Hello,
I'm not sick, but did regular blood test and want someone to explain it to me please ...
Age : 42
Biochemistry:
Total Protein 79 g/L (63 - 83)
Albumin * 53 g/L (34 - 50)
Globulin 26 g/L (19 - 35)
Protein Electrophoresis :
Serum Protein 79 g/l (63 - 83)
Albumin 60.0 % (51.0 - 65.6)
Alpha 1 Globulin 3.4 % (3.1 - 6.1)
Alpha 2 Globulin 7.2 % (7.1 - 14.1)
Beta 1 Globulin 5.8 % (4.9 - 7.3)
Beta 2 Globulin 5.6 % (3.3 - 7.2)
Gamma Globulin 18.0 % (11.5 - 23.1)
Albumin 47.4 g/l (35.5 - 48.6)
Alpha 1 Globulin 2.7 g/l (2.0 - 4.2)
Alpha 2 Globulin 5.7 g/l (5.1 - 10.3)
Beta 1 Globulin 4.6 g/l (3.5 - 5.5)
Beta 2 Globulin 4.4 g/l (2.3 - 5.2)
Gamma Globulin 14.2 g/l (7.7 - 17.3)
Paraprotein level 5 g/l
Discrete band in the gamma region.
Serum Protein Immunofixation:
IgG Lambda paraprotein detected.
Biochemistry:
Immunoglobulin G 15.50 g/L (7.0 - 16.0)
Immunoglobulin A 2.65 g/L (0.70 - 4.00)
Immunoglobulin M 0.75 g/L (0.40 - 2.30)
Forums
5 posts
• Page 1 of 1
-
huali - Who do you know with myeloma?: Nobody
- When were you/they diagnosed?: Not diagnosed
- Age at diagnosis: 42
Re: Interpretation of test results?
Hello Huali:
Glad to hear that you are not sick. Ideally the paraprotein level should be zero. If its not, that falls under the umbrella of multiple myeloma or one of its precursor conditions. In the US, the more common unit of measure is grams per deca-liter. That would be an M-Spike of 0.5 in your case. The condition at your stage is called MGUS, which comes from "Monoclonal Gamopathy of Undetermined Significance". At that level of M-Spike it is possible for active multiple myeloma to develop, but quite rare. There is great variability from person to person, but when the M-Spike creeps up to the 3 range, or so, for many, it starts turning towards smoldering or active multiple myeloma. It is much better to catch this at the MGUS or Smoldering stage than in the active stage. Unfortunately many people first encounter this in the active multiple myeloma stage, so in that regard, you are fortunate.
I don't want to hit you with too much at one time, but for your situation, the approach is watch and wait. Keep in mind that obviously, my comments are not a medical opinion in any way. It is important that you have a doctor very knowledgeable in multiple myeloma to watch this at an appropriate period (maybe six months at a time). If it stays steady or moves up very slowly, you will be fine for a long long time. If it moves up more quickly, then you will want to start to initiate induction treatment before any bad impacts of the condition kick in.
Based on what you mentioned, you appear to have plenty of time to monitor this and learn about your options, way too early to panic. But, you do want to get educated, specifically, there are several clinical trials right now that are looking at knocking down the M-Spike when its in the MGUS or Smoldering stages. Good luck.
Glad to hear that you are not sick. Ideally the paraprotein level should be zero. If its not, that falls under the umbrella of multiple myeloma or one of its precursor conditions. In the US, the more common unit of measure is grams per deca-liter. That would be an M-Spike of 0.5 in your case. The condition at your stage is called MGUS, which comes from "Monoclonal Gamopathy of Undetermined Significance". At that level of M-Spike it is possible for active multiple myeloma to develop, but quite rare. There is great variability from person to person, but when the M-Spike creeps up to the 3 range, or so, for many, it starts turning towards smoldering or active multiple myeloma. It is much better to catch this at the MGUS or Smoldering stage than in the active stage. Unfortunately many people first encounter this in the active multiple myeloma stage, so in that regard, you are fortunate.
