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Multiple myeloma vs. reactive plasmacytosis - difference?
I am wondering how elevated plasma cells in the bone marrow from multiple myeloma or MGUS is differentiated from reactive plasmacytosis? Any ideas?
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blair77 - Who do you know with myeloma?: My husband
- When were you/they diagnosed?: April 2013
- Age at diagnosis: 43
Re: Multiple myeloma vs. reactive plasmacytosis - difference
Google is your friend. Fifth entry on a search for "reactive plasmacytosis":
"A Case of Reactive Plasmacytosis Mimicking Multiple Myeloma in A Patient with Primary Sjögren's Syndrome"
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782213/
In the Discussion section of the paper,
"Although clinical features mimicked multiple myeloma, the biopsies of [lymph nodes] and [bone marrow] revealed benign, polyclonal plasma cell infiltration, compatible with reactive plasmacytosis."
Myeloma patients don't just have elevated levels of standard, run-of-the-mill plasma cells in their bone marrow. They have elevated levels of MONOCLONAL (myeloma) plasma cells in their bone marrow.
Plasmacytosis is just a general term for having more than the normal amount of plasma cells in different parts of your body. Multiple myeloma causes plasmacytosis, but its a specific form of plasmacytosis where the excess plasma cells are monoclonal. That's what makes it different from other, non-malignant conditions that can cause plasmacytosis.
"A Case of Reactive Plasmacytosis Mimicking Multiple Myeloma in A Patient with Primary Sjögren's Syndrome"
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782213/
In the Discussion section of the paper,
"Although clinical features mimicked multiple myeloma, the biopsies of [lymph nodes] and [bone marrow] revealed benign, polyclonal plasma cell infiltration, compatible with reactive plasmacytosis."
Myeloma patients don't just have elevated levels of standard, run-of-the-mill plasma cells in their bone marrow. They have elevated levels of MONOCLONAL (myeloma) plasma cells in their bone marrow.
Plasmacytosis is just a general term for having more than the normal amount of plasma cells in different parts of your body. Multiple myeloma causes plasmacytosis, but its a specific form of plasmacytosis where the excess plasma cells are monoclonal. That's what makes it different from other, non-malignant conditions that can cause plasmacytosis.
Re: Multiple myeloma vs. reactive plasmacytosis - difference
Hello, I am an active 48 year-old woman who feels good 50-75% of the time (pretty good right?). I have 4 kids with the youngest 11, and a grandbaby on the way any minute.
I had a cervical polyp removed with final pathology demonstrating chronic reactive plasmacytosis. I have had no blood or urine tests ordered, but the gynecological oncologist my doctor was consulting with suggested a PET scan that came back clear with no abnormal foci (good news) I will have a hysterectomy since my pap came back abnormal (for the first time ever). HPV negative.
I have an appointment with a hematology oncologist May 15th. Based on my research, I need to wait and see what blood, urine, and bone marrow tests come back with.
The only other information I can offer is that I had elevated liver enzymes (ALT, AST, SGGOT, all high) for 10 years until right before I conceived my 11 year-old. Doctors have wondered if I was having an autoimmune response since all tests came back normal except for an ANA that was 1:80 with a speckled pattern.
Questions: has anyone else heard of this? The article the doctor gave me has the heading, "Primary Plasmacytoma Arising in an Endocervical Polyp with Detection of Neoplastic Cells on Pap" ([url=https://doi.org/10.1043/0003-9985(2003)127%3Ce28:PPAIAE%3E2.0.CO;2]full text of article[/url]) and lists only 5 known cases one of which did have multiple myeloma, but the article is from 2003 and has only a 3 year follow-up.
In short, I feel like there is an elephant in the room that everyone (husband / family) is trying to ignore but it is sitting on my lap. Am I worrying too much? Am I blowing this out of proportion? It's great to look on the bright side, but I am worried. (Whew, ok, I just said that.)
Any information good or not is very much appreciated.
With much appreciation,
Lisa
(Get the elephant out of the room!)
I had a cervical polyp removed with final pathology demonstrating chronic reactive plasmacytosis. I have had no blood or urine tests ordered, but the gynecological oncologist my doctor was consulting with suggested a PET scan that came back clear with no abnormal foci (good news) I will have a hysterectomy since my pap came back abnormal (for the first time ever). HPV negative.
I have an appointment with a hematology oncologist May 15th. Based on my research, I need to wait and see what blood, urine, and bone marrow tests come back with.
The only other information I can offer is that I had elevated liver enzymes (ALT, AST, SGGOT, all high) for 10 years until right before I conceived my 11 year-old. Doctors have wondered if I was having an autoimmune response since all tests came back normal except for an ANA that was 1:80 with a speckled pattern.
Questions: has anyone else heard of this? The article the doctor gave me has the heading, "Primary Plasmacytoma Arising in an Endocervical Polyp with Detection of Neoplastic Cells on Pap" ([url=https://doi.org/10.1043/0003-9985(2003)127%3Ce28:PPAIAE%3E2.0.CO;2]full text of article[/url]) and lists only 5 known cases one of which did have multiple myeloma, but the article is from 2003 and has only a 3 year follow-up.
In short, I feel like there is an elephant in the room that everyone (husband / family) is trying to ignore but it is sitting on my lap. Am I worrying too much? Am I blowing this out of proportion? It's great to look on the bright side, but I am worried. (Whew, ok, I just said that.)
Any information good or not is very much appreciated.
With much appreciation,
Lisa
(Get the elephant out of the room!)
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