My grandfather was diagnosed with Multiple Myeloma in June 2012. He completed the chemotherapy - Velcade last week.
Still feels very weak and complains of lots of tingling sensation in legs. Problems standing up and walking also because of the sensation. Its similar in nature to when normal people feel the sensation when blood circulation stops momentarily,but a lot more severe.
Is this a normal side effect. If so, how long does this continue and is there anything that can be done to provide relief?
Any comments would be appreciated.
Thanks!
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6 posts
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rd2012 - Name: R D
- Who do you know with myeloma?: Grandfather
- When were you/they diagnosed?: JUne 2012
- Age at diagnosis: 78
Re: Tingling Sensation in legs after Chemo
I am sorry to hear about your Dad. I wish you the best during treatment.
Please note I am not a doctor and I recommend your dad see his doctor about this. It sounds like Peripheral Neuropathy which can be a side effect of Velcade. My husband had this in his hands.
His doctor will discuss with him what can be done.
Please note I am not a doctor and I recommend your dad see his doctor about this. It sounds like Peripheral Neuropathy which can be a side effect of Velcade. My husband had this in his hands.
His doctor will discuss with him what can be done.
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DiannaJ
Re: Tingling Sensation in legs after Chemo
DiannaJ wrote:
> I am sorry to hear about your Grandfather. I wish him the best during treatment.
>
> Please note I am not a doctor and I recommend your grandfather see his doctor about
> this. It sounds like Peripheral Neuropathy which can be a side effect of
> Velcade. My husband had this in his hands.
>
> His doctor will discuss with him what can be done.
> I am sorry to hear about your Grandfather. I wish him the best during treatment.
>
> Please note I am not a doctor and I recommend your grandfather see his doctor about
> this. It sounds like Peripheral Neuropathy which can be a side effect of
> Velcade. My husband had this in his hands.
>
> His doctor will discuss with him what can be done.
-
DiannaJ
Re: Tingling Sensation in legs after Chemo
DiannaJ wrote:
> I am sorry to hear about your Grandfather. I wish him the best during treatment.
>
> Please note I am not a doctor and I recommend your grandfather see his doctor about
> this. It sounds like Peripheral Neuropathy which can be a side effect of
> Velcade. My husband had this in his hands.
>
> His doctor will discuss with him what can be done.
> I am sorry to hear about your Grandfather. I wish him the best during treatment.
>
> Please note I am not a doctor and I recommend your grandfather see his doctor about
> this. It sounds like Peripheral Neuropathy which can be a side effect of
> Velcade. My husband had this in his hands.
>
> His doctor will discuss with him what can be done.
-
DiannaJ
Re: Tingling Sensation in legs after Chemo
Dear rd2012,
I agree completely with DiannaJ. This is almost certainly peripheral neuropathy from Velcade -- a fairly common side effect of the drug. Just out of curiosity, did your Grandfather receive the Velcade as an IV infusion or as a shot?
Regardless, it sounds like treatment is finished. As such, the symptoms are likely to get better over time. In a large phase 3 study evaluating the combination of melphalan, prednisone and Velcade for newly-diagnosed myeloma patients, 80% of patients experienced improvement of their neuropathy (it tooke on average 2 months to experience improvement) and 60% complete resolution.by 6 months (on average). In my experience, with longer follow-up, the percentages of patients with improvement/resolution continues to improve.
If there is a significant amount of discomfort associated with this, there are medications available to help with the problem, realizing that these medications can have their own set of side effects. Gabapentin (Neurontin), pregabalin (Lyrica) and duloxetine (Cymbalta) are commonly used, for example. I would definitely bring this to the attention of your Grandfather's oncologist.
Thanks and good luck!
Pete V.
I agree completely with DiannaJ. This is almost certainly peripheral neuropathy from Velcade -- a fairly common side effect of the drug. Just out of curiosity, did your Grandfather receive the Velcade as an IV infusion or as a shot?
Regardless, it sounds like treatment is finished. As such, the symptoms are likely to get better over time. In a large phase 3 study evaluating the combination of melphalan, prednisone and Velcade for newly-diagnosed myeloma patients, 80% of patients experienced improvement of their neuropathy (it tooke on average 2 months to experience improvement) and 60% complete resolution.by 6 months (on average). In my experience, with longer follow-up, the percentages of patients with improvement/resolution continues to improve.
If there is a significant amount of discomfort associated with this, there are medications available to help with the problem, realizing that these medications can have their own set of side effects. Gabapentin (Neurontin), pregabalin (Lyrica) and duloxetine (Cymbalta) are commonly used, for example. I would definitely bring this to the attention of your Grandfather's oncologist.
Thanks and good luck!
Pete V.
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Dr. Peter Voorhees - Name: Peter Voorhees, M.D.
Beacon Medical Advisor
6 posts
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