[Cheryl G]

NovaSOL curcumin

by Cheryl G on Tue Jan 28, 2014 9:51 am

This may be of interest to some here:

http://www.ingredientsnetwork.com/News/Show/114/Frutarom_publishes_curcumin_bioavailability_study, "Frutarom publishes curcumin bioavailability study"

The article (or press release, I can't tell) discusses a new form of curcumin, called NovaSOL curcumin, that supposedly has higher biovailability than other curcumin formulations.

Biovailability is measured by the "area under the curve" metric (AUC). Here are the key results:

"Based on comparisons of plasma AUC, the study is said to demonstrate significant differences between the three curcumin formulations with total AUC as follows: native curcumin 66 +/- 116 nmol/L×h, curcumin micronisate 583 +/- 289 nmol/L×h, and curcumin micelle [NovaSOL curcumin] 12148 +/- 4547 nmol/L×h. The numbers show a 185-fold higher AUC, demonstrating conclusively the superior bioavailability of the curcumin micelle compared to native curcumin."

This press release,

http://www.prnewswire.com/news-releases/frutarom-will-market-novasol-curcumin-231883461.html, "Frutarom Will Market NovaSOL® Curcumin"

from last November says that NovaSOL curcumin, the formulation of curcumin discussed in the article above, will be marketed by the company Frutarom. However, I can't find anything suggesting NovaSOL curcumin is actually available anyplace.

[Multibilly]

Re: NovaSOL curcumin

by Multibilly on Tue Jan 28, 2014 10:23 am

Be careful as to what you may read into this. I am currently taking C3 Reduct, which was touted as having high bioavailability as well. But even if you do believe the bioavailabity data these companies are putting out (I am always skeptical of the supplement company claims), there is more to consider than just bioavailabiliy itself.

Don't get me wrong. There is a lot of evidence out there that suggests that curcumin can indeed be beneficial to multiple myeloma patients ... it's just more complex than one may think and more studies really need to be done to figure out just what is the best formulation for specifically treating myeloma.

[dnalex]

Re: NovaSOL curcumin

by dnalex on Tue Jan 28, 2014 6:43 pm

Multibilly,

This is actually the only published study I could find with curcumin and myeloma:

http://www.ncbi.nlm.nih.gov/pubmed/22473809/?i=8&from=curcumin%20myeloma

Do you know of others? The rest talks about how curcumin can sensitize myeloma cells to chemo agents in vitro.

Thanks.

Moderator's note:

The study that dnalex mentions above is discussed at length in this Beacon news article.

Also, the curcumin topic page at The Beacon,

https://myelomabeacon.org/tag/curcumin/

has other curcumin-related news relevant to multiple myeloma.

[Multibilly]

Re: NovaSOL curcumin

by Multibilly on Tue Jan 28, 2014 7:16 pm

Here are some links I've saved over the past year.

http://www.demandcurestoday.org/cancer-research/study-of-water-soluable-curcumine-in-advanced-malignancies

http://lpi.oregonstate.edu/infocenter/phytochemicals/curcumin/

http://clincancerres.aacrjournals.org/content/15/4/1123.full.pdf

http://umexpert.um.edu.my/file/publication/00004377_91057.pdf

http://www.sciedu.ca/journal/index.php/jhm/article/view/1997

Curcumin is also one of the components of TAB's supplement regiment mentioned here in the comments section of Steve M's recent article:

https://myelomabeacon.org/headline/2014/01/16/mohrs-myeloma-musings-from-watch-and-wait-to-uncertain-certainty/

You will find both detractors and proponents of supplements on this site.

I am lucky in that I’m smoldering and therefore asymptomatic. I personally believe that those with MGUS or SMM have a unique opportunity to experiment exclusively with diet and supplements to curb the disease’s progression. However, if you are symptomatic and have developed CRAB symptoms or have a very high plasma cell burden, I am in no way advocating alternative non-chemo therapies as a substitute for chemo. I believe there is a tipping point where alternative methods just won’t cut it and one has to consider various chemo treatments to treat this disease.

Anyone considering supplementation should first clear it with their oncologist, especially if you are on chemo. These supplements can potentially have powerful interactions with one’s cells and chemo agents.

[dnalex]

Re: NovaSOL curcumin

by dnalex on Tue Jan 28, 2014 9:17 pm

Thank you!

Other than that one paper, I have not found much concrete evidence. There are a lot of suggestions, but not much more to go by.

That is not to say that I am against using curcumin. My mom is in fact taking curcumin supplements daily, and I wouldn't have it any other way.

Hopefully, there will be more good news forthcoming.

[Multibilly]

Re: NovaSOL curcumin

by Multibilly on Tue Jan 28, 2014 9:54 pm

Yep. Note that it took about two years before TAB saw his immunoglobulins turn after starting his supplement plan. So, it's not like one is going to start taking curcumin and see the benefits right away....at least that is the expectation I have set for myself.