[JeffD]

RVD maintenance therapy - 21/28 days, or 28/28?

by JeffD on Sun Nov 05, 2017 8:23 am

So my hematologist was going to put me on Revlimid, Velcade, and dexamethasone (RVD), with 10 mg Revlimid, for maintenance following my autologous stem cell transplant. He wanted to have me on 28/28 day cycle (i.e., no break in the Revlimid dosing).

However, after consulting with the hematologist who performed my stem cell transplant, they decided to put me on 21 days on, 7 days off (21/28).

Is the 21/28 day approach more common? Is there any evidence that one is better than the other?

Thanks in advance,
Jeff

[dbsmithiii]

Re: RVD maintenance therapy - 21/28 days, or 28/28?

by dbsmithiii on Sun Nov 05, 2017 4:39 pm

Hi Jeff,

I don't know if it is any better, but I am on what appears to be the standard: 21 days on, 7 days off for Revlimid. I was not aware that there was a full-time regimen.

Doug

[Multibilly]

Re: RVD maintenance therapy - 21/28 days, or 28/28?

by Multibilly on Sun Nov 05, 2017 8:34 pm

See this thread for an earlier discussion on this topic:

https://myelomabeacon.org/forum/revlimid-maintenance-without-a-break-t2257.html

[Grizlump]

Re: RVD maintenance therapy - 21/28 days, or 28/28?

by Grizlump on Mon Nov 06, 2017 12:06 pm

Jeff,

It appears your doctor is using the same protocol for maintenance that mine used for my initial myeloma treatment regimen. Doesn't it seem strange that a patient would need identical treatment after a transplant? Am I missing something or do I smell a rat?

Charlie ( grouchy German)