[Eric Hofacket]

Re: RVD - Why does it stop working & how to stop that?

by Eric Hofacket on Mon Apr 06, 2015 10:20 am

Blair,

Overcoming drug resistance is something that is being pursued. I believe the researchers at Celgene would be ecstatic if they could find a way to overcome drug resistance with Revlimid, and, yes, I am sure the shareholders of Celgene would be ecstatic too.

[Ron Harvot]

Re: RVD - Why does it stop working & how to stop that?

by Ron Harvot on Mon Apr 06, 2015 2:26 pm

This is a follow on to Eric's post.

Here are three articles about the mechanisms for resistance to Velcade and Revlimid being discovered. The last one is a list of the top 10 discoveries of 2013. See items 6 and 7.
Also included is how the active ingreedent in Sucrets helps Velcade overcome resistence.

"Dyclonine, The Active Ingredient In Sucrets, May Enhance The Anti-Myeloma Activity Of Velcade," Sep 3, 2014

"Scientists Find A Protein That Causes Resistance To Velcade Treatment," The Myeloma Beacon, Sep 3, 2009

SV Rajkumar, "Top 10 Discoveries Of 2013 In Multiple Myeloma," The Myeloma Beacon, Jan 1, 2014

Ron

[blair77]

Re: RVD - Why does it stop working & how to stop that?

by blair77 on Tue Apr 07, 2015 5:18 am

@Eric - I hadn't thought of that! Since there's money involved not just lives I'm sure Celgene is pursuing it

[Ron Harvot]

Re: RVD - Why does it stop working & how to stop that?

by Ron Harvot on Tue Apr 07, 2015 9:47 am

Here is another article about unlocking resistance to Velcade and Revlimid"

"Keys to Unlocking Multiple Myeloma Resistance," Jan 5, 2012 (link to full text of article)

Excerpt:

In one study, Orlowski's research team found the following:

• Another approach involved the experimental IGF-1 blocker OSI-906, which killed drug resistant cells without harming healthy ones.
• Combining shRNA and OSI-906 killed even more myeloma cells.
• Revlimid resistance was overcome by blocking another pathway.
• In the other study, resistance to Revlimid was explored. Orlowski's lab had shown in earlier research that a protein CD44 plays a role in interfering with the drug, and its presence usually indicates a poor outlook for the patient.

The chemotherapy drug Vesanoid (all-trans-retinoic acid) can overcome Revlimid resistance and also decrease the level of CD44.

Researchers then combined Revlimid with an experimental drug FH535 to increase cell death in resistant multiple myeloma cell lines."

[blair77]

Re: RVD - Why does it stop working & how to stop that?

by blair77 on Tue Apr 07, 2015 11:53 pm

Sounds promising! So how do they go about blocking the pathways? Adding more drugs? Or is this still what needs to be discovered?