Dear all,
I was at a routine blood and urea test and I paid for s-elfo and immunoglobulin analysys too (My age: 30)
All of my readings are in the normal range (wbc, rbc, esr, creatinine, c-reactive, rheuma-factor, calcium etc.)
I was tested after a heavy viral influenza infection. I seemed healthy 5-7 days before testing, but get a serious cold the day after the testing. A sore throat started at the day of the testing. Can these "infections" cause elevated igA?
ELFO says:
Electrophoresis
Albumin 66.0 % 50.0 - 66.5
Alfa1-globulin 2.2 % 1.5 - 4.5
Alfa2-globulin 8.4 % 7.5 - 12.5
Beta1-globulin 7.0 % 5.1 - 10.1
Beta2-globulin 4.2 % 2.0 - 5.0
Gamma-globulin 12.2 % 10.0 - 18.0
No mention for M-spike (paraprotein). But no mention for zero M-spike too...
Imuunoglobulins:
Immunglobulinok
IgG 1.455 g/dl 0.0700 - 1.700
IgA 0.540 g/dl * 0.0700 - 0.450
IgM 0.057 g/dl 0.0500 - 0.270
No mention for M-spike, but no mention for zero M-spike too.
Total protein: 7.71 g/dl 6.50 - 8.50
Albumin: 4.60 g/dl 3.50 - 5.00
Urine analysis: Protein: not detectable (but it was just morning urine and normal urine test, not 24h electrophoresis!)
I am pretty scared if I have MGUS because of this elevated IgA. The assistant at the labor says not to worry too much because of the small amount of IgA elevation because all of my other tests was pretty excellent...
What is your opinion about this?
Forums
5 posts
• Page 1 of 1
Re: Slightly elevated IgA - MGUS? Myeloma?
George,
Your IgA is just moderately elevated and it really sounds like you don't have any sort of monoclonal gammopathy like MGUS or multiple myeloma, which is very welcome news. So, I would not worry about MGUS. The elevated IgA may indeed be the result of your recent infection.
I'm going to guess that your doc may simply ask you to get your IgA re-tested in a couple of months .... after you've got some more time to get your recent viral influenza episode behind you. For good measure, at that time you might ask to get what is known as serum immunofixation (IFE), which will tell you pretty accurately if you have any monoclonal protein present or not.
Best of luck with all this and let us know how things turn out.
Your IgA is just moderately elevated and it really sounds like you don't have any sort of monoclonal gammopathy like MGUS or multiple myeloma, which is very welcome news. So, I would not worry about MGUS. The elevated IgA may indeed be the result of your recent infection.
I'm going to guess that your doc may simply ask you to get your IgA re-tested in a couple of months .... after you've got some more time to get your recent viral influenza episode behind you. For good measure, at that time you might ask to get what is known as serum immunofixation (IFE), which will tell you pretty accurately if you have any monoclonal protein present or not.
Best of luck with all this and let us know how things turn out.
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Slightly elevated IgA - MGUS? Myeloma?
Dear Multibilly,
Thanks for your quick answer. You give me a little hope
I was totally depressed.
But I am still a little bit confused ... Shouldn't the lab see from elfo if there is an M-spike there?
If yes, why don't they write on the paper "no paraprotein detected"?
Thanks for your quick answer. You give me a little hope
I was totally depressed. But I am still a little bit confused ... Shouldn't the lab see from elfo if there is an M-spike there?
If yes, why don't they write on the paper "no paraprotein detected"?
Re: Slightly elevated IgA - MGUS? Myeloma?
George,
The ELFO, as you call it, is where a pathologist would make a notation if any monoclonal protein (aka M-protein, paraprotein, M-spike, etc) was present, and how much was present. This test is commonly referred to as a serum protein electrophoresis or "SPEP" test.
The monoclonal protein amount usually appears as a separate notation in a section different from where the other values are listed (albumin, etc). But if none was found, the pathologist may simply not have bothered to indicate it.
Note that if you are looking at an online summary of the SPEP, it may not be listed in that online summary. You often times have to look at the original lab report that was provided to your doctor to find this separate notation on the monoclonal protein measurement.
There is also a separate test known as the serum immunofixation (IFE) that will tell you pretty accurately whether or not there is monoclonal protein present in your blood and what kind it is. But it won't tell you the amount like the SPEP would. An IFE is a "qualitative" test, unlike the SPEP, which is a "quantitative" test.
The ELFO, as you call it, is where a pathologist would make a notation if any monoclonal protein (aka M-protein, paraprotein, M-spike, etc) was present, and how much was present. This test is commonly referred to as a serum protein electrophoresis or "SPEP" test.
The monoclonal protein amount usually appears as a separate notation in a section different from where the other values are listed (albumin, etc). But if none was found, the pathologist may simply not have bothered to indicate it.
Note that if you are looking at an online summary of the SPEP, it may not be listed in that online summary. You often times have to look at the original lab report that was provided to your doctor to find this separate notation on the monoclonal protein measurement.
There is also a separate test known as the serum immunofixation (IFE) that will tell you pretty accurately whether or not there is monoclonal protein present in your blood and what kind it is. But it won't tell you the amount like the SPEP would. An IFE is a "qualitative" test, unlike the SPEP, which is a "quantitative" test.
-
Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Slightly elevated IgA - MGUS? Myeloma?
Ok, there is no such a note on the paper, I have the original one
It was the serum protein electrophoresis test, that for sure.
The assistant at the lab told me that, if there is serious problem, the pathologist always notes it: other tests or measurements needed.
In my case, she said: just retest it in a 0.5 - 1 year.
My only problem: I couldn't find a single article about elevated IgA after or the same time at viral or bacterial infection.
It was the serum protein electrophoresis test, that for sure.
The assistant at the lab told me that, if there is serious problem, the pathologist always notes it: other tests or measurements needed.
In my case, she said: just retest it in a 0.5 - 1 year.
My only problem: I couldn't find a single article about elevated IgA after or the same time at viral or bacterial infection.
5 posts
• Page 1 of 1