[majolica]

Serum Immunofixation Question

by majolica on Thu Sep 29, 2011 2:26 pm

Hello Again,
Hoping someone can answer this question. When I had a serum immunofixation done 11/06 there was abnormal marks on the labs. The hematologist never mentioned anything, he is retired now. Does this have any meaning? Could this be a transit thing....Would the abnormal finding be temporary? I just got a copy of the labs this week. I am IgG lambda mgus.

IGA 143
1GG 997
IGM 92
KAPPA 135 L (200-400)
LAMBDA 210 (110-240)
K/L 0.64 L (1.24-2.69)
M-SPIKE .5

[Dr. Edward Libby]

Re: Serum Immunofixation Question

by Dr. Edward Libby on Wed Oct 05, 2011 11:16 am

Your current results are really all that matter.

[bens]

Re: Serum Immunofixation Question

by bens on Fri Oct 21, 2011 12:30 pm

My wife's IgG elevated from 4.3 to 5.2 but her M-Spike stayed at 3.1 between two tests two weeks apart. Is this a reason to be concerned? I read that the amount of IgG includes both the so-called normal IgG and the mono ones and only M-Spike is the true measure of the disease that we should be monitoring on. Also does the IgG number include the M-Spike number? Many thanks!

[Dr. Peter Voorhees]

Re: Serum Immunofixation Question

by Dr. Peter Voorhees on Sat Oct 22, 2011 4:57 am

In your wife's case, the total serum IgG includes normal IgG (made by non-cancerous plasma cells) and monoclonal IgG (The M spike made by cancerous plasma cells). The M spike measure is the most important thing to look at here. However, the M-spike measurement and the total IgG can be subject to significant lab variability. As such, I would keep a close watch on things to ensure that the disease is not progressing.

Take care!

Pete V.