At diagnosis my husband's bone marrow biopsy (BMB) was tested with FISH which showed no cytogenetic abnormalities related to myeloma. However, post ASCT he has no M spike, less then 5% plasma with a polyclonal pattern, and the only test they did on his bone marrow was a karyotype.
Why would they have not performed the FISH?
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blair77 - Who do you know with myeloma?: My husband
- When were you/they diagnosed?: April 2013
- Age at diagnosis: 43
No FISH test after stem cell transplant - why?
Hello 
Given the very good bone marrow results, in addition to the lack of known myeloma cytogenetic abnormalities at diagnosis, I don't think there was compelling reason to do FISH again.
Bone marrow cells comprising of about 5% polyclonal plasma cells means that there are very few (if any?) myeloma cells in that particular sample, which is a very good thing.
I suspect that eventually, your doctor will add minimal residual disease (MRD) to the panel of things to be tested in bone marrow.
Given the very good bone marrow results, in addition to the lack of known myeloma cytogenetic abnormalities at diagnosis, I don't think there was compelling reason to do FISH again.
Bone marrow cells comprising of about 5% polyclonal plasma cells means that there are very few (if any?) myeloma cells in that particular sample, which is a very good thing.
I suspect that eventually, your doctor will add minimal residual disease (MRD) to the panel of things to be tested in bone marrow.
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dnalex - Name: Alex N.
- Who do you know with myeloma?: mother
- When were you/they diagnosed?: 2007
- Age at diagnosis: 56
Re: No FISH test after stem cell transplant - why?
You cannot do a FISH cytogenetic test if there are no myeloma cells.
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goldmine848 - Name: Andrew
- When were you/they diagnosed?: June 2013
- Age at diagnosis: 60
Re: No FISH test after stem cell transplant - why?
They ordered a FISH test on my bone marrow biopsy after my SCT, I had not had one yet. As Dr. Andrew said, the could not do it, there were not any or enough myeloma cells in the sample to perform the test. I would call this a high qulaity problem 
. On my last biopsy a few months ago there were enough cells for FISH and I did get results which were pretty good, no high risk abnormalties were found.
. On my last biopsy a few months ago there were enough cells for FISH and I did get results which were pretty good, no high risk abnormalties were found.-
Eric Hofacket - Name: Eric H
- When were you/they diagnosed?: 01 April 2011
- Age at diagnosis: 44
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