[Beacon Staff]

Revlimid for high-risk smoldering myeloma (NEJM article)

by Beacon Staff on Thu Aug 01, 2013 11:34 am

The New England Journal of Medicine (NEJM) published yesterday an article summarizing the most recent results of the Spanish trial testing early treatment of high-risk smoldering myeloma with Revlimid and dexamethasone.

Celgene, the company that markets Revlimid, has published a press release highlighting some of the results published in the article. You can view the press release here:

https://myelomabeacon.org/pr/2013/08/01/revlimid-lenalidomide-smoldering-myeloma-new-england-journal-medicine/

The abstract of the article can be viewed here:

http://www.nejm.org/doi/full/10.1056/NEJMoa1300439

The results of the trial, and some of its potential implications, are discussed in this recent Beacon article that covers a presentation made by the lead author of the NEJM, Dr. Maria-Victoria Mateos, at the 2013 International Myeloma Workshop:

https://myelomabeacon.org/news/2013/04/26/early-treatment-for-high-risk-smoldering-myeloma-imw-2013/

A rather thorough discussion of the trial that led to the NEJM article, along with preliminary results, can be found in this older Beacon article:

https://myelomabeacon.org/news/2012/01/09/revlimid-lenalidomide-dexamethasone-combination-delays-disease-progression-in-patients-with-smoldering-multiple-myeloma-ash-2011/

which prompted this interview with Dr. Ola Landgren, an expert on smoldering myeloma, about the trial results:

https://myelomabeacon.org/news/2012/01/13/smoldering-myeloma-what-do-the-latest-research-findings-mean-a-discussion-with-dr-ola-landgren/

We will be writing a full review of the NEJM article for later publication here at The Beacon. For a list of all the Beacon's news and opinion articles related to smoldering myeloma, follow this link:

https://myelomabeacon.org/tag/smoldering-multiple-myeloma/

and for a list of forum discussions related to smoldering myeloma, follow this link:

http://bit.ly/14HIaAl

As always, feel free to post here any questions or comments you have in regard to all of this.

[Beacon Staff]

Re: Revlimid for high-risk smoldering myeloma (NEJM article)

by Beacon Staff on Fri Aug 02, 2013 5:46 pm

Just to complete this thread ... We've published our news article about the Spanish study. The article can be found here:

https://myelomabeacon.org/news/2013/08/02/revlimid-lenalidomide-dexamethasone-high-risk-smoldering-myeloma/

Also, here is a link to a presentation that one of the lead investigators of the trial, Dr. Maria-Victoria Mateos, did about the trial -- and its key results -- at the International Myeloma Workshop earlier this year.

https://myelomabeacon.org/docs/imw2013/slides/Mateos-ShouldWeTreatSmolderingMyeloma.pdf