[shyam]

How to reduce kappa-lambda free light chain ratio?

by shyam on Mon Jun 15, 2015 3:08 am

Hi

My dad is a multiple myeloma patient since July 2014.

Now, in a recent biochemistry test, the free kappa (serum) is 722.1 mg/l and free lambda (serum) is 10.58 mg/l. Kappa / lambda ratio is 68.25.

I just want to know how can we reduce this ratio?

[Ron Harvot]

Re: How to reduce kappa-lambda free light chain ratio?

by Ron Harvot on Mon Jun 15, 2015 3:35 pm

Since you said your dad is a patient, that implies he has an oncologist and hopefully a multiple myeloma oncology specialist. He undoubtedly has a course of treatment that he is following. The initial treatment can include various chemo drugs including novel agents, induction followed by an autologous stem cell transplant (ASCT), or a combination that may or may not be followed by maintenance. The sFLC test will show if the treatment is working. If not, the treatment will be adjusted.

Ron

[JimNY]

Re: How to reduce kappa-lambda free light chain ratio?

by JimNY on Mon Jun 15, 2015 6:06 pm

Hi shyam,

Just to follow up briefly on what Ron wrote, the way to get your father's light chain numbers under control is to effectively treat his myeloma. For someone with multiple myeloma, free light chain numbers that are persistently out of the normal range are a sign that the disease is active.

If someone has smoldering multiple myeloma and has never been treated, then out-of-range free light chain levels that are not too high may be acceptable if the numbers are stable. Theoretically, this also could happen to a multiple myeloma patient who has been treated, has active disease, and also has stable free light chain numbers.

If the numbers are high and rising, however, then treatment is really the only way to get them back under control.

Good luck,

Jim

[Joy Majumdar]

Re: How to reduce kappa-lambda free light chain ratio?

by Joy Majumdar on Sat Jun 27, 2015 12:28 pm

Thanks Jim, its valuable informaton for me, I am looking for answers about my mom, after 3 months of TD course, her Kappa increasing still, but M band goes down, Hb is still very low. Is it normal? or need to change the dose or regimen?

- Joy