[ciro]

Reactive marrow change on MRI - what's it mean?

by ciro on Wed Oct 29, 2014 4:46 pm

I recently had an MRI of my humerus, which did not show any lytic lesions, but there was a "mild T1 hypointensity and T2 hyperintensity in the proximal humerus, stopping at the humeral head" which the radiologist read as "reactive marrow change".

Has anyone else run into this? What is the significance of this finding?

The MRI of my spine was okay.

I am 63 years old and was diagnosed with smoldering multiple myeloma in Oct 2013, on the basis of 5-10% plasma cells in my bone marrow. I have a biclonal gammopathy, IgA lambda and IgG kappa, with the IgA lambda predominant.

My paraprotein level has increased from 0.28 g/dL in August 2013 to 0.48 g/dL in August 2014.

My lambda light chains are elevated and vacillating with a high of 89 mg/L in June 2014 and a low of 67.3 mg/L in August 2014.

My kappa light chains are in the normal range (9.9 mg/L in June 2014 and 8.5 mg/L in August 2014.)

The lambda/kappa ratio in June was 9.04 and in August was 7.9.

I am otherwise healthy, aside from mild Hasimoto's thyroiditis, which has been stable with thyroid hormone replacement. I do not have any CRAB symptoms. The MRI of my humerus was done because of some questionable lesions on my skeletal scan in this area.