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Stringent complete response (sCR) time to progression?
I just found out I've reached a stringent complete response (sCR). How long does this last on average?
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Benny - Name: BM1971
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: 12/2/16
- Age at diagnosis: 45
Re: Stringent complete response (sCR) time to progression?
Hi Benny,
Congrats on sCR! That's fantastic.
I am not an expert, so hopefully someone with more knowledge will jump in. I did find an article related to stem cell transplant outcomes that showed a median time to progression (TTP) of 50 months for those achieving sCR (see the reference below). Remember a median doesn't tell us anything about how the 50 percent who last longer than 50 months are distributed.
You haven't had a transplant, have you? That brings me to my next point, which is I know there has been some research recently indicating that a transplant's added value in TTP may be greater when it deepens a patient's response vs. when sCR was already achieved going in. In other words, the post-transplant data *could* be fairly applicable to your situation. This is, of course, not a settled area of research. If I can find the link I will update it. (There may be others, but I believe the research I saw was an abstract at ASH 2017.)
One thing that's endlessly frustrating is that with so many different expressions of this disease and variations in patient age and health status, I don't think the medians are super helpful. I kept wanting to ask my doctor: "But what's the median for 42-year-old women with my cytogenetics?" and that just doesn't exist. It's all terribly unpredictable, so enjoy your wins!!
Best,
W
Reference:
Kapoor, P, et al, "Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma," Journal of Clinical Oncology, Dec 20, 2013 (full text of article)
Related Beacon news article:
"Degree Of Complete Response After Transplant May Affect Survival In Myeloma," The Myeloma Beacon, Feb 26, 2014
Congrats on sCR! That's fantastic.
I am not an expert, so hopefully someone with more knowledge will jump in. I did find an article related to stem cell transplant outcomes that showed a median time to progression (TTP) of 50 months for those achieving sCR (see the reference below). Remember a median doesn't tell us anything about how the 50 percent who last longer than 50 months are distributed.
You haven't had a transplant, have you? That brings me to my next point, which is I know there has been some research recently indicating that a transplant's added value in TTP may be greater when it deepens a patient's response vs. when sCR was already achieved going in. In other words, the post-transplant data *could* be fairly applicable to your situation. This is, of course, not a settled area of research. If I can find the link I will update it. (There may be others, but I believe the research I saw was an abstract at ASH 2017.)
One thing that's endlessly frustrating is that with so many different expressions of this disease and variations in patient age and health status, I don't think the medians are super helpful. I kept wanting to ask my doctor: "But what's the median for 42-year-old women with my cytogenetics?" and that just doesn't exist. It's all terribly unpredictable, so enjoy your wins!!
Best,
W
Reference:
Kapoor, P, et al, "Importance of achieving stringent complete response after autologous stem-cell transplantation in multiple myeloma," Journal of Clinical Oncology, Dec 20, 2013 (full text of article)
Related Beacon news article:
"Degree Of Complete Response After Transplant May Affect Survival In Myeloma," The Myeloma Beacon, Feb 26, 2014
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willow75 - Who do you know with myeloma?: me
- When were you/they diagnosed?: 2017
- Age at diagnosis: 42
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