Prior to my tandem transplants, I went through a round of VDPACE which dropped my Mspike down from 2 to 0.6 I then went through a round of DPACE (the Velcade being left out due to neuropathy--although slight) and it did absolutely nothing.
Now here I am post tandem transplant with a detectable Mspike.
I want to be aggressive, as I'm still in my 40's and I've handled all prior chemo really well.
Question: What are the chances that leaving out the Velcade on the DPACE resulted in the "no action" against the myeloma?
Is it worth having another round of VDPACE to find out?
Thanks, Stan
Forums
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Re: VDPACE
Dear Stan,
Your question is a bit tough to answer without more information (e.g. high risk vs low risk disease at diagnosis, current M spike post transplant, etc), so I would ultimately defer to your treating oncologist. If more treatment at this time is felt to be appropriate and your neuropathy was mild with prior Velcade, it would be reasonable to consider subcutaneous velcade-based consolidation therapy. I am not sure that VD-PACE would be the way to go, though (I would choose a different velcade-based regimen). Alternatively, you can have a discussion with your doctor about the risks and benefits of lenalidomide maintenance therapy. I would not go through treatment just for the sake of finding out if it was the Velcade that gave you the most bang for the buck initially. I would only pursue therapy at the current time if your oncologist feels it is appropriate.
I hope this helps! Good luck!
Pete V.
Your question is a bit tough to answer without more information (e.g. high risk vs low risk disease at diagnosis, current M spike post transplant, etc), so I would ultimately defer to your treating oncologist. If more treatment at this time is felt to be appropriate and your neuropathy was mild with prior Velcade, it would be reasonable to consider subcutaneous velcade-based consolidation therapy. I am not sure that VD-PACE would be the way to go, though (I would choose a different velcade-based regimen). Alternatively, you can have a discussion with your doctor about the risks and benefits of lenalidomide maintenance therapy. I would not go through treatment just for the sake of finding out if it was the Velcade that gave you the most bang for the buck initially. I would only pursue therapy at the current time if your oncologist feels it is appropriate.
I hope this helps! Good luck!
Pete V.
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Dr. Peter Voorhees - Name: Peter Voorhees, M.D.
Beacon Medical Advisor
Re: VDPACE
Thanks Pete,
Your answer was exactly what my transplant oncologist suggested--to a T.
I'm on maintenance Revlimid and if numbers stop dropping we will add subcutaneous Velcade.
That's comforting to hear it from another source--thanks
At diagnosis, my Mspike was 5.5. After rv/dx/Velcade it dropped to 3. Then VDPACE dropped it to 0.6. But unfortunately I immediately got sepsis and, as a result, had to stop all chemo for 4 months. So Mspike went up to a 2.5. After a round of DPACE no drop. Then two SCT's later it dropped to 0.4 and it is still slowly going down. (it's been 10 weeks since last SCT).
Thanks for your input.
Your answer was exactly what my transplant oncologist suggested--to a T.
I'm on maintenance Revlimid and if numbers stop dropping we will add subcutaneous Velcade.
That's comforting to hear it from another source--thanks
At diagnosis, my Mspike was 5.5. After rv/dx/Velcade it dropped to 3. Then VDPACE dropped it to 0.6. But unfortunately I immediately got sepsis and, as a result, had to stop all chemo for 4 months. So Mspike went up to a 2.5. After a round of DPACE no drop. Then two SCT's later it dropped to 0.4 and it is still slowly going down. (it's been 10 weeks since last SCT).
Thanks for your input.
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Stann
Re: VDPACE
My husband's multiple myeloma has progressed to Extramedullary Myeloma in the last month with soft tissue tumors in his lung, around his clavical, and in lymph nodes of his throat. He will be going into the hospital for 4 days of VDPACE. What can we expect as far as side effects go?
Thank you
Thank you
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mw81 - Name: Michelle
- Who do you know with myeloma?: husband
- When were you/they diagnosed?: 10/5/2011
- Age at diagnosis: 54
Re: VDPACE
I have a little experience not with VDPACE but VTDPACE. Thalidomide was added to the gemish. It knocked down my multiple myeloma markers but they returned to their earlier levels in a few months. I acquired pneumonia soon after treatment and spent a fun filled week in the hospital. Within weeks I noticed the onset of peripheral neuropathy which is still with me two years later. My prostate swelled and I needed catherization and eventually a rotr-router. Bottom line: Not something to be anticipated with enthusiasm.
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garyeblau
5 posts
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