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Myeloma Subtype
What is being referred to when they reference a persons multiple myeloma subtype?
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blair77 - Who do you know with myeloma?: My husband
- When were you/they diagnosed?: April 2013
- Age at diagnosis: 43
Re: Myeloma Subtype
Good morning. I'm not sure what the context is for your question. There are general classifications and then there are molecular/genetic findings. The following beacon article may be helpful, depending on how much detail you need:
https://myelomabeacon.org/news/2014/02/19/multiple-myeloma-subtypes-mgus-smoldering-myeloma
As referenced in the article, there are three stages: MGUS, smoldering myeloma and symptomatic myeloma. I'm referring to symptomatic myeloma below.
* immunoglobulin involvement: Ig(G) is most common; Ig(A), Ig(M), Ig(D) and Ig(E) are other possibilities, with IgA being the second most common and Ig(D) and Ig(E) most infrequent
*heavy chain or light chain type.
- If it is a heavy chain subgroup, the M-spike test results are a good way to track disease status.
-A subgroup has light chain only, sometimes called Bence Jones (for the scientists who identified it). The kappa/lambda free light chain test is a good way to track disease status
*secretory or non-secretory. Here's a link to a beacon article discussing the difference: https://myelomabeacon.org/headline/2011/10/21/nonsecretory-multiple-myeloma/
For example, if someone describes an Ig(G) kappa with an m-spike, it can be interpreted as heavy chain, with the involvement in the gamma globulin protein, and the secrete the protein so their disease is apparent from the typical run of myeloma blood tests.
Hope that is helpful to you, and all the best on your myeloma journey
https://myelomabeacon.org/news/2014/02/19/multiple-myeloma-subtypes-mgus-smoldering-myeloma
As referenced in the article, there are three stages: MGUS, smoldering myeloma and symptomatic myeloma. I'm referring to symptomatic myeloma below.
* immunoglobulin involvement: Ig(G) is most common; Ig(A), Ig(M), Ig(D) and Ig(E) are other possibilities, with IgA being the second most common and Ig(D) and Ig(E) most infrequent
*heavy chain or light chain type.
- If it is a heavy chain subgroup, the M-spike test results are a good way to track disease status.
-A subgroup has light chain only, sometimes called Bence Jones (for the scientists who identified it). The kappa/lambda free light chain test is a good way to track disease status
*secretory or non-secretory. Here's a link to a beacon article discussing the difference: https://myelomabeacon.org/headline/2011/10/21/nonsecretory-multiple-myeloma/
For example, if someone describes an Ig(G) kappa with an m-spike, it can be interpreted as heavy chain, with the involvement in the gamma globulin protein, and the secrete the protein so their disease is apparent from the typical run of myeloma blood tests.
Hope that is helpful to you, and all the best on your myeloma journey
-
philatour - Who do you know with myeloma?: spouse
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