with Bortezomib and Dexamethasone for Patients with Relapsed/Refractory Multiple Myeloma," ASH 2016 abstract 975.
From what I can see, the combination seems to do great in patients what have not developed a resistance to Velcade treatment. Those are the "bortezomib non-refractory" patients discussed in the abstract, which includes patients who have never received Velcade, and patients who have had Velcade treatment, but stopped responding to it.
It looks like the most common side effects are GI-related (diarrhea, nausea, and constipation) and headaches, and the severe side effects are mainly low blood counts.
I believe you live in Australia, and Venclexta was recently approved in Australia for the treatment of chronic lymphocytic leukemia. I don't know for certain, but I think it will be a while before it is approved in Australia for multiple myeloma. This means that, for a couple of years yet, the only way to be treated with it in Australia will be in a trial.
Since longer survival with multiple myeloma is all about making sure you can use as many possible treatments as possible while still staying healthy, I think it probably makes sense to give the trial serious consideration -- especially if your doctor thinks it could be a good idea.
Good luck!
There was a presentation at the ASH meeting in December about Venclexta combined with Velcade and dexamethasone in relapsed multiple myeloma patients. You can review the abstract here:
Moreau, P, et al, "Venetoclax Combined with Bortezomib and Dexamethasone for Patients with Relapsed/Refractory Multiple Myeloma," ASH 2016 abstract 975.
From what I can see, the combination seems to do great in patients what have not developed a resistance to Velcade treatment. Those are the "bortezomib non-refractory" patients discussed in the abstract, which includes patients who have never received Velcade, and patients who have had Velcade treatment, but stopped responding to it.
It looks like the most common side effects are GI-related (diarrhea, nausea, and constipation) and headaches, and the severe side effects are mainly low blood counts.
I believe you live in Australia, and Venclexta was recently approved in Australia for the treatment of chronic lymphocytic leukemia. I don't know for certain, but I think it will be a while before it is approved in Australia for multiple myeloma. This means that, for a couple of years yet, the only way to be treated with it in Australia will be in a trial.
Since longer survival with multiple myeloma is all about making sure you can use as many possible treatments as possible while still staying healthy, I think it probably makes sense to give the trial serious consideration -- especially if your doctor thinks it could be a good idea.
Good luck!
Re: Venclexta (venetoclax) & multiple myeloma
Hi Cheryl
Thanks for the links. It all reads well.
Thanks Vicki
Thanks for the links. It all reads well.
Thanks Vicki
-
vicstir - Name: Vic
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: October 2013
- Age at diagnosis: 39
12 posts
• Page 1 of 2 • 1, 2
Return to Treatments & Side Effects