[Lacerta]

Treatment for multiple myeloma with translocation t(14;16)?

by Lacerta on Sun Apr 17, 2016 2:13 pm

Have specific therapeutic strategies been developed for myeloma patients with translocation t(14;16)?

[Multibilly]

Re: Treatment for multiple myeloma with translocation t(14;1

by Multibilly on Sun Apr 17, 2016 4:01 pm

Lacerta,

You may want to to review the Mayo mSMART guidelines:

https://www.msmart.org/about.html

And you may want to read through this article, especially if your kidney function is in good shape.

https://myelomabeacon.org/forum/article-about-cytogenetics-chromosomal-abnormalities-t6271.html

"...Patients are considered to have high-risk disease if FISH studies demonstrate one of the following abnormalities: t(14;16), t(14;20), or loss of p53 gene locus (del(17p) or monosomy. There is some controversy about whether there is a true adverse biological risk associated with t(14;16) multiple myeloma. This form of multiple myeloma is more frequently associated with acute renal failure as the MDE at diagnosis. Thus in clinical trials that typically exclude patients with renal failure an adverse prognosis associated with t(14;16) multiple myeloma may not be seen, in contrast to studies which include all patients seen in a given institution where an unfavorable outcome has been observed. In one study, after adjusting for renal failure, the outcome of t(14;16) was comparable to other standard-risk subtypes of multiple myeloma"