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proteasome
I may be asking a bit much, but can anyone explain the function of proeasome and why we want to inhibit them by taking proteasome inhibitors?
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mrsv118 - Name: Kate
- Who do you know with myeloma?: ME
- When were you/they diagnosed?: 7/19/12
- Age at diagnosis: 48
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: proteasome
thanks multibilly,
I still don't think i get it. It says that:
Specifically, the 26S proteasome is a multienzyme protease that degrades misfolded or redundant proteins;( isnt that what we want?) conversely, blockade of the proteasomal degradation pathways results in accumulation of unwanted proteins and cell death.
I need proteasome pathway for dummies.
I still don't think i get it. It says that:
Specifically, the 26S proteasome is a multienzyme protease that degrades misfolded or redundant proteins;( isnt that what we want?) conversely, blockade of the proteasomal degradation pathways results in accumulation of unwanted proteins and cell death.
I need proteasome pathway for dummies.
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mrsv118 - Name: Kate
- Who do you know with myeloma?: ME
- When were you/they diagnosed?: 7/19/12
- Age at diagnosis: 48
Re: proteasome
Yes, that reference is a bit dense, eh? I am absolutely a newbie to all this, but you will find many web references if you just google "proteasome inhibitor myeloma", including the following:
http://jnci.oxfordjournals.org/content/95/12/845.full
I am personally trying to find a way to avoid the use of Velcade and the potential for neuropathy that may accompany its usage. While I consider myself a stoic individual (and my wife would agree that I am stoic), persistent pain is not something I want to potentially deal with. I understand that the use of subcutaneous injections of Velcade may reduce the risk of neuropathy, but I am concerned nonetheless.
http://jnci.oxfordjournals.org/content/95/12/845.full
I am personally trying to find a way to avoid the use of Velcade and the potential for neuropathy that may accompany its usage. While I consider myself a stoic individual (and my wife would agree that I am stoic), persistent pain is not something I want to potentially deal with. I understand that the use of subcutaneous injections of Velcade may reduce the risk of neuropathy, but I am concerned nonetheless.
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: proteasome
Try this it explains how Velcade works. It is a proteasome inhibitor so is Carfiilzomib.
https://myelomabeacon.org/resources/2008/10/15/Velcade/
Ron
https://myelomabeacon.org/resources/2008/10/15/Velcade/
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: proteasome
Insofar a PN is concerned, it is not something a majority of patients on Velcade experience. Some do and some have a significant reaction. Others like me have never had an issue with Velcade. The SubQ (injection as opposed to infusion) has greatly reduced the incidence and intensity of PN. I have been on Velcade for over 3 1/2 years. Initially it was once a week but it is now once every two weeks as I am in a maintenance mode.
Ron
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: proteasome
Ron, thank you!
That article from the Oxford journal did the trick!
I couldn't figure out why you would want to block something that regulates cell death. Now I see that myeloma cells work a bit differently and that allowing them to build up proteins is actually a better way to kill them. Does that sound right to you?
I just started a Carfilzamib, Lanalidomide and Dex protocol.
Thanks again,
Kate
That article from the Oxford journal did the trick!
I couldn't figure out why you would want to block something that regulates cell death. Now I see that myeloma cells work a bit differently and that allowing them to build up proteins is actually a better way to kill them. Does that sound right to you?
I just started a Carfilzamib, Lanalidomide and Dex protocol.
Thanks again,
Kate
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mrsv118 - Name: Kate
- Who do you know with myeloma?: ME
- When were you/they diagnosed?: 7/19/12
- Age at diagnosis: 48
Re: proteasome
Hi Kate -
You are correct, as far as I understand it. Myeloma cells tend to produce more misfolded proteins than normal cells. The proteosome degrades these proteins before they can build up enough to be toxic to the cell. If you limit proteosome activity in these cells, then the misfolded proteins will build up and kill the cell. Normal cells don't produce anywhere near as many misfolded proteins and can handle some lowering of proteosome activity without dying. (At least, that's how I read this stuff.)
You are correct, as far as I understand it. Myeloma cells tend to produce more misfolded proteins than normal cells. The proteosome degrades these proteins before they can build up enough to be toxic to the cell. If you limit proteosome activity in these cells, then the misfolded proteins will build up and kill the cell. Normal cells don't produce anywhere near as many misfolded proteins and can handle some lowering of proteosome activity without dying. (At least, that's how I read this stuff.)
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Anonymous
Re: proteasome
thanks for the great explanation! 
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mrsv118 - Name: Kate
- Who do you know with myeloma?: ME
- When were you/they diagnosed?: 7/19/12
- Age at diagnosis: 48
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