[gmarv]

Slow period for new multiple myeloma drugs?

by gmarv on Mon Nov 06, 2017 3:37 pm

Is it just me, or are we in slow period of new drugs coming out now.The last new drug i have read about is Darzalex and Empliciti. Does anybody know the names of some of the newer drugs in the pipeline?

[kshornb]

Re: Slow period for new multiple myeloma drugs?

by kshornb on Mon Nov 06, 2017 4:02 pm

Ninlaro. It's similar to Velcade.

[Multibilly]

Re: Slow period for new multiple myeloma drugs?

by Multibilly on Mon Nov 06, 2017 6:39 pm

Gosh, I feel like we've been blessed with so many new treatments in the past couple of years, including all of the new monoclonal antibody drugs and an oral proteasome inhibitor (Ninlaro). Having said that, there's also a bunch of new drugs in the pipeline. Below are some of the more prominent ones that I've picked up on (there's probably more). What I think is exciting about many of these new drugs is that they utilize altogether new approaches to managing myeloma.

Anti-BCMA CAR-T cell therapies (e.g. GSK2857916)
Vorinostat (another HDAC inhibitor)
Plitidepsin (eEF1A2 blocker)
Marizomib (another proteasome inhibitor)
Venetoclax (Bcl-2 inhibitor)
Selinexor (SINE XPO1 antagonist)

[gmarv]

Re: Slow period for new multiple myeloma drugs?

by gmarv on Tue Nov 07, 2017 1:23 pm

Thanks for the responses, guys.That is really good news to hear about the new drugs in the pipe­line.