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Response to ASCT data?
Following induction therapy with RVD my husband achieved A nCR ( m spike 0 with trace amounts on IFE and BMB) after 1 cycle he stayed at that level and then transplanted in November. At 60 days he is to be restaged and I am wondering where I can find data on his chance of being in complete response? I also was not aware that the transplant could make his disease worse not better, not sure if that's true?? Any ideas where to find info?
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blair77 - Who do you know with myeloma?: My husband
- When were you/they diagnosed?: April 2013
- Age at diagnosis: 43
Re: Response to ASCT data?
Hi Blair77,
Hope your husband is doing well! I'm sure it was tough having to undergo a SCT at the holidays.
Most people look to get their results around day +100 because the numbers fluxuate too much. Even after day +100 your M-spike can continue to drop - Ej's didn't settle out until several months later, around day +160, I think. I've not heard of anyone saying a SCT can make your myeloma worse, but there have been several people who have posted that their SCT didn't work, most notably Pat Killingsworth who writes a column for the Beacon. But I think this is relatively rare, or at least not the norm.
Lyn
Hope your husband is doing well! I'm sure it was tough having to undergo a SCT at the holidays.
Most people look to get their results around day +100 because the numbers fluxuate too much. Even after day +100 your M-spike can continue to drop - Ej's didn't settle out until several months later, around day +160, I think. I've not heard of anyone saying a SCT can make your myeloma worse, but there have been several people who have posted that their SCT didn't work, most notably Pat Killingsworth who writes a column for the Beacon. But I think this is relatively rare, or at least not the norm.
Lyn
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Christa's Mom - Name: Christa's Mom
- Who do you know with myeloma?: Husband
- When were you/they diagnosed?: September, 2010
- Age at diagnosis: 53
Re: Response to ASCT data?
Hello Blair77,
In general a stem cell transplant does not make a patient's myeloma worse. There is really no discussion or reports on this topic in the literature. However, if a patient does not respond to a transplant that may select for more aggresive and resistant myeloma. This would make it appear that transplantation "worsens " the disease. I do not mean to discount any patient's experience with transplant ( good or bad) but simply to relay the overall experience of the transplant community. I have cared for patients who had no response to transplantation and others who have had very long remissions. On balance though, stem cell transplantation benefits the majority of multiple myeloma patients who are candidates for the procedure.
In general a stem cell transplant does not make a patient's myeloma worse. There is really no discussion or reports on this topic in the literature. However, if a patient does not respond to a transplant that may select for more aggresive and resistant myeloma. This would make it appear that transplantation "worsens " the disease. I do not mean to discount any patient's experience with transplant ( good or bad) but simply to relay the overall experience of the transplant community. I have cared for patients who had no response to transplantation and others who have had very long remissions. On balance though, stem cell transplantation benefits the majority of multiple myeloma patients who are candidates for the procedure.
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Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
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