My doctor switched me from Velcade to Kyprolis (carfilzomib) 59.4 mg.
Last result with Velcade.
(Started Nov 11, 2012, ended Jul 21, 2014)
IGA 70-400 MG/DL 60
IGG 700-1600 MG/DL 2008
IGM 40-230 MG/DL <13
KAPPA/LAMBDA FREE RATIO 0.26-1.65 11.58
KAPPA LIGHT CHAIN, FREE 3.30-19.40 MG/L 30.10
LAMBDA LIGHT CHAIN, FREE, SER/PLAS 5.71-26.30 MG/L 2.60
Last result with Kyprolis (carfilzomib) Oct 16, 2014
IGA 70-400 MG/DL 111
IGG 700-1600 MG/DL 1073
IGM 40-230 MG/DL 30
KAPPA/LAMBDA, FREE RATIO 0.26-1.65 1.74
KAPPA LIGHT CHAIN, FREE 3.30-19.40 MG/L 22.16
LAMBDA LIGHT CHAIN, FREE, SER/PLAS 5.71-26.30 MG/L 12.71
Success and Healing to Everyone
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Re: Latest lab results after switch to Kyprolis
Wow. That's an impressive improvement. Looks like all your numbers improved considerably and it also helped with immunoparesis (depression of your IgA and IgM).
What did your M-spike do in that same time?
Wishing you continued success with Kyprolis.
What did your M-spike do in that same time?
Wishing you continued success with Kyprolis.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Latest lab results after switch to Kyprolis
I agree with Multibilly. Nice results, powerdrivehp. Looks like your M-spike probably dropped to close to zero. Like Multibilly, I'm curious if you have your M-spike measurements.
Sounds like you were on a high dose of Kyprolis. How often did you get the infusion, and did you also take dex (and what dose)?
Also, before you were switched to the Kyprolis, were you taking just Velcade? Or Velcade plus dex? And what was your treatment before that?
Sorry for all the questions. Just trying to put your treatment into context.
Sounds like you were on a high dose of Kyprolis. How often did you get the infusion, and did you also take dex (and what dose)?
Also, before you were switched to the Kyprolis, were you taking just Velcade? Or Velcade plus dex? And what was your treatment before that?
Sorry for all the questions. Just trying to put your treatment into context.
Re: Latest lab results after switch to Kyprolis
M-Spike Jul 7, 2014
(with Velcade, dexamethasone (Decadron) 40 mg once a week, Revlimid 25 mg daily)
TOTAL PROTEIN 7.3
ALBUMIN, ELECTROPHORESIS 3.8
ALPHA 1 GLOB, SF, QN, EP 0.2
ALPHA 2 GLOB, SF, QN, EP 0.6
BETA GLOBULIN, ELECTROPHORESIS 0.9
GAMMA GLOBULIN, ELECTROPHORESIS 1.8
MONOCLONAL BAND OBSERVED, SERPLAS 1.3
INTERPRETATION REPORT (NOTE)
An abnormal monoclonal band is present in the gamma region.
M-Spike Oct 6, 2014
(with Kyprolis, dex 40 mg once a week, Revlimid 25 mg daily)
TOTAL PROTEIN 6.6
ALBUMIN, ELECTROPHORESIS 3.7
ALPHA 1 GLOB, SF, QN, EP 0.3
ALPHA 2 GLOB, SF, QN, EP 0.6
BETA GLOBULIN, ELECTROPHORESIS 1.0
GAMMA GLOBULIN, ELECTROPHORESIS 1.1
MONOCLONAL BAND OBSERVED, SERPLAS 0.4
INTERPRETATION REPORT (NOTE)
An abnormal monoclonal band is present in the gamma region.
Serum Protein Electrophoresis (PEP) is an analytical technique
that provides separation of serum protein into six fractions:
Albumin, Alpha-1, Alpha-2, Beta (Beta-1 and 2), and Gamma.
I admit sometimes I forget to take Revlimid or dex once in a while. Sometimes, if I have extra Revlimid pills, I will take them in my off week (usually 3 weeks treatment, 1 week off).
I receive Kyprolis 2 times per week ( Wed & Thu) for 3 weeks, 59.4 mg. Steroids - once a week, 10 tiny pills, 40 mg. Zometa - once a month.
(with Velcade, dexamethasone (Decadron) 40 mg once a week, Revlimid 25 mg daily)
TOTAL PROTEIN 7.3
ALBUMIN, ELECTROPHORESIS 3.8
ALPHA 1 GLOB, SF, QN, EP 0.2
ALPHA 2 GLOB, SF, QN, EP 0.6
BETA GLOBULIN, ELECTROPHORESIS 0.9
GAMMA GLOBULIN, ELECTROPHORESIS 1.8
MONOCLONAL BAND OBSERVED, SERPLAS 1.3
INTERPRETATION REPORT (NOTE)
An abnormal monoclonal band is present in the gamma region.