I don't want to hit you with too much at one time, but for your situation, the approach is watch and wait. Keep in mind that obviously, my comments are not a medical opinion in any way. It is important that you have a doctor very knowledgeable in multiple myeloma to watch this at an appropriate period (maybe six months at a time). If it stays steady or moves up very slowly, you will be fine for a long long time. If it moves up more quickly, then you will want to start to initiate induction treatment before any bad impacts of the condition kick in.
Based on what you mentioned, you appear to have plenty of time to monitor this and learn about your options, way too early to panic. But, you do want to get educated, specifically, there are several clinical trials right now that are looking at knocking down the M-Spike when its in the MGUS or Smoldering stages. Good luck.
-
JPC - Name: JPC
Re: Interpretation of test results?
Hi Huali,
Sorry to hear about this discovery. But as JPC mentioned, this is most likely a case of MGUS. Most folks with MGUS go through life none the worse for it and never even know they have it.
As JPC mentioned, it's always best to be seen by a multiple myeloma specialist regardless if you have MGUS, smoldering multiple myeloma or symptomatic multiple myeloma. These specialists are a different breed of hematologists/oncologists that live and breather multiple myeloma on a daily basis. There are some additional tests that a specialist would run to further characterize your situation - and it's always good to have a multiple myeloma specialist on your side.
If you let us know what city you are in, folks on this site can make some recommendations as to where find these specialists.
Take care.
Sorry to hear about this discovery. But as JPC mentioned, this is most likely a case of MGUS. Most folks with MGUS go through life none the worse for it and never even know they have it.
As JPC mentioned, it's always best to be seen by a multiple myeloma specialist regardless if you have MGUS, smoldering multiple myeloma or symptomatic multiple myeloma. These specialists are a different breed of hematologists/oncologists that live and breather multiple myeloma on a daily basis. There are some additional tests that a specialist would run to further characterize your situation - and it's always good to have a multiple myeloma specialist on your side.
If you let us know what city you are in, folks on this site can make some recommendations as to where find these specialists.
Take care.
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Interpretation of test results?
Thank you JPC, thank you Multibilly.
I forgot to mention that I have thalassemia minor since born.
I forgot to mention that I have thalassemia minor since born.
-
huali - Who do you know with myeloma?: Nobody
- When were you/they diagnosed?: Not diagnosed
- Age at diagnosis: 42
Re: Interpretation of test results?
Hi Huali,
Thalassemia can cause what is known as a polyclonal gammopathy, as opposed to a monoclonal gammopathy such as MGUS.
I'm not a doc, but your electrophoresis and immunofixation test results seem to suggest a monoclonal gammopathy. However, this is definitely a situation where you want a multiple myeloma specialist to be looking at your serum immunofixation (IFE) and serum electrophoresis (SPEP) test results to truly determine if a polyclonal or monoclonal gammopathy (or both) might be in play. A multiple myeloma specialist would also likely run what is known as a serum free light chain assay and a 24 hour urine protein electrophoresis (UPEP) test to help confirm if this is indeed a monoclonal gammopathy, as well as to further characterize a diagnosis of MGUS.
Thalassemia can cause what is known as a polyclonal gammopathy, as opposed to a monoclonal gammopathy such as MGUS.
I'm not a doc, but your electrophoresis and immunofixation test results seem to suggest a monoclonal gammopathy. However, this is definitely a situation where you want a multiple myeloma specialist to be looking at your serum immunofixation (IFE) and serum electrophoresis (SPEP) test results to truly determine if a polyclonal or monoclonal gammopathy (or both) might be in play. A multiple myeloma specialist would also likely run what is known as a serum free light chain assay and a 24 hour urine protein electrophoresis (UPEP) test to help confirm if this is indeed a monoclonal gammopathy, as well as to further characterize a diagnosis of MGUS.
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
5 posts
• Page 1 of 1