Attached is a recent article that looks like very promissing research. The Ohio State study shows the apparent ability to modify a patients T cells (immune system) to target the CS1 molecule that is found in 95% of multiple myeloma patients. This targeting would ulitmately destroy the multiple myeloma cells.
http://cancer.osu.edu/mediaroom/releases/Pages/A-Form-of-Immune-Therapy-Might-be-Effective-for-Multiple-Myeloma.aspx
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: Ohio State Study - T Cells modified to target CS1 molecu
Thanks for posting this article about modified 'T' cells, Ron. It sounds like they got really good initial results in lab studies. There is so much good research ongoing, that I am getting much more hopeful about the future of myeloma treatments!
I had previously thought that modified cells had to be individualized from one person to the next, but in this study it looks as if a modified cell line is being produced that could be used in more than the original person. Did you also get that impression from this study?
I had previously thought that modified cells had to be individualized from one person to the next, but in this study it looks as if a modified cell line is being produced that could be used in more than the original person. Did you also get that impression from this study?
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Nancy Shamanna - Name: Nancy Shamanna
- Who do you know with myeloma?: Self and others too
- When were you/they diagnosed?: July 2009
Re: Ohio State Study - T Cells modified to target CS1 molecu
Nancy,
I got the same impression you did, which makes this more exciting. It will probably be years away but I love the idea of harnessing the body's own immune system to identify and attack the multiple myeloma cells. That type of treatment IMO will be much closer to "cure" than any drug or ASCT therapy that we have now.
Ron
I got the same impression you did, which makes this more exciting. It will probably be years away but I love the idea of harnessing the body's own immune system to identify and attack the multiple myeloma cells. That type of treatment IMO will be much closer to "cure" than any drug or ASCT therapy that we have now.
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: Ohio State Study - T Cells modified to target CS1 molecu
With all the research coming along for a possible cure (t-cells, measles vaccine, etc.), if one ever comes to fruition, I wonder how the drug companies will react since drugs like Revlimid and Velcade make huge profits for them. I hate to believe in conspiracies but it makes me wonder if a cure ever came along, would the drug companies try to stop them from being used?
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DallasGG - Name: Kent
- Who do you know with myeloma?: myself
- When were you/they diagnosed?: 6/20/2013
- Age at diagnosis: 56
Re: Ohio State Study - T Cells modified to target CS1 molecu
Kent,
I hear you, but I guess I am of the belief that drug progress and cure would trump drug companies short term profits. New drugs come about all the time that often make old drugs / older technology obsolete. A cure will likely be the result of new drug therapy and new winners would come out of it. Also any attempt to suppress progress would be met with a political and social outcry and possibly criminal prosecution.
So I am positive about it and believe that progress wins out in the long run. I just hope we all can last the long run to be there to experience it.
Ron
I hear you, but I guess I am of the belief that drug progress and cure would trump drug companies short term profits. New drugs come about all the time that often make old drugs / older technology obsolete. A cure will likely be the result of new drug therapy and new winners would come out of it. Also any attempt to suppress progress would be met with a political and social outcry and possibly criminal prosecution.
So I am positive about it and believe that progress wins out in the long run. I just hope we all can last the long run to be there to experience it.
Ron
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Ron Harvot - Name: Ron Harvot
- Who do you know with myeloma?: Myself
- When were you/they diagnosed?: Feb 2009
- Age at diagnosis: 56
Re: Ohio State Study - T Cells modified to target CS1 molecu
Hi,
Interesting discussion.
Have you seen the study/trials at Mayo Clinic using the measles vaccine? It to shows promise but is only at the phase 1 trail. Not sure how to post the link to the information / report on this but one of two people who had the injection is in remission(?) after almost a year after getting the shot of Very high dose of measles vaccine, if you Google it you can get the info.
Mike
Interesting discussion.
Have you seen the study/trials at Mayo Clinic using the measles vaccine? It to shows promise but is only at the phase 1 trail. Not sure how to post the link to the information / report on this but one of two people who had the injection is in remission(?) after almost a year after getting the shot of Very high dose of measles vaccine, if you Google it you can get the info.
Mike
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mikew
Re: Ohio State Study - T Cells modified to target CS1 molecu
Hi Mike,
Thanks for your posting.
There is a separate discussion thread here in the forum devoted to the Mayo research you've mentioned. You can find it here:
"Reengineered measles virus fights multiple myeloma"
The thread includes links related to the study, including a press release, the journal article where the research was reported, etc.
Thanks for your posting.
There is a separate discussion thread here in the forum devoted to the Mayo research you've mentioned. You can find it here:
"Reengineered measles virus fights multiple myeloma"
The thread includes links related to the study, including a press release, the journal article where the research was reported, etc.
7 posts
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