[torimooney]

polyclonal cells significance in determing level of remissio

by torimooney on Sun Dec 08, 2013 4:32 pm

I received the results of my bone marrow biopsy requested by my multiple myeloma specialist to determine what level of remission I‘ve achieved. I’ve had a 0 m spike and normal K/L ratio for the past 6 months. IGG etc. have been slightly below normal. My bone marrow shows “no plasma cell dyscrasia” and my Fish shows “no monoclonal B cells or aberrant T cell phenotypes”. I know that is great. However it shows “very small percentage of polyclonal plasma cells”. I‘ve researched articles and I am left to understand for stringent complete remission it must show no clonal cells. I am assuming that means both mono and polyclonal cells. I read a post by a multiple myeloma patient who said stringent remission means no monoclonal (not polyclonal) cells. I will see my oncologist is 2 months but until then can someone shed some light on this subject. Does having polyclonal cells have significance? Any input on this subject will be greatly appreciated.

[Multibilly]

Re: polyclonal cells significance in determing level of remi

by Multibilly on Sun Dec 08, 2013 6:09 pm

See Dr. Voorhees' comment on the subject here.

https://myelomabeacon.org/forum/remission-what-does-it-mean-t1554.html

[torimooney]

Re: polyclonal cells significance in determing level of remi

by torimooney on Mon Dec 09, 2013 12:26 pm

Thanks Multibilly, I knew I had read something about polyclonal cells/ as it relates to remission. But the other articles I had read referred to no clonal cells present so I was confused. I think it's time for me to CELEBRATE.

[Dr. Peter Voorhees]

Re: polyclonal cells significance in determing level of remi

by Dr. Peter Voorhees on Mon Dec 09, 2013 11:13 pm

Polyclonal plasma cells are indeed good! Congrats on a terrific response to treatment. Keep up the great work!

Pete V.