Response after 3 cycles of PAD
After no luck with REV-DEX and a complication with intestinal stroke, caused by occlusion, and the removal surgery (possibly caused by the first therapy)
Her disease is a high risk multiple myeloma with 1q and t414 ISS2 IgG lambda with no bone litic lesion, no renal failure , only moderate anaemia in the crab symptom.
my mother‘s disease seems to respond after 3 cycles of PAD.
After the revaluation of a third cycle of pad my mother achieved a VGPR because her M spike has gone down from 41g/l to 1.39g/l,hemoglobin now is 10.5
The therapy was well tolerated, except for moderate asthenia, stomach pain and constipation, as well as a little pain in the soles of the feet (a sticky feeling that is alleviated if she walks barefoot or soaks her feet in cold water - the doctor is uncertain if this feeling is neuropathy or palmar-plantar erythrodysesthesia – what do you think it could be?)
Before mobilization with cyclophosphamide for the stem cell collection, she has to do some examinations: ECG chest X-ray respiratory function tests and ultrasound scan abdomen
I think this is a good result, right?
I would like to hear your opinion about how the cure is doing
I appreciate your help
Forums
6 posts
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Re: Response after 3 cycles of PAD before ASCT
Hello Manuel,
This is a good response but not a VGPR. The definition of a VGPR is for the m-spike to fall by 90% or more. Your mother's m-spike has fallen by 66%. This is a partial remission (anything more than 50% and less than 90%). The question now is will she be able to have a VGPR or CR after her stem cell transplantation.
This is a good response but not a VGPR. The definition of a VGPR is for the m-spike to fall by 90% or more. Your mother's m-spike has fallen by 66%. This is a partial remission (anything more than 50% and less than 90%). The question now is will she be able to have a VGPR or CR after her stem cell transplantation.
-
Dr. Edward Libby - Name: Edward Libby, M.D.
Beacon Medical Advisor
Re: Response after 3 cycles of PAD before ASCT
thank you for your reply Dr.Edward Libby i'm hoping i'm not clear in my post,or you
read wrong my post.
Maybe you read 41g/l to 13,9 g/l this is 66 percent but is 1,39 g/L is much then 90 percent right?
If i make a mistake i'm apologize in advance with you,i'm only try to understand
today is a good day for my mother and me all the analysis doing wheel
the heart is the same before the PAD first cycle traditional doxorubicine
second and third cycle pegylated liposomial doxorubicine 30 Mgm2(Ejection fraction>60%)
ultrasound abdomen and chest rx is negative as wheel
only one bad news my mother have to install a central venous catheter,because the physician says they can somministrate Endoxan into her arms veins,
but they doubt after this round of chemo they are able to use again her arms veins
for colletting and reinfusing stem cell.
i'm hoping and praying for a CR.
An improvement in the deep of resposne is possible even after the cyclophospamide?
thank you this forum is really a beacon for us caregivers and patient,
really is not a circumstance phrase but really a precious help
read wrong my post.
Maybe you read 41g/l to 13,9 g/l this is 66 percent but is 1,39 g/L is much then 90 percent right?
If i make a mistake i'm apologize in advance with you,i'm only try to understand
today is a good day for my mother and me all the analysis doing wheel
the heart is the same before the PAD first cycle traditional doxorubicine
second and third cycle pegylated liposomial doxorubicine 30 Mgm2(Ejection fraction>60%)
ultrasound abdomen and chest rx is negative as wheel
only one bad news my mother have to install a central venous catheter,because the physician says they can somministrate Endoxan into her arms veins,
but they doubt after this round of chemo they are able to use again her arms veins
for colletting and reinfusing stem cell.
i'm hoping and praying for a CR.
An improvement in the deep of resposne is possible even after the cyclophospamide?
thank you this forum is really a beacon for us caregivers and patient,
really is not a circumstance phrase but really a precious help
Re: Response after 3 cycles of PAD before ASCT
hi,
in the meantime my mother underwent high dose cyclophosphamide
it was well tolerated.
today is the first day of leukapheresis, they were unable to collect enough stem cells
for the double asct "only" 7,8 milions
tomorrow they will try again to collect stem cell, target 12 milions.
