Dad was diagnosed IbG multiple myeloma in 2010. He's had MANY treatments. Right now, it's been suggested to do high dose Cytoxan / dex since bendamustine [Treanda] and dex are hard on him and disease has progressed some. I just heard about PAC-MED so I will inquire about that today. He's never had VDT-PACE.
Any treatment ideas for aggressive myeloma are welcome. Thanks, if you have a thought to share. We need ideas at this point.
Yes, dad sees a multiple myeloma specialist. Thank you.
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Re: Treatment ideas for aggressive multiple myeloma?
Hi Carla,
Looking for a little more background info so folks on this forum can help.
You say your Dad has had "many treatments". Were they all alkylating agents like Cytoxan and bendamustine? Which drug combos has he used over time and what were the results of using these drugs?
What are his major cytogenetic risks and/or other factors that led to this current choice of drugs and his classification as "aggressive"?
Looking for a little more background info so folks on this forum can help.
You say your Dad has had "many treatments". Were they all alkylating agents like Cytoxan and bendamustine? Which drug combos has he used over time and what were the results of using these drugs?
What are his major cytogenetic risks and/or other factors that led to this current choice of drugs and his classification as "aggressive"?
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Treatment ideas for aggressive multiple myeloma?
I'm sorry I am just now replying to your questions.
As it turns out he was treated with bendamustine (Treanda) / dex, and his multiple myeloma numbers have been coming down. Unfortunately, his WBC, RBC and especially his platelets have been coming down.
My next question will be: Can platelets recover and can his bone marrow start producing after having bendamustine and dex?
As it turns out he was treated with bendamustine (Treanda) / dex, and his multiple myeloma numbers have been coming down. Unfortunately, his WBC, RBC and especially his platelets have been coming down.
My next question will be: Can platelets recover and can his bone marrow start producing after having bendamustine and dex?
Re: Treatment ideas for aggressive multiple myeloma?
Carla:
According to this link, the lower RBC and WBC counts are a temporary thing:
http://chemocare.com/chemotherapy/drug-info/bendamustine.aspx
The following bendamustine side effects are common (occurring in greater than 30%) for patients taking bendamustine:
Low blood counts. Your white and red blood cells and platelets may TEMPORARILY decrease. This can put you at increased risk for infection, anemia and/or bleeding.
Nadir, meaning low point - Nadir is the point in time between chemotherapy cycles in which you experience lowest blood counts.
Nadir: 14 to 21 days
Recovery: 28 days
According to this link, the lower RBC and WBC counts are a temporary thing:
http://chemocare.com/chemotherapy/drug-info/bendamustine.aspx
The following bendamustine side effects are common (occurring in greater than 30%) for patients taking bendamustine:
Low blood counts. Your white and red blood cells and platelets may TEMPORARILY decrease. This can put you at increased risk for infection, anemia and/or bleeding.
Nadir, meaning low point - Nadir is the point in time between chemotherapy cycles in which you experience lowest blood counts.
Nadir: 14 to 21 days
Recovery: 28 days
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
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