I was going through the archives here recently and found this article about a drug called salubrinal.
Does anyone know if there are any salubrinal trials going on right now with myeloma patients? The article says that there are no trials going on, and the drug is not approved by the FDA, but the article was published a year ago.
Also, is there any way other than through a trial to get access to the drug to use it as a myeloma treatment?
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Re: Salubrinal
Ricardo,
There don't seem to be any ongoing clinical trials involving salubrinal ... at least not according to the database at ClinicalTrials.Gov.
This press release from Indiana University suggests that salubrinal is still in the very early stages of development. Moreover, the press release suggests that -- at least right now -- the intention is to develop salubrinal as a way to stimulate bone growth (rather than as a treatment for myeloma).
As far as getting access to the drug some way other than through a clinical trial, I doubt that you are going to find a (trustworthy) supplier able to provide you with pharmaceutical grade product.
There don't seem to be any ongoing clinical trials involving salubrinal ... at least not according to the database at ClinicalTrials.Gov.
This press release from Indiana University suggests that salubrinal is still in the very early stages of development. Moreover, the press release suggests that -- at least right now -- the intention is to develop salubrinal as a way to stimulate bone growth (rather than as a treatment for myeloma).
As far as getting access to the drug some way other than through a clinical trial, I doubt that you are going to find a (trustworthy) supplier able to provide you with pharmaceutical grade product.
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Boris Simkovich - Name: Boris Simkovich
Founder
The Myeloma Beacon
Re: Salubrinal
Anything new on this. It looked real promissing. I am surprised if there has not been some follow up unless it is so toxic that it can't even be put in a trial.
Ron
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: Salubrinal
It is being tested "on the side" as part of this trial,
"Study of High Dose Carfilzomib in Multiple Myeloma Patients Who Have Progressed On Standard Dose Carfilzomib", http://www.clinicaltrials.gov/ct2/show/NCT01775553
The study is being done at Mount Sinai. If you do a search for "salubrinal myeloma patent", you'll see that some people at Mount Sinai apparently have patent rights to salubrinal, or have applied for such rights, which would explain why the study is being done there.
In any case, it looks like it's being developed, but not necessarily on a really fast track.
"Study of High Dose Carfilzomib in Multiple Myeloma Patients Who Have Progressed On Standard Dose Carfilzomib", http://www.clinicaltrials.gov/ct2/show/NCT01775553
The study is being done at Mount Sinai. If you do a search for "salubrinal myeloma patent", you'll see that some people at Mount Sinai apparently have patent rights to salubrinal, or have applied for such rights, which would explain why the study is being done there.
In any case, it looks like it's being developed, but not necessarily on a really fast track.
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JimNY
Re: Salubrinal
You are right about the patent. See the link http://www.google.com/patents/US20120142634
Talk about a slow process, the patent was applied for back in 2008. It appears that it is not a patent on the drug itself but on the way it is administered - in conjunction with a proeteasome inhibiter such as Velcade. I didn't know that you could get a patent on a clinical application.
I read the clinical tiral brief and did not see when Salubrinal would be introduced. I am guessing it is later in the process when other drugs might be introduced for those that could not tollerate the higher levels of Carfilzomib.
Talk about a slow process, the patent was applied for back in 2008. It appears that it is not a patent on the drug itself but on the way it is administered - in conjunction with a proeteasome inhibiter such as Velcade. I didn't know that you could get a patent on a clinical application.
I read the clinical tiral brief and did not see when Salubrinal would be introduced. I am guessing it is later in the process when other drugs might be introduced for those that could not tollerate the higher levels of Carfilzomib.
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
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