I have a question: is it important to do bone marrow biopsy before collecting the cells?
Is the drop of the M spike from 41g/L to 1,3g/L a secure marker to collect stem cell without residual malignancy?
thank you for reading
in the meantime my mother underwent high dose cyclophosphamide
it was well tolerated.
today is the first day of leukapheresis, they were unable to collect enough stem cells
for the double asct "only" 7,8 milions
tomorrow they will try again to collect stem cell, target 12 milions.
I have a question: is it important to do bone marrow biopsy before collecting the cells?
Is the drop of the M spike from 41g/L to 1,3g/L a secure marker to collect stem cell without residual malignancy?
thank you for reading
Re: Response after 3 cycles of PAD before ASCT
On the second day of leukapheresis, the cell count reached 11.5 milion cells.
Unfortunally,like physician say to us before the chemo
my mother lost most of her hair,i'm hoping all this suffering, make at least a few years of control on her diesase.
I'm still uncertain about the importance of doing a biopsy (BMB) before collecting the cells. Can anybody give me an idea?
Unfortunally,like physician say to us before the chemo
my mother lost most of her hair,i'm hoping all this suffering, make at least a few years of control on her diesase.
I'm still uncertain about the importance of doing a biopsy (BMB) before collecting the cells. Can anybody give me an idea?
Re: Response after 3 cycles of PAD before ASCT
After the last evaluation, the M component went from 1,3 to N/Q.
The g-lambda are still measurable, in small quantity, through electroforesis.
Doctors are saying this is a VGPR, close to a complete response.
The last FISH
(after Rev Dex But before PAD at that time BMB show 60% plasmacell in the bone marrow) doesn't show T4/14 altered cells, is this possible?
Is this a good sign? Could it give us hope for a longer-lasting remission?
After three cycles of PAD and high-dose Cyclophosphamide, the plasma cells in the bone marrow have gone down from 60% in the previous evaluation to 1%.
As far as 1q, I was told that it doesn't show up with the technology used in the hospital where she is being cured.
The previous FISH was done through Eloquent trials so the samples were sent abroad.
I am really happy about these results and hope that, with the transplant, we can reach a complete response.
On the other hand, the ECG showed a reduction in ejection fraction from 62% to 53%.
The cardiologist reassured me that anything above 50% is ok.
To prepare for the transplant, they will use melphalan in 140mg/mq doses.
it's a safe dosage in the specific case of my mother 71 year's old?
At the first time i'm glad they use this dosage,
but i'm worried about worsening of the heart condition,
after the last ECG show the reduction of the ejection fraction
We are waiting for the call from the hospital for the recovery, I hope everything will be okay.
The g-lambda are still measurable, in small quantity, through electroforesis.
Doctors are saying this is a VGPR, close to a complete response.
The last FISH
(after Rev Dex But before PAD at that time BMB show 60% plasmacell in the bone marrow) doesn't show T4/14 altered cells, is this possible?
Is this a good sign? Could it give us hope for a longer-lasting remission?
After three cycles of PAD and high-dose Cyclophosphamide, the plasma cells in the bone marrow have gone down from 60% in the previous evaluation to 1%.
As far as 1q, I was told that it doesn't show up with the technology used in the hospital where she is being cured.
The previous FISH was done through Eloquent trials so the samples were sent abroad.
I am really happy about these results and hope that, with the transplant, we can reach a complete response.
On the other hand, the ECG showed a reduction in ejection fraction from 62% to 53%.
The cardiologist reassured me that anything above 50% is ok.
To prepare for the transplant, they will use melphalan in 140mg/mq doses.
it's a safe dosage in the specific case of my mother 71 year's old?
At the first time i'm glad they use this dosage,
but i'm worried about worsening of the heart condition,
after the last ECG show the reduction of the ejection fraction
We are waiting for the call from the hospital for the recovery, I hope everything will be okay.
6 posts
• Page 1 of 1
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