Is it rare for a FISH test to diagnose myeloma with normal cytogenetic findings? Especially when it states "insuffient speciman" for chromosomes x, y, z? Should my mom have another bone biopsy? Her doctor doesn't seem to think it's necessary for further testing.
Thanks.
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Re: Is it rare to have normal cytogenetics at diagnosis?
Actually, it's the norm to have good cytogenetics with multiple myeloma (that is, to not have the genetic mutations typically associated with worse outcomes for multiple myeloma).
https://myelomabeacon.org/news/2013/06/19/translocation-11-14-impact-transplant-outcomes-myeloma/
"....The researchers retrospectively analyzed the records of 993 multiple myeloma patients who underwent an autologous stem cell transplant at M.D. Anderson between 2000 and 2010.
They divided the patients into three groups based on their chromosomal profiles: 869 of the patients had chromosomal profiles that were considered normal, 27 had translocation t(11;14), and 97 had what the researchers defined as high-risk chromosomal abnormalities (but without the t(11;14) abnormality). Nine patients of the 27 patients with t(11;14) had concurrent high-risk chromosomal abnormalities".
https://myelomabeacon.org/news/2013/06/19/translocation-11-14-impact-transplant-outcomes-myeloma/
"....The researchers retrospectively analyzed the records of 993 multiple myeloma patients who underwent an autologous stem cell transplant at M.D. Anderson between 2000 and 2010.
They divided the patients into three groups based on their chromosomal profiles: 869 of the patients had chromosomal profiles that were considered normal, 27 had translocation t(11;14), and 97 had what the researchers defined as high-risk chromosomal abnormalities (but without the t(11;14) abnormality). Nine patients of the 27 patients with t(11;14) had concurrent high-risk chromosomal abnormalities".
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Multibilly - Name: Multibilly
- Who do you know with myeloma?: Me
- When were you/they diagnosed?: Smoldering, Nov, 2012
Re: Is it rare to have normal cytogenetics at diagnosis?
I am a little confused but in your mom’s case it seems there was not enough myeloma to complete at least some of the FISH analysis? Not a bad place to be in.
It seems like your mom’s FISH testing experience is similar to mine. The first bone marrow biopsy I had where a FISH was done was some time after my Velcade treatment had started. There were insufficient myeloma cells to do this test. This is what I would call a high quality problem. A biopsy I had done earlier this year showed 5% cancerous cells and a FISH was done that showed normal cytogenetics, which was good news.
Seeing that bone marrow biopsies are not that much fun to go through, it would make sense not to do another for the purposes of getting FISH results until there is sufficient reason to believe there would be enough myeloma to complete the test.
It seems like your mom’s FISH testing experience is similar to mine. The first bone marrow biopsy I had where a FISH was done was some time after my Velcade treatment had started. There were insufficient myeloma cells to do this test. This is what I would call a high quality problem. A biopsy I had done earlier this year showed 5% cancerous cells and a FISH was done that showed normal cytogenetics, which was good news.
Seeing that bone marrow biopsies are not that much fun to go through, it would make sense not to do another for the purposes of getting FISH results until there is sufficient reason to believe there would be enough myeloma to complete the test.
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Eric Hofacket - Name: Eric H
- When were you/they diagnosed?: 01 April 2011
- Age at diagnosis: 44
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