Hi, I have had smoldering myeloma for about four years. It recently exploded 4 weeks ago and went active in a big way. I have started Velcade (bortezomib), cyclophosphamide, and dexamethasone (VCD / CyBorD). Can anyone tell me about what to expect with this drug combination?
I will be having an auto stem cell transplant (SCT) in 4 - 8 months. Any info would be greatly appreciated.
I live on a small island, Tasmania, which is just off the southern coast of Australia. I have not met anyone with multiple myeloma. So it's just me, my haematologist, and my GP, as well as the staff in the chemo unit.
Forums
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Salzmav - Name: Salzmav
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: 2010
- Age at diagnosis: 52
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
Hi,
I also live in Tasmania and was diagnosed with multiple myeloma in March 2014. I have had a stem cell transplant and am on a maintenance program. I believe that we are about the same age. Would be nice to meet up. Where in Tasmania do you live?
Merle
I also live in Tasmania and was diagnosed with multiple myeloma in March 2014. I have had a stem cell transplant and am on a maintenance program. I believe that we are about the same age. Would be nice to meet up. Where in Tasmania do you live?
Merle
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Merle - Name: Merle
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: March 2014
- Age at diagnosis: 55
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
My husband is on the same combination of drugs here in Florida through the Veterans Hospital.
He is 66 and just was diagnosed with smoldering myeloma in September 2014. Due to an increase in lab values, he was started on chemo in October. A bone marrow transplant is planned for early 2015.
He is 66 and just was diagnosed with smoldering myeloma in September 2014. Due to an increase in lab values, he was started on chemo in October. A bone marrow transplant is planned for early 2015.
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
My wife is taking the same chemo. The Velcade by injection, and the dex and cyclophosphamide by IV, along with IV Zofran [ondansetron] and Compazine [prochlorperazine]. Had less side effects than taking dex and cyclophosphamide in pill form. She takes Zofran and Compazine pills in the days after as needed.
Good luck.
Good luck.
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
Hi,
I am in week 2 of cycle 2 of the same combination on the slightly larger island to the north of Tasmania
in Sydney. I was asymptomatic in January of this year, then developed rib pain around August time frame, which a scan confirmed was a lesion. I went for another BMB to confirm protein levels had escalated, and treatment started during the last week in October.
I also have zometa at the start of each cycle by IV. The dexamethasone seems to be the worst in terms of side effects for me, particularly the insomnia, which seems to kick in around 1 am most nights of the week during the cycle. During the first cycle, I also had hiccups for 26 hours and heartburn. This cycle, I am also taking Somac (Protonix; pantoprazole), which definitely helps with heartburn.
Otherwise I seem to be tolerating the other drugs OK.
John
I am in week 2 of cycle 2 of the same combination on the slightly larger island to the north of Tasmania
in Sydney. I was asymptomatic in January of this year, then developed rib pain around August time frame, which a scan confirmed was a lesion. I went for another BMB to confirm protein levels had escalated, and treatment started during the last week in October.I also have zometa at the start of each cycle by IV. The dexamethasone seems to be the worst in terms of side effects for me, particularly the insomnia, which seems to kick in around 1 am most nights of the week during the cycle. During the first cycle, I also had hiccups for 26 hours and heartburn. This cycle, I am also taking Somac (Protonix; pantoprazole), which definitely helps with heartburn.
Otherwise I seem to be tolerating the other drugs OK.
John
Last edited by JohnHamill on Tue Dec 02, 2014 3:25 am, edited 1 time in total.
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JohnHamill - Name: John Hamill
- Who do you know with myeloma?: me
- When were you/they diagnosed?: Jan 2014
- Age at diagnosis: 50
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
Hi there,
I'm in Queensland, and it sounds like we are on the same run up. I'm currently on my 4th chemo cycle and should start harvesting for my stem cells in January for the transplant in February. I should have an actual date in a couple of weeks.
John is right, it's the dex that seems to have the worst effects but not really so bad. Buy a really big wine glass and fill it when you want to
I'm in Queensland, and it sounds like we are on the same run up. I'm currently on my 4th chemo cycle and should start harvesting for my stem cells in January for the transplant in February. I should have an actual date in a couple of weeks.
