[DexMed]

Single M-spike is now two M-spikes - significance?

by DexMed on Sun May 25, 2014 1:15 am

I have been smoldering for 4 years under watchful waiting. My M spike has been in 1.4 to 1.6 range. Recent blood work showed M spike in two regions, beta and gamma, with readings of 0.9 each. Does it mean my M spike is .9 + .9 = 1.8.

Can someone explain the significance of M-spike in two regions as opposed to a single number?

[Maro]

Re: Single M-spike is now two M-spikes - significance?

by Maro on Sun May 25, 2014 6:30 am

Hello DexMed.

My mother has 2 spikes. She is smoldernig. One in beta region and one in the more common gamma region (it is apparently more common with IgA)

It does not affect prognosis or response to treatment nor does it determine the risk of progression.

That is all I know about it, hope it helps in re assuring you

Maro

[DexMed]

Re: Single M-spike is now two M-spikes - significance?

by DexMed on Mon May 26, 2014 6:30 pm

Thanks, Maro. I am IgA/ Kappa, too.

[Dr. Jatin Shah]

Re: Single M-spike is now two M-spikes - significance?

by Dr. Jatin Shah on Mon May 26, 2014 11:29 pm

That is correct -- we typically add the 2 two but also follow each spike individually as well. For IgA, the m spike can be challenging and it is also very helpful to follow total IgA levels. There is no difference in prognosis.

[DexMed]

Re: Single M-spike is now two M-spikes - significance?

by DexMed on Tue May 27, 2014 8:31 am

Dr. Shah, I appreciate for your prompt response.