M-Spike Oct 6, 2014
(with Kyprolis, dex 40 mg once a week, Revlimid 25 mg daily)
TOTAL PROTEIN 6.6
ALBUMIN, ELECTROPHORESIS 3.7
ALPHA 1 GLOB, SF, QN, EP 0.3
ALPHA 2 GLOB, SF, QN, EP 0.6
BETA GLOBULIN, ELECTROPHORESIS 1.0
GAMMA GLOBULIN, ELECTROPHORESIS 1.1
MONOCLONAL BAND OBSERVED, SERPLAS 0.4
INTERPRETATION REPORT (NOTE)
An abnormal monoclonal band is present in the gamma region.
Serum Protein Electrophoresis (PEP) is an analytical technique
that provides separation of serum protein into six fractions:
Albumin, Alpha-1, Alpha-2, Beta (Beta-1 and 2), and Gamma.
I admit sometimes I forget to take Revlimid or dex once in a while. Sometimes, if I have extra Revlimid pills, I will take them in my off week (usually 3 weeks treatment, 1 week off).
I receive Kyprolis 2 times per week ( Wed & Thu) for 3 weeks, 59.4 mg. Steroids - once a week, 10 tiny pills, 40 mg. Zometa - once a month.
Re: Latest lab results after switch to Kyprolis
PowerDriveHP:
Thanks for the follow up. How have the side effects been for you when switching to high dose Kyprolis? I've read some of the interesting initial, positive results on this approach. It's obviously working in your case.
Thanks for the follow up. How have the side effects been for you when switching to high dose Kyprolis? I've read some of the interesting initial, positive results on this approach. It's obviously working in your case.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Latest lab results after switch to Kyprolis
Powerdrivehp,
I'd like to know how long you have been on the Kyprolis, dex, and Pomalyst and how are you doing with side effects? If you are having side effects - did they lessen with time?
My husband has just finished his first 3 week cycle of this and it has really kicked his butt - shortness of breath and fatigue.
I'd like to know how long you have been on the Kyprolis, dex, and Pomalyst and how are you doing with side effects? If you are having side effects - did they lessen with time?
My husband has just finished his first 3 week cycle of this and it has really kicked his butt - shortness of breath and fatigue.
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rumnting - Who do you know with myeloma?: husband
- When were you/they diagnosed?: 4/9/11
- Age at diagnosis: 54
Re: Latest lab results after switch to Kyprolis
Velcade was worst for me – caused me a lot of problems – mostly upset stomachs after the shots. There were times I had to go in and get re-hydrated for some reason.
With Kyprolis, I have not had any problems as of yet.
Well, I have the same thing, fatigue, and shortness of breath, but I made a choice to do a few things, like listening and dancing to my favorite music – great aerobic exercise, swimming 3 times a week, getting into positive motivation. In time he will conquer fatigue, but shortness of breath is harder to conquer. You might try a breathing device that exercises the lungs and build lung strength without running. Athletes use these all the time. They are relatively inexpensive. That is what I use.
I started Kyprolis in August, 2014 - 3 weeks, September, 2014 - 3 weeks, and October, 2014 - 2 weeks, with 1 week to go for a total of 3 weeks.
I would tell everyone on this board - run, don't walk to Kyprolis. Run and get it now.
I am not a doctor, so doctor's know best.
With Kyprolis, I have not had any problems as of yet.
Well, I have the same thing, fatigue, and shortness of breath, but I made a choice to do a few things, like listening and dancing to my favorite music – great aerobic exercise, swimming 3 times a week, getting into positive motivation. In time he will conquer fatigue, but shortness of breath is harder to conquer. You might try a breathing device that exercises the lungs and build lung strength without running. Athletes use these all the time. They are relatively inexpensive. That is what I use.
I started Kyprolis in August, 2014 - 3 weeks, September, 2014 - 3 weeks, and October, 2014 - 2 weeks, with 1 week to go for a total of 3 weeks.
I would tell everyone on this board - run, don't walk to Kyprolis. Run and get it now.
I am not a doctor, so doctor's know best.
Re: Latest lab results after switch to Kyprolis
Appreciate the follow up PowerDrive. It's always good to hear about side effects firsthand, rather than to read about a summary list in some clinical trial.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Latest lab results after switch to Kyprolis
Thanks Powerdrive for sharing your experience. My mother had horrible nerve pain from Velcade and rashes from Revlimid.
She is only on Kyprolis and dex now and finished her first cycle. She has no side effects from Kyprolis (apart from high blood sugar from dexas she is diabetic).
We are concerned that this combination alone might not be good enough for her to go into (temporary) remission.
She is only on Kyprolis and dex now and finished her first cycle. She has no side effects from Kyprolis (apart from high blood sugar from dexas she is diabetic).
We are concerned that this combination alone might not be good enough for her to go into (temporary) remission.
9 posts
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