Hi,
My husband just had his stem cell collection this week. He had Cytoxan on Thursday, the 13 of August. Starting the Monday after that, he had two shots of Neupogen everyday. His team thought he would have no problems collecting cells.
Day one wasn't good, 1.5 million. When the blood work for day two came in, they told us it looked like we would be lucky to get enough for one transplant. 1,3 million that day. His doctor ordered Mozobil Tuesday night, and Wednesday 4 million, and 3.5 million Thursday.
I was wondering if other people with no bone lesions had problems getting enough cells without Mozobil?
Keith is 53 and has had a fairly smooth road so far with all his treatments.
I am curious about the lack of bone lesions and difficult with mobilizing stem cells. Are they related?
Ellen
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Ellen w - Name: Ellen
- Who do you know with myeloma?: Husband
- When were you/they diagnosed?: January 2015
- Age at diagnosis: 52
Re: Stem cell collection with no bone lesions
Hi Ellen,
I'm glad your husband was able to harvest enough stem cells despite the problems he had at the beginning of the harvesting process.
To be honest, I've never read here, or anywhere else, of bone lesions being a factor that affects whether or not someone is likely to have a successful stem cell harvest. It makes sense that having a lot of lesions might have an effect, but it's not something I've heard mentioned here before.
What you usually here is that there is a greater risk of people having problems during the collection process if they've been treated with Revlimid, particularly if they've been treated with the drug for a long time. With Mozobil available to help with mobilization, there are fewer concerns that Revlimid can cause problems. But it used to be the main concern.
Has your husband been treated with Revlimid?
As it turns out, I did find a Korean study published last year that suggests that having bone lesions in at least three different parts of the body can lead to mobilization problems. Here's a link to the study:
http://www.ncbi.nlm.nih.gov/pubmed/24764270
"Advanced lytic lesion is a poor mobilization factor in peripheral blood stem cell collection in patients with multiple myeloma"
As you said, though, this wouldn't explain what happened in your husband's case.
I'm glad your husband was able to harvest enough stem cells despite the problems he had at the beginning of the harvesting process.
To be honest, I've never read here, or anywhere else, of bone lesions being a factor that affects whether or not someone is likely to have a successful stem cell harvest. It makes sense that having a lot of lesions might have an effect, but it's not something I've heard mentioned here before.
What you usually here is that there is a greater risk of people having problems during the collection process if they've been treated with Revlimid, particularly if they've been treated with the drug for a long time. With Mozobil available to help with mobilization, there are fewer concerns that Revlimid can cause problems. But it used to be the main concern.
Has your husband been treated with Revlimid?
As it turns out, I did find a Korean study published last year that suggests that having bone lesions in at least three different parts of the body can lead to mobilization problems. Here's a link to the study:
http://www.ncbi.nlm.nih.gov/pubmed/24764270
"Advanced lytic lesion is a poor mobilization factor in peripheral blood stem cell collection in patients with multiple myeloma"
As you said, though, this wouldn't explain what happened in your husband's case.
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Jonah
Re: Stem cell collection with no bone lesions
When I had my autologous stem cell transplant (ASCT), I was very surprised to find they could not collect enough cells to store for a possible second transplant. I too had no bone lesions and was generally healthy except, of course, for the myeloma. Perhaps just another example of how this disease presents itself so differently in different patients.
-- Donna
-- Donna
Re: Stem cell collection with no bone lesions
Greetings,
I've never heard that there was a relationship between lesions and the ability to harvest stem cells. I had bone lesions and harvested enough for two transplants.
Best to you, Phil
I've never heard that there was a relationship between lesions and the ability to harvest stem cells. I had bone lesions and harvested enough for two transplants.
Best to you, Phil
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Phil
Re: Stem cell collection with no bone lesions
Mechanically, there could be an explanation.
If his disease is located in his marrow (long bones), and he has a higher Protein level, then perhaps his RBC's are being stressed in getting out to his vascular system--so they can be harvested.
The stimulants make his RBC's all ready to dance--but the door to the dance club is perchance blocked by multiple myeloma or Proteins ?
This is a strange disease.
If his disease is located in his marrow (long bones), and he has a higher Protein level, then perhaps his RBC's are being stressed in getting out to his vascular system--so they can be harvested.
The stimulants make his RBC's all ready to dance--but the door to the dance club is perchance blocked by multiple myeloma or Proteins ?
This is a strange disease.
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Rneb
Re: Stem cell collection with no bone lesions
Just had a SCT last month. Neupogen injections 4 days got little; mobozil 2 days got 15 million. No bone lesions, so not sure that is the issue.
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Rick R
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