John is right, it's the dex that seems to have the worst effects but not really so bad. Buy a really big wine glass and fill it when you want to
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Sharon01 - Name: Sharon
- Who do you know with myeloma?: Self
- When were you/they diagnosed?: September 2014
- Age at diagnosis: 48
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
WOW - all us young Aussies! Great to hear from you. Thanks all.
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Salzmav - Name: Salzmav
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: 2010
- Age at diagnosis: 52
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
Had diagnosis of multiple myeloma in 2012 followed by induction of the same drugs and then stem cell transplant early January 2013 followed by second SCT in May due to not complete response as well as neuropathy due to Velcade.
Since then, getting better and better and almost back to normal life - but life will never be normal again. No maintenance drugs and hope to convince you that there is another and very good life afterwards. Although transplants are no holiday and wouldn't want another one.
Since then, getting better and better and almost back to normal life - but life will never be normal again. No maintenance drugs and hope to convince you that there is another and very good life afterwards. Although transplants are no holiday and wouldn't want another one.
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Aina Carolina
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
This topic interests me as well.
I have recently been diagnosed with multiple myeloma due to a fractured vertebrae. M-spike is 13 g/l (1.3 g/dl), kappa light chain 1100, IgG 20, and a bone marrow biopsy with 40-50% abnormal plasma cells. Everything else normal range.
I have started the Velcade, cyclophosphamide, and dexamethasone treatment, to be followed by high-dose cyclophosphamide followed by stem cell collection and finally high-dose melphalan with stem cell transplant.
I too am interested to know what to expect with this treatment. What is the prognosis. Is it a commonly used treatment?
Thanks a lot.
I have recently been diagnosed with multiple myeloma due to a fractured vertebrae. M-spike is 13 g/l (1.3 g/dl), kappa light chain 1100, IgG 20, and a bone marrow biopsy with 40-50% abnormal plasma cells. Everything else normal range.
I have started the Velcade, cyclophosphamide, and dexamethasone treatment, to be followed by high-dose cyclophosphamide followed by stem cell collection and finally high-dose melphalan with stem cell transplant.
I too am interested to know what to expect with this treatment. What is the prognosis. Is it a commonly used treatment?
Thanks a lot.
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Mushe - Name: Mushe
- Who do you know with myeloma?: Wife
- When were you/they diagnosed?: 15 feb 2018
- Age at diagnosis: 34
Re: Velcade, cyclophosphamide & dexamethasone (VCD / CyBorD)
Hi,
My mother underwent 6 cycles of CyBorD (cyclophosphamide, Velcade, and dexamethasone), 3 weeks on and one off, and responded very well to it. Only side effect she has was constipation on the day of IV. And of course she says she used to have scary dreams on the day of IV. Not sure if they are related though!
Her kappa numbers came down from 1140 to around 200. She is now on maintenance Velcade for 4 months now. Her kappa numbers are slightly on rise, but not sure if it was due to the infection she had before drawing blood. Will see in another month. She takes monthly Zometa too.
She is not a candidate for transplant due to heart issues. That’s okay. We have many new drugs on the line. Hope she takes everything as well as she did with this one.
By the way, she has kappa light chain disease
Her kidneys and all vitals are intact. But the issue is with the lesions on her femur and humerus that got her diagnosed with this disease. She had L1 compression fracture after she slipped and fell down. Hope Zometa (zoledronic acid) and pranayama have taken care of the lesions.
My mother underwent 6 cycles of CyBorD (cyclophosphamide, Velcade, and dexamethasone), 3 weeks on and one off, and responded very well to it. Only side effect she has was constipation on the day of IV. And of course she says she used to have scary dreams on the day of IV. Not sure if they are related though!
Her kappa numbers came down from 1140 to around 200. She is now on maintenance Velcade for 4 months now. Her kappa numbers are slightly on rise, but not sure if it was due to the infection she had before drawing blood. Will see in another month. She takes monthly Zometa too.
She is not a candidate for transplant due to heart issues. That’s okay. We have many new drugs on the line. Hope she takes everything as well as she did with this one.
By the way, she has kappa light chain disease
Her kidneys and all vitals are intact. But the issue is with the lesions on her femur and humerus that got her diagnosed with this disease. She had L1 compression fracture after she slipped and fell down. Hope Zometa (zoledronic acid) and pranayama have taken care of the lesions